Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kim Bujold"'
Autor:
Shanaz A. Ghandhi, Shad R. Morton, Igor Shuryak, Younghyun Lee, Rajesh K. Soni, Jay R. Perrier, James Bakke, Janet Gahagan, Kim Bujold, Simon Authier, Sally A. Amundson, David J. Brenner, Denise Nishita, Polly Chang, Helen C. Turner
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Background Non-human primates, such as Rhesus macaques, are a powerful model for studies of the cellular and physiological effects of radiation, development of radiation biodosimetry, and for understanding the impact of radiation on human he
Externí odkaz:
https://doaj.org/article/e3eec020d628404887323c5ef5dd4b5f
Autor:
Evan L. Pannkuk, Evagelia C. Laiakis, Michael Girgis, Sarah E. Dowd, Suraj Dhungana, Denise Nishita, Kim Bujold, James Bakke, Janet Gahagen, Simon Authier, Polly Y. Chang, Albert J. Fornace
Publikováno v:
Metabolites, Vol 9, Iss 5, p 98 (2019)
Whole body exposure to ionizing radiation damages tissues leading to physical symptoms which contribute to acute radiation syndrome. Radiation biodosimetry aims to determine characteristic early biomarkers indicative of radiation exposure and is nece
Externí odkaz:
https://doaj.org/article/fd32ddd383cf42d5888349ba52a9e469
Autor:
Shanaz A. Ghandhi, Shad. R. Morton, Igor Shuryak, Younghyun Lee, Rajesh K. Soni, Jay R. Perrier, James Bakke, Janet Gahagan, Kim Bujold, Simon Authier, Sally A. Amundson, David J. Brenner, Denise Nishita, Polly Chang, Helen C. Turner
Background: Non-human primates, such as Rhesus macaques, are a powerful model for studies of the cellular and physiological effects of radiation, development of radiation biodosimetry, and for understanding the impact of radiation on human health. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adf43ece272c42143db9a7db51bf60ae
https://doi.org/10.21203/rs.3.rs-2160155/v1
https://doi.org/10.21203/rs.3.rs-2160155/v1
Autor:
Evagelia C. Laiakis, Meth Jayatilake, Janet Gahagen, James Bakke, Kim Bujold, Albert J. Fornace, Denise Nishita, Polly Y. Chang, Simon Authier
Publikováno v:
Int J Radiat Oncol Biol Phys
PURPOSE: To identify metabolomic biomarkers of acute radiation exposure in saliva that show time-dependent changes. METHODS AND MATERIALS: Non-human primates (NHPs) were exposed to 4 Gy of total body irradiation with γ-rays. Saliva was collected fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6809bb8b1400509b00ca582b3545818e
https://doi.org/10.1016/j.ijrobp.2019.07.017
https://doi.org/10.1016/j.ijrobp.2019.07.017
Autor:
Richard Malcolmson, Andrew P.-Z. Clark, James B Fink, Plamena Entcheva-Dimitrov, Juergen W. Pfeiffer, Dennis Sullivan, Simon Authier, Kim Bujold, Jeffrey S. Tepper
Publikováno v:
International journal of toxicology. 39(5)
Currently, off-label continuous administration of inhaled epoprostenol is used to manage hemodynamics during mitral valve surgery. A toxicology program was developed to support the use of inhaled epoprostenol during mechanical ventilation as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d257de9b3d7c7a73ebba3578c25b239d
https://pubmed.ncbi.nlm.nih.gov/32787636
https://pubmed.ncbi.nlm.nih.gov/32787636
Autor:
Simon Authier, Ghaith Altawallbeh, Laura Smith, Stephen J. Lewis, Kim Bujold, Benjamin Gaston, Ilya Bederman
Publikováno v:
Drug Testing and Analysis. 11:403-410
Context Sudaxine is a novel respiratory stimulant that increases ventilatory drive via NO+ -thiolate signaling and is under development for reversal of opioid-induced respiratory depression and other critical care indications. Objective This study in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cdaa37b92c83fe8c7e2b59539393f7b
https://doi.org/10.1002/dta.2507
https://doi.org/10.1002/dta.2507
Autor:
Suraj Dhungana, Kim Bujold, Polly Y. Chang, Evagelia C. Laiakis, Michael Girgis, Simon Authier, Sarah E. Dowd, James Bakke, Janet Gahagen, Evan L. Pannkuk, Albert J. Fornace, Denise Nishita
Whole body exposure to ionizing radiation (IR) (> 0.7 Gy) damages tissues leading to a range of physical symptoms contributing to acute radiation syndrome (ARS). Radiation biodosimetry aims to determine characteristic early biomarkers indicative of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3cda2395994665e61a6758d7cbca5d7
https://doi.org/10.1101/620526
https://doi.org/10.1101/620526
Autor:
James Bakke, Simon Authier, Polly Y. Chang, Albert J. Fornace, Kirandeep Gill, Khyati Y. Mehta, Kim Bujold, Shreyans K. Jain, Evagelia C. Laiakis, Evan L. Pannkuk, Janet Gahagen, Denise Nishita
Publikováno v:
Journal of proteome research. 18(5)
Rapid assessment of radiation signatures in non-invasive biofluids may aid in assigning proper medical treatments for acute radiation syndrome (ARS) and delegating limited resources after a nuclear disaster. Metabolomic platforms allow for rapid scre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e212ec5cb7cbf5e0b10da2fff8d5c9
https://pubmed.ncbi.nlm.nih.gov/30843397
https://pubmed.ncbi.nlm.nih.gov/30843397
Publikováno v:
Journal of pharmacological and toxicological methods. 99
Introduction For nonclinical drug development, it is optimal if safety pharmacology and toxicology studies are performed in a model that reasonably represents the patient the drug is intended to treat. To simulate prolonged inhalation therapy in vent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234da98a51d6cccec4112375884b4576
https://pubmed.ncbi.nlm.nih.gov/31078712
https://pubmed.ncbi.nlm.nih.gov/31078712
Characterization of a partial-body irradiation model with oral cavity shielding in nonhuman primates
Autor:
Thomas Measey, Hai Huang, Julius Haruna, Mylene Pouliot, Simon Authier, Wieslaw Wierzbicki, Michael V. Accardi, Oreola Donini, Adam Rumage, John Stamatopoulos, Houman Naraghi, Kim Bujold, Alexis Ascah
Publikováno v:
International journal of radiation biology. 96(1)
Purpose: Characterization of a novel partial-body irradiation (PBI) shielding strategy in nonhuman primates (NHP; rhesus macaques), aimed at protecting the oral cavity, with respect to various gast...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f852edf83bd7e8fa81436796f743934a
https://pubmed.ncbi.nlm.nih.gov/29447591
https://pubmed.ncbi.nlm.nih.gov/29447591