Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kim A. Lennox"'
Autor:
Peter Järver, Aleksandra Dondalska, Candice Poux, AnnSofi Sandberg, Joseph Bergenstråhle, Annette E. Sköld, Nathalie Dereuddre-Bosquet, Fréderic Martinon, Sandra Pålsson, Eman Zaghloul, David Brodin, Birgitta Sander, Kim A. Lennox, Mark A. Behlke, Samir EL-Andaloussi, Janne Lehtiö, Joakim Lundeberg, Roger LeGrand, Anna-Lena Spetz
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Abstract Recognition of nucleic acids by endosomal Toll-like receptors (TLR) is essential to combat pathogens, but requires strict control to limit inflammatory responses. The mechanisms governing this tight regulation are unclear. We found that sing
Externí odkaz:
https://doaj.org/article/8ee60f6cd9e941b7b20a1654b77636dc
Publikováno v:
Neurobiology of Disease, Vol 56, Iss , Pp 6-13 (2013)
Spinocerebellar Ataxia Type 1 (SCA1) is an autosomal dominant late onset neurodegenerative disease caused by an expanded polyglutamine tract in ataxin-1. Here, we compared the protective effects of overexpressing ataxin-1-like using recombinant AAVs,
Externí odkaz:
https://doaj.org/article/b4657bcb5aa94fbd867ab152a83c24e3
Autor:
Rafal Goraczniak, Brian A Wall, Mark A Behlke, Kim A Lennox, Eric S Ho, Nikolas H Zaphiros, Christopher Jakubowski, Neil R Patel, Steven Zhao, Carlo Magaway, Stacey A Subbie, Lumeng Jenny Yu, Stephanie LaCava, Kenneth R Reuhl, Suzie Chen, Samuel I Gunderson
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
U1 Adaptor is a recently discovered oligonucleotide-based gene-silencing technology with a unique mechanism of action that targets nuclear pre-mRNA processing. U1 Adaptors have two distinct functional domains, both of which must be present on the sam
Externí odkaz:
https://doaj.org/article/05875fbc03754cd9bb797287478d6134
Autor:
Kim A, Lennox, Mark A, Behlke
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2176
Long noncoding RNAs (lncRNAs) are a recently discovered class of RNA that have diverse intracellular regulatory and structural roles. Because of their wide assortment of functions, lncRNAs can have varied distributions in the nucleus and/or cytoplasm
Autor:
Kim A. Lennox, Genevieve Pepin, Christophe Wong, Solène Pradeloux, Hong Mei Li, Marcel F. Nold, Roxane Valentin, Mark A. Behlke, Sarah Straub, Aurélie J. Garcin, Claudia A. Nold-Petry, Arwaf S. Alharbi, Michael P. Gantier
Publikováno v:
Nucleic Acids Research
Oligonucleotide-based therapeutics have become a reality, and are set to transform management of many diseases. Nevertheless, the modulatory activities of these molecules on immune responses remain incompletely defined. Here, we show that gene target
Autor:
Kim A, Lennox, Mark A, Behlke
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2115
Chemically modified oligonucleotides (ONs) are routinely used in the laboratory to assess gene function, and clinical advances are rapidly progressing as continual efforts are being made to optimize ON efficacy. Over the years, RNA interference (RNAi
Autor:
Kim A. Lennox, Mark A. Behlke
Publikováno v:
Methods in Molecular Biology ISBN: 9781071607701
Long noncoding RNAs (lncRNAs) are a recently discovered class of RNA that have diverse intracellular regulatory and structural roles. Because of their wide assortment of functions, lncRNAs can have varied distributions in the nucleus and/or cytoplasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5924ae28b80c97c94887c7dd5c6ae6b
https://doi.org/10.1007/978-1-0716-0771-8_9
https://doi.org/10.1007/978-1-0716-0771-8_9
Autor:
Mark A. Behlke, Kim A. Lennox
Publikováno v:
RNA Interference and CRISPR Technologies ISBN: 9781071602898
Chemically modified oligonucleotides (ONs) are routinely used in the laboratory to assess gene function, and clinical advances are rapidly progressing as continual efforts are being made to optimize ON efficacy. Over the years, RNA interference (RNAi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7dce9e42a73c11a3bfac7f554c72702
https://doi.org/10.1007/978-1-0716-0290-4_2
https://doi.org/10.1007/978-1-0716-0290-4_2
Publikováno v:
Journal of Rare Diseases Research & Treatment. 1:66-70
Autor:
Yuzhuo Wang, Yuwei Wang, Arun Azad, Hui Xue, Akira Watahiki, Abhijit Parolia, Cheryl D. Helgason, Serenella Eppenberger-Castori, Kim A. Lennox, Francesco Crea, Larissa Pikor, Luca Quagliata, Hardev Pandha, Agnieszka Michael, Kim N. Chi, Martin E. Gleave, R. Morant, Wan L. Lam, Paolo Frumento, Hui Hsuan Rebecca Liu
Publikováno v:
Molecular Oncology
Metastasis is the primary cause of death in prostate cancer (PCa) patients. Small nucleolar RNAs (snoRNAs) have long been considered “housekeeping” genes with no relevance for cancer biology. Emerging evidence has challenged this assumption, sugg