Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kim Bartels"'
Autor:
Melissa A. Graewert, Christoph Wilhelmy, Tijana Bacic, Jens Schumacher, Clement Blanchet, Florian Meier, Roland Drexel, Roland Welz, Bastian Kolb, Kim Bartels, Thomas Nawroth, Thorsten Klein, Dmitri Svergun, Peter Langguth, Heinrich Haas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract We present a generically applicable approach to determine an extensive set of size-dependent critical quality attributes inside nanoparticulate pharmaceutical products. By coupling asymmetrical-flow field-flow fractionation (AF4) measurement
Externí odkaz:
https://doaj.org/article/6cbcb21a01a44fe191b433cb76ef64fd
Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition
Autor:
Vadim Kotov, Maxime Killer, Katharina E.J. Jungnickel, Jian Lei, Giada Finocchio, Josi Steinke, Kim Bartels, Jan Strauss, Florine Dupeux, Anne-Sophie Humm, Irina Cornaciu, José A. Márquez, Els Pardon, Jan Steyaert, Christian Löw
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112831- (2023)
Summary: Proton-dependent oligopeptide transporters (POTs) are promiscuous transporters of the major facilitator superfamily that constitute the main route of entry for a wide range of dietary peptides and orally administrated peptidomimetic drugs. G
Externí odkaz:
https://doaj.org/article/fd27d33b5518420ebb2f497a27ffb4e6
Autor:
Felix Wiggers, Gabriel Rosenblum, Hagen Hofmann, Jakub Jungwirth, Tanya Lasitza-Male, Kim Bartels, Christian Löw
Publikováno v:
Angewandte Chemie (International Ed. in English)
Membrane proteins require lipid bilayers for function. While lipid compositions reach enormous complexities, high‐resolution structures are usually obtained in artificial detergents. To understand whether and how lipids guide membrane protein funct
Publikováno v:
ChemBioChem 22(17), 2657-2671 (2021). doi:10.1002/cbic.202100106
Chembiochem
Chembiochem
ChemBioChem 22(17), 2657 - 2671 (2021). doi:10.1002/cbic.202100106
Uncovering the structure and function of biomolecules is a fundamental goal in structural biology. Membrane-embedded transport proteins are ubiquitous in all kingdoms of life. De
Uncovering the structure and function of biomolecules is a fundamental goal in structural biology. Membrane-embedded transport proteins are ubiquitous in all kingdoms of life. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a9db8e954209079b533698f5047416
https://bib-pubdb1.desy.de/record/473961
https://bib-pubdb1.desy.de/record/473961
Publikováno v:
ChemBioChem. 22:2655-2655
Autor:
Yonca Ural-Blimke, Jan Kosinski, Els Pardon, Esben M. Quistgaard, Jan Strauss, Vasileios Rantos, Ali Flayhan, Jan Steyaert, Kim Bartels, Christian Löw, Rolf Nielsen
Publikováno v:
Journal of the American Chemical Society, 141 (6). pp. 2404-2412.
Ural-Blimke, Y, Flayhan, A, Strauss, J, Rantos, V, Bartels, K, Nielsen, R, Pardon, E, Steyaert, J, Kosinski, J, Quistgaard, E M & Löw, C 2019, ' Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1 ', Journal of the American Chemical Society, vol. 141, no. 6, pp. 2404-2412 . https://doi.org/10.1021/jacs.8b11343
'Journal of the American Chemical Society ', vol: 141, pages: 2404-2412 (2019)
Journal of the American Chemical Society 141(6), 2404-2412 (2019). doi:10.1021/jacs.8b11343
Journal of the American Chemical Society
Ural-Blimke, Y, Flayhan, A, Strauss, J, Rantos, V, Bartels, K, Nielsen, R, Pardon, E, Steyaert, J, Kosinski, J, Quistgaard, E M & Löw, C 2019, ' Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1 ', Journal of the American Chemical Society, vol. 141, no. 6, pp. 2404-2412 . https://doi.org/10.1021/jacs.8b11343
'Journal of the American Chemical Society ', vol: 141, pages: 2404-2412 (2019)
Journal of the American Chemical Society 141(6), 2404-2412 (2019). doi:10.1021/jacs.8b11343
Journal of the American Chemical Society
Members of the solute carrier 15 family (SLC15) transport di- and tripeptides as well as peptidomimetic drugs across the cell membrane. Structures of bacterial homologues have provided valuable information on the binding and transport of their natura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52542ea688ea45c63cd9d3e61f90a815
http://oceanrep.geomar.de/51474/
http://oceanrep.geomar.de/51474/
Autor:
Katharina Veith, Henning Tidow, Kim Bartels, Thomas C. Marlovits, Udaya Kumar Tiruttani Subhramanyam, Christian Günther, Inokentijs Josts, Christian Löw, Maria Garcia-Alai, Jörg Labahn, Vadim Kotov, Isabel Moraes
Publikováno v:
Scientific Reports
Scientific reports 9(1), 10379 (2019). doi:10.1038/s41598-019-46686-8
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific reports 9(1), 10379 (2019). doi:10.1038/s41598-019-46686-8
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Protein stability in detergent or membrane-like environments is the bottleneck for structural studies on integral membrane proteins (IMP). Irrespective of the method to study the structure of an IMP, detergent solubilization from the membrane is usua
Autor:
Jakub Jungwirth, Christian Löw, Felix Wiggers, Hagen Hofmann, Kim Bartels, Gabriel Rosenblum, Tanya Lasitza-Male
Publikováno v:
Angewandte Chemie International Edition. 59:19360-19360
Autor:
Felix Wiggers, Gabriel Rosenblum, Tanya Lasitza-Male, Kim Bartels, Jakub Jungwirth, Christian Löw, Hagen Hofmann
Publikováno v:
Angewandte Chemie. 132:19528-19528
Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition
Autor:
Vadim Kotov, Maxime Killer, Katharina E. J. Jungnickel, Jian Lei, Giada Finocchio, Josi Steinke, Kim Bartels, Jan Strauss, Florine Dupeux, Anne-Sophie Humm, Irina Cornaciu, José A. Márquez, Els Pardon, Jan Steyaert, Christian Löw
Publikováno v:
bioRxiv
SummaryProton-coupled oligopeptide transporters (POTs) are promiscuous transporters of the Major Facilitator Superfamily, that constitute the main route of entry for a wide range of dietary peptides and orally administrated peptidomimetic drugs. Give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35edbd8c2b02cffb9fe5906f251a8c6