Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Kim De Keersmaecker"'
Autor:
Anaís Sánchez-Castillo, Kim G. Savelkouls, Alessandra Baldini, Judith Hounjet, Pierre Sonveaux, Paulien Verstraete, Kim De Keersmaecker, Barbara Dewaele, Benny Björkblom, Beatrice Melin, Wendy Y. Wu, Rickard L. Sjöberg, Kasper M. A. Rouschop, Martijn P. G. Broen, Marc Vooijs, Kim R. Kampen
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-18 (2024)
Abstract The serine/glycine (ser/gly) synthesis pathway branches from glycolysis and is hyperactivated in approximately 30% of cancers. In ~13% of glioblastoma cases, we observed frequent amplifications and rare mutations in the gene encoding the enz
Externí odkaz:
https://doaj.org/article/d61b57eb4ce140da832cf94a49f0efd8
Autor:
Benno Verbelen, Tiziana Girardi, Sergey O. Sulima, Stijn Vereecke, Paulien Verstraete, Jelle Verbeeck, Jonathan Royaert, Sonia Cinque, Lorenzo Montanaro, Marianna Penzo, Maya Imbrechts, Nick Geukens, Thomas Geuens, Koen Dierckx, Daniele Pepe, Kim Kampen, Kim De Keersmaecker
Publikováno v:
Engineering in Life Sciences, Vol 22, Iss 2, Pp 100-114 (2022)
Abstract Mammalian cells are commonly used to produce recombinant protein therapeutics, but suffer from a high cost per mg of protein produced. There is therefore great interest in improving protein yields to reduce production cost. We present an ent
Externí odkaz:
https://doaj.org/article/73b319b15a6a48d3af486db291b94fc3
Autor:
Inge Govaerts, Cristina Prieto, Charlien Vandersmissen, Olga Gielen, Kris Jacobs, Sarah Provost, David Nittner, Johan Maertens, Nancy Boeckx, Kim De Keersmaecker, Heidi Segers, Jan Cools
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Background T cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype that comprises 10–15% of childhood and 20–25% of adult ALL cases. Over 70% of T-ALL patients harbor activating mutations in the NOTCH1 signaling pathway and ar
Externí odkaz:
https://doaj.org/article/bb40113fbbf041209361b8411e7b5c92
Autor:
Sarah Meyers, Llucia Alberti-Servera, Olga Gielen, Margot Erard, Toon Swings, Jolien De Bie, Lucienne Michaux, Barbara Dewaele, Nancy Boeckx, Anne Uyttebroeck, Kim De Keersmaecker, Johan Maertens, Heidi Segers, Jan Cools, Sofie Demeyer
Publikováno v:
HemaSphere, Vol 6, Iss 4, p e700 (2022)
Acute lymphoblastic leukemia (ALL) is characterized by the presence of chromosomal changes, including numerical changes, translocations, and deletions, which are often associated with additional single-nucleotide mutations. In this study, we used sin
Externí odkaz:
https://doaj.org/article/e780cd405cf54cd9a5f9fb1d197b4b0f
Autor:
Kim R. Kampen, Laura Fancello, Tiziana Girardi, Gianmarco Rinaldi, Mélanie Planque, Sergey O. Sulima, Fabricio Loayza-Puch, Benno Verbelen, Stijn Vereecke, Jelle Verbeeck, Joyce Op de Beeck, Jonathan Royaert, Pieter Vermeersch, David Cassiman, Jan Cools, Reuven Agami, Mark Fiers, Sarah-Maria Fendt, Kim De Keersmaecker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The ribosomal protein RPL10 is frequently mutated in T-cell acute lymphoblastic leukemia (T-ALL). Here, the authors show that it promotes proliferation of T-ALL cells by upregulating the serine biosynthesis enzyme phosphoserine phosphatase which in t
Externí odkaz:
https://doaj.org/article/556b5b4b144641dfbb1f4cc05deaa24e
Autor:
Delphine Verbeke, Olga Gielen, Kris Jacobs, Nancy Boeckx, Kim De Keersmaecker, Johan Maertens, Anne Uyttebroeck, Heidi Segers, Jan Cools
Publikováno v:
HemaSphere, Vol 3, Iss 6, p e310 (2019)
Externí odkaz:
https://doaj.org/article/ac615e4f316e4ff88f91e9c5df9bf080
Autor:
Sergey O. Sulima, Kim De Keersmaecker
Publikováno v:
HemaSphere, Vol 2, Iss 5, p e95 (2018)
Externí odkaz:
https://doaj.org/article/edb5488fda4c41598f0cd5f568d89c39
Publikováno v:
HemaSphere, Vol 2, Iss 2 (2018)
Externí odkaz:
https://doaj.org/article/9ce7a85f0f9940f7976cb61ce754ffb2
Autor:
Isabel J.F. Hofman, Stephanie Patchett, Mark van Duin, Ellen Geerdens, Jelle Verbeeck, Lucienne Michaux, Michel Delforge, Pieter Sonneveld, Arlen W. Johnson, Kim De Keersmaecker
Publikováno v:
Haematologica, Vol 102, Iss 8 (2017)
Externí odkaz:
https://doaj.org/article/bd894a694cfb40e0bb633e90661d2f03
Publikováno v:
Cells, Vol 8, Iss 3, p 229 (2019)
Ribosomopathies are congenital diseases with defects in ribosome assembly and are characterized by elevated cancer risks. Additionally, somatic mutations in ribosomal proteins have recently been linked to a variety of cancers. Despite a clear correla
Externí odkaz:
https://doaj.org/article/0e0e3f53f73242c9a869a103191d423a