Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Kim Chew Lim"'
Autor:
Bingrui Wang, Chenchen Wang, Yang Wan, Jie Gao, Yige Ma, Yingnan Zhang, Jingyuan Tong, Yingchi Zhang, Jinhua Liu, Lixian Chang, Changlu Xu, Biao Shen, Yumei Chen, Erlie Jiang, Ryo Kurita, Yukio Nakamura, Kim-Chew Lim, James Douglas Engel, Jiaxi Zhou, Tao Cheng, Xiaofan Zhu, Ping Zhu, Lihong Shi
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-19 (2022)
Abstract Ribosomal protein dysfunction causes diverse human diseases, including Diamond–Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the mechanisms underlying ribosomopathies, which are characterized by tissue-
Externí odkaz:
https://doaj.org/article/9b5ff8adcf4941ae8efd9d63a2f23084
Autor:
Sharon A. Singh, Yu Wang, Lei Yu, Takashi Moriguchi, Chia Jui Ku, Julien Pedron, Masayuki Yamamoto, Michael G. Rosenfeld, John H. Bushweller, Greggory Myers, Natee Jearawiriyapaisarn, James Douglas Engel, Rami Khoriaty, Andrew White, Kim-Chew Lim, Emily Schneider
Publikováno v:
Blood. 138:1691-1704
Histone H3 lysine 4 methylation (H3K4Me) is most often associated with chromatin activation, and removing H3K4 methyl groups has been shown to be coincident with gene repression. H3K4Me demethylase KDM1a/LSD1 is a therapeutic target for multiple dise
Autor:
Lei Yu, Greggory Myers, Emily Schneider, Yu Wang, Raven Mathews, Kim Chew Lim, David Siemieniak, Vi Tang, David Ginsburg, Ginette Balbin-Cuesta, Sharon A. Singh, Pongpon Phuwakanjana, Natee Jearawiriyapaisarn, Rami Khoriaty, James Douglas Engel
Publikováno v:
Blood advances. 6(11)
Human γ-globin is predominantly expressed in fetal liver erythroid cells during gestation from 2 nearly identical genes, HBG1 and HBG2, that are both perinatally silenced. Reactivation of these fetal genes in adult red blood cells can ameliorate man
Autor:
Timothy C. Cox, Jacob Dahlka, Makoto Abe, Anthony B. Firulli, Kim-Chew Lim, James Douglas Engel, Stanley M. Kanai, David E. Clouthier
Publikováno v:
Development
Neural crest cells (NCCs) within the mandibular and maxillary prominences of the first pharyngeal arch are initially competent to respond to signals from either region. However, mechanisms that are only partially understood establish developmental ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb3ffff1901854226962ff01ac6281d
https://europepmc.org/articles/PMC8451945/
https://europepmc.org/articles/PMC8451945/
Autor:
Lihong Shi, M C Sierant, Katherine Gurdziel, Fan Zhu, Shuaiying Cui, Katarzyna E Kolodziej, John Strouboulis, Yuanfang Guan, Osamu Tanabe, Kim-Chew Lim, James Douglas Engel
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004339 (2014)
We previously reported that TR2 and TR4 orphan nuclear receptors bind to direct repeat (DR) elements in the ε- and γ-globin promoters, and act as molecular anchors for the recruitment of epigenetic corepressors of the multifaceted DRED complex, the
Externí odkaz:
https://doaj.org/article/42a957fb4a224e1281ea2132e889ffd3
Autor:
Emily Schneider, Andrew White, Yv Wang, Takashi Moriguchi, Kim-Chew Lim, James Douglas Engel, John H. Bushweller, Chia Jui Ku, Julien Pedron, Michael G. Rosenfeld, Natee Jearawiriyapaisarn, Sharon A. Singh, Lei Yu, Greggory Myers, Masayuki Yamamoto, Rami Khoriaty
Histone H3 lysine 4 methylation (H3K4Me) is proximally associated with chromatin activation, and therefore removing H3K4 methyl groups is normally coincident with gene repression. H3K4Me demethylase KDM1a/LSD1 is a potential therapeutic target for mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceb36d58223d2124967452c4d6031439
https://doi.org/10.1101/2021.01.13.426552
https://doi.org/10.1101/2021.01.13.426552
Autor:
Md Riaj, Mahamud, Xin, Geng, Yen-Chun, Ho, Boksik, Cha, Yuenhee, Kim, Jing, Ma, Lijuan, Chen, Greggory, Myers, Sally, Camper, Debbie, Mustacich, Marlys, Witte, Dongwon, Choi, Young-Kwon, Hong, Hong, Chen, Gaurav, Varshney, James Douglas, Engel, Shusheng, Wang, Tae-Hoon, Kim, Kim-Chew, Lim, R Sathish, Srinivasan
Publikováno v:
Development (Cambridge, England)
Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves and lymphovenous valves, and for the patterning of lymphatic vessels. Here, we report that GATA2 is not necessary for valvular en
Autor:
Marlys H. Witte, R. Sathish Srinivasan, Sally A. Camper, Tae Hoon Kim, Md. Riaj Mahamud, Shusheng Wang, Hong Chen, Boksik Cha, Yen-Chun Ho, Yuenhee Kim, Dongwon Choi, Debbie Mustacich, Xin Geng, James Douglas Engel, Greggory Myers, Gaurav K. Varshney, Lijuan Chen, Young-Kwon Hong, Jing Ma, Kim-Chew Lim
Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves (LVs) and lymphovenous valves (LVVs), and for the patterning of lymphatic vessels. Here, we report that GATA2 is not necessary fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be93c7d76cca0db13479aaeb8260b62
https://doi.org/10.1101/660068
https://doi.org/10.1101/660068
Autor:
Shusheng Wang, Xin Geng, Yen Chun Ho, Debbie Mustacich, Young-Kwon Hong, Marlys H. Witte, Gaurav K. Varshney, Tae Hoon Kim, James Douglas Engel, Greggory Myers, Kim Chew Lim, Yuenhee Kim, Jing Ma, Riaj Mahamud, Sally A. Camper, Lijuan Chen, R. Sathish Srinivasan, Boksik Cha, Hong Chen, Dongwon Choi
Publikováno v:
Development.
Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves (LVs) and lymphovenous valves (LVVs), and for the patterning of lymphatic vessels. Here, we report that GATA2 is not necessary fo
Autor:
Lei Yu, Tomonori Hosoya, James Douglas Engel, Greggory Myers, Natee Jearawiriyapaisarn, Yukio Nakamura, Kim-Chew Lim, Mary P. Lee, Jean François Rual, Qingqing Wu, Ryo Kurita, Anne B. Vojtek
Human globin gene production transcriptionally “switches” from fetal to adult synthesis shortly after birth and is controlled by macromolecular complexes that enhance or suppress transcription by cis elements scattered throughout the locus. The D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce8f435d6d784d2501a7084dcc093ae
https://europepmc.org/articles/PMC6295165/
https://europepmc.org/articles/PMC6295165/