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The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex
Publikováno v:
Journal of Cell Science
ESCRT-I is essential for the multivesicular body (MVB) sorting of ubiquitylated cargo such as epidermal growth factor receptor, as well as for several cellular functions, such as cell division and retroviral budding. ESCRT-I has four subunits; TSG101
Autor:
Stuart Pickering-Brown, Johanna Donovan, Janis Bennion, Aurelie Doyotte, Sandra Taylor, Kim Brownhill, Flavia Stefani, Ling Zhang, Philip G. Woodman, Sara Rollinson
Publikováno v:
Current Biology. 21:1245-1250
SummaryEndosomal sorting complexes required for transport (ESCRTs) regulate several events involving membrane invagination, including multivesicular body (MVB) biogenesis, viral budding, and cytokinesis [1]. In each case, upstream ESCRTs combine with
Publikováno v:
Seminars in Cell & Developmental Biology. 20:784-792
The Golgi apparatus is a highly dynamic organelle through which nascent proteins released from the endoplasmic reticulum (ER) are trafficked. Proteins are post-translationally modified within the Golgi and subsequently packaged into carriers for tran
Autor:
Becky Bola, Kim Brownhill, Yen Ching Yang, Marcin J. Woźniak, Vesselina Levakova, Victoria J. Allan
Publikováno v:
Journal of Cell Science. 122:1979-1989
Generating the extended endoplasmic reticulum (ER) network depends on microtubules, which act as tracks for motor-driven ER tubule movement, generate the force to extend ER tubules by means of attachment to growing microtubule plus-ends and provide s