Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases.

Autor: Gealageas R; Faculty of Pharmaceutical Sciences , The University of British Columbia , 2405 Wesbrook Mall , Vancouver , British Columbia V6T 1Z3 , Canada., Devineau A; Faculty of Pharmaceutical Sciences , The University of British Columbia , 2405 Wesbrook Mall , Vancouver , British Columbia V6T 1Z3 , Canada., So PPL; Centre for Drug Research and Development , 2405 Wesbrook Mall , Vancouver , British Columbia V6T 1Z3 , Canada., Kim CMJ; Centre for Drug Research and Development , 2405 Wesbrook Mall , Vancouver , British Columbia V6T 1Z3 , Canada., Surendradoss J; Centre for Drug Research and Development , 2405 Wesbrook Mall , Vancouver , British Columbia V6T 1Z3 , Canada., Buchwalder C; Faculty of Pharmaceutical Sciences , The University of British Columbia , 2405 Wesbrook Mall , Vancouver , British Columbia V6T 1Z3 , Canada., Heller M; Centre for Drug Research and Development , 2405 Wesbrook Mall , Vancouver , British Columbia V6T 1Z3 , Canada., Goebeler V; Faculty of Dentistry , The University of British Columbia , 2199 Wesbrook Mall , Vancouver , British Columbia V6T 1Z3 , Canada., Dullaghan EM; Centre for Drug Research and Development , 2405 Wesbrook Mall , Vancouver , British Columbia V6T 1Z3 , Canada., Grierson DS; Faculty of Pharmaceutical Sciences , The University of British Columbia , 2405 Wesbrook Mall , Vancouver , British Columbia V6T 1Z3 , Canada., Putnins EE; Faculty of Dentistry , The University of British Columbia , 2199 Wesbrook Mall , Vancouver , British Columbia V6T 1Z3 , Canada.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Aug 23; Vol. 61 (16), pp. 7043-7064. Date of Electronic Publication: 2018 Aug 01.