Fc gamma receptor IIb on GM-CSF macrophages controls immune complex mediated inhibition of inflammatory signals.

Autor: Kim C M Santegoets, Mark H Wenink, Wim B van den Berg, Timothy R D J Radstake

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e110966 (2014)

In rheumatoid arthritis (RA) macrophages play a major role in amplifying synovial inflammation. Important activating signals are those induced by Toll-like receptor (TLR) ligands and by activated T cells. The balance between activating and inhibitory

Externí odkaz: https://doaj.org/article/97205cfaa86f48e29bd01545fc30a961

Glioma-Associated Sialoglycans Drive the Immune Suppressive Phenotype and Function of Myeloid Cells

Autor: Lenneke A. M. Cornelissen, Kim C. M. Santegoets, Esther D. Kers-Rebel, Sandra A. J. F. H. Bossmann, Mark Ter Laan, Daniel Granado, Gosse J. Adema

Publikováno v: Pharmaceutics, Vol 16, Iss 7, p 953 (2024)

The tumor microenvironment of glioblastoma IDH-wildtype is highly immune suppressive and is characterized by a strong component of myeloid-derived suppressor cells (MDSCs). To interfere with the immune suppressive functions of MDSCs, a comprehensive

Externí odkaz: https://doaj.org/article/97a25e7e2fbb4e2a8bccf18503ec2409

Interactions among myeloid regulatory cells in cancer

Autor: Jo A. Van Ginderachter, Slavko Mojsilović, Yu Si, Gosse J. Adema, Sven Brandau, Jadwiga Jablonska, Juan F. Santibanez, Jarosław Baran, Maria Velegraki, Isabela Sieminska, Xiaoying Hu, Karine Serre, Helen A. Papadaki, Yago Pico de Coaña, Viktor Umansky, Kim C. M. Santegoets, Zvi G. Fridlender

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cancer Immunology Immunotherapy, 68, 645-660
Cancer Immunology Immunotherapy
Cancer Immunology Immunotherapy, 68, 4, pp. 645-660

© Springer-Verlag GmbH Germany, part of Springer Nature 2018
Mounting evidence has accumulated on the critical role of the different myeloid cells in the regulation of the cancerous process, and in particular in the modulation of the immune rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea75bec75fffe7c7ca9ab0046953168
https://hdl.handle.net/2066/202815

Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation

Autor: Ana Godinho-Santos, Monika Kapinska-Mrowiecka, Magdalena Król, Michael Dixon, Karin Loré, Luca Cassetta, Derya Karakoc, Verena Müller, Bartłomiej Taciak, Elisabeth Ersvær, Ida Marie Rundgren, Jochen Utikal, Jeffrey W. Pollard, Kirsten Bruderek, Esther D. Kers-Rebel, Thalia Garcia-Tellez, Gunes Esendagli, Utku Horzum, Mark ter Laan, Benedikt Höing, Kerim Bora Yilmaz, Kim C. M. Santegoets, Stephan Lang, Mirjana Gotic, Lubomir Bodnar, Michaela Müller-Trutwin, Christine Bourgeois, Olympia E. Anastasiou, Oktawia Osiecka, Suncica Bjelica, Joanna Skrzeczynska-Moncznik, Viktor Umansky, Sven Brandau, Juan F. Santibanez, Robert Badura, Ang Lin, Joanna Cichy, Gennadiy Zelinskyy, Emilia Górka, Astrid Olsnes Kittang, Ulf Dittmer, Xiaoying Hu, Ana E. Sousa, Gosse J. Adema

Publikováno v: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for ImmunoTherapy of Cancer (JITC)
e001223
Journal for ImmunoTherapy of Cancer
Journal for Immunotherapy of Cancer, 8, 2
8:e001223
Cassetta, L, Bruderek, K, Skrzeczynska-Moncznik, J, Osiecka, O, Hu, X, Rundgren, I M, Lin, A, Santegoets, K, Horzum, U, Godinho-Santos, A, Zelinskyy, G, Garcia-Tellez, T, Bjelica, S, Taciak, B, Olsnes Kittang, A, Hoing, B, Lang, S, Dixon, M, Muller, V, Utikal, J, Karakoc, D, Bora Yilmaz, K, Gorka, E, Bodnar, L, Anastasiou, O, Bourgeois, C, Badura, R, Kapinska-Mrowiecka, M, Gotic, M, ter Laan, M, Kers-Rebel, E, Krol, M, Francisco Santibanez, J, Muller-Trutwin, M, Dittmer, U, Sousa, A E, Esendagli, G, Adema, G, Lore, K, Ersvaer, E, Umansky, V, Pollard, J W, Cichy, J & Brandau, S 2020, ' Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation ', British Medical Journal (BMJ) . https://doi.org/10.1136/jitc-2020-001223
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Journal for Immunotherapy of Cancer, 8

© Author(s) (or their employer(s)) 2020. Re- use permitted under CC BY- NC. No commercial re- use. See rights and permissions. Published by BMJ.
Background: Myeloid-derived suppressor cells (MDSC) are a functional myeloid cell subset that inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5805f0990b08e25cffcec44128d297e
http://rimi.imi.bg.ac.rs/bitstream/id/792/991.pdf

Toll-like receptors in rheumatic diseases: Are we paying a high price for our defense against bugs?

Autor: Kim C. M. Santegoets, W.B. van den Berg, Timothy R D J Radstake, L. van Bon, Mark H. Wenink

Publikováno v: FEBS Letters, 585, 3660-6
FEBS Letters, 585, 23, pp. 3660-6

Item does not contain fulltext In the last decade Toll-like receptor (TLR) research has led to new insights in the pathogenesis of many rheumatic diseases. In autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis and systemic sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1a82a130d3ebc53905a90170bb734b
https://hdl.handle.net/2066/96471