Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kim A. Lagerborg"'
Autor:
Emily Golden, Rabab Rashwan, Eleanor A. Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyàs, Magdalena Ratajska, Iwona Kardaś, Piotr Kozlowski, Elizabeth K. M. Johnstone, Heng B. See, Ciara Duffy, Jeremy Parry, Kim A. Lagerborg, Piotr Czapiewski, Javier A. Menendez, Adam Gorczyński, Bartosz Wasag, Kevin D. G. Pfleger, Christina Curtis, Bum-Kyu Lee, Jonghwan Kim, Joseph Cursons, Nathan J. Pavlos, Wojciech Biernat, Mohit Jain, Andrew J. Woo, Andrew Redfern, Pilar Blancafort
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Adipogenesis associated Mth938 Domain Containing gene (AAMDC) is frequently amplified in the IntClus2 subgroup of ER + breast cancer. Here, the authors show that AAMDC drives tumourigenesis through activating PI3K-AKT-mTOR pathway for metabolic repro
Externí odkaz:
https://doaj.org/article/7a78efc95f94434186efe33c5a90c19a
Autor:
Mir Henglin, Brian L. Claggett, Joseph Antonelli, Mona Alotaibi, Gino Alberto Magalang, Jeramie D. Watrous, Kim A. Lagerborg, Gavin Ovsak, Gabriel Musso, Olga V. Demler, Ramachandran S. Vasan, Martin G. Larson, Mohit Jain, Susan Cheng
Publikováno v:
Metabolites, Vol 12, Iss 6, p 519 (2022)
Emerging technologies now allow for mass spectrometry-based profiling of thousands of small molecule metabolites (‘metabolomics’) in an increasing number of biosamples. While offering great promise for insight into the pathogenesis of human disea
Externí odkaz:
https://doaj.org/article/dfb1475dcbb94aa896318690f8f5114a
Autor:
Joonatan Palmu, Jeramie D. Watrous, Kysha Mercader, Aki S. Havulinna, Kim A. Lagerborg, Aaro Salosensaari, Mike Inouye, Martin G. Larson, Jian Rong, Ramachandran S. Vasan, Leo Lahti, Allen Andres, Susan Cheng, Pekka Jousilahti, Veikko Salomaa, Mohit Jain, Teemu J. Niiranen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 19 (2020)
Background Epidemiological and animal studies have associated systemic inflammation with blood pressure (BP). However, the mechanistic factors linking inflammation and BP remain unknown. Fatty acid–derived eicosanoids serve as mediators of inflamma
Externí odkaz:
https://doaj.org/article/0b22cd2a50454757b316deab2c11a096
Autor:
Irena Roci, Jeramie D. Watrous, Kim A. Lagerborg, Lorenzo Lafranchi, Arne Lindqvist, Mohit Jain, Roland Nilsson
Publikováno v:
Cell Reports, Vol 26, Iss 7, Pp 1691-1700.e5 (2019)
Summary: Alterations in cell-cycle regulation and cellular metabolism are associated with cancer transformation, and enzymes active in the committed cell-cycle phase may represent vulnerabilities of cancer cells. Here, we map metabolic events in the
Externí odkaz:
https://doaj.org/article/7b10a39363e0477dbac11342bc364153
Autor:
Olga V. Demler, Yanyan Liu, Heike Luttmann-Gibson, Jeramie D. Watrous, Kim A. Lagerborg, Hesam Dashti, Franco Giulianini, Mallory Heath, Carlos A. Camargo, William S. Harris, Jay G. Wohlgemuth, Allen M. Andres, Saumya Tivari, Tao Long, Mahan Najhawan, Khoi Dao, James G. Prentice, Julia A. Larsen, Olivia I. Okereke, Karen H. Costenbader, Julie E. Buring, JoAnn E. Manson, Susan Cheng, Mohit Jain, Samia Mora
Publikováno v:
Metabolites, Vol 10, Iss 11, p 431 (2020)
Omega-3 (n-3) treatment may lower cardiovascular risk, yet its effects on the circulating lipidome and relation to cardiovascular risk biomarkers are unclear. We hypothesized that n-3 treatment is associated with favorable changes in downstream fatty
Externí odkaz:
https://doaj.org/article/83c39b76471a4147acd90b85adca4e35
Autor:
Mir Henglin, Teemu Niiranen, Jeramie D. Watrous, Kim A. Lagerborg, Joseph Antonelli, Brian L. Claggett, Emmanuella J. Demosthenes, Beatrice von Jeinsen, Olga Demler, Ramachandran S. Vasan, Martin G. Larson, Mohit Jain, Susan Cheng
Publikováno v:
Metabolites, Vol 9, Iss 7, p 128 (2019)
To assist with management and interpretation of human metabolomics data, which are rapidly increasing in quantity and complexity, we need better visualization tools. Using a dataset of several hundred metabolite measures profiled in a cohort of ~1500
Externí odkaz:
https://doaj.org/article/29c822ef07064a87860cbc3d268505e1
Autor:
Joseph Antonelli, Brian L. Claggett, Mir Henglin, Andy Kim, Gavin Ovsak, Nicole Kim, Katherine Deng, Kevin Rao, Octavia Tyagi, Jeramie D. Watrous, Kim A. Lagerborg, Pavel V. Hushcha, Olga V. Demler, Samia Mora, Teemu J. Niiranen, Alexandre C. Pereira, Mohit Jain, Susan Cheng
Publikováno v:
Metabolites, Vol 9, Iss 7, p 143 (2019)
High-throughput metabolomics investigations, when conducted in large human cohorts, represent a potentially powerful tool for elucidating the biochemical diversity underlying human health and disease. Large-scale metabolomics data sources, generated
Externí odkaz:
https://doaj.org/article/81da88040d454ee49c2abefc439e5f6c
Autor:
Kim A. Lagerborg, Erica Normandin, Matthew R. Bauer, Gordon Adams, Katherine Figueroa, Christine Loreth, Adrianne Gladden-Young, Bennett M. Shaw, Leah R. Pearlman, Daniel Berenzy, Hannah B. Dewey, Susan Kales, Sabrina T. Dobbins, Erica S. Shenoy, David Hooper, Virginia M. Pierce, Kimon C. Zachary, Daniel J. Park, Bronwyn L. MacInnis, Ryan Tewhey, Jacob E. Lemieux, Pardis C. Sabeti, Steven K. Reilly, Katherine J. Siddle
Publikováno v:
Nat Microbiol
The global spread and continued evolution of SARS-CoV-2 has driven an unprecedented surge in viral genomic surveillance. Amplicon-based sequencing methods provide a sensitive, low-cost and rapid approach but suffer a high potential for contamination,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b53c64fca1bda6ff0f2d9e2e3c672d6
https://doi.org/10.1038/s41564-021-01019-2
https://doi.org/10.1038/s41564-021-01019-2
Autor:
Karolina Tuomisto, Joonatan Palmu, Tao Long, Jeramie D Watrous, Kysha Mercader, Kim A Lagerborg, Allen Andres, Marko Salmi, Sirpa Jalkanen, Ramachandran S Vasan, Michael Inouye, Aki S Havulinna, Jaakko Tuomilehto, Pekka Jousilahti, Teemu J Niiranen, Susan Cheng, Mohit Jain, Veikko Salomaa
IntroductionPeptide markers of inflammation have been associated with the development of type 2 diabetes. The role of upstream, lipid-derived mediators of inflammation such as eicosanoids, remains less clear. The aim of this study was to examine whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f8c8791ea8dd08d73d990960f8ebf1
https://www.repository.cam.ac.uk/handle/1810/336821
https://www.repository.cam.ac.uk/handle/1810/336821
Autor:
Alexandra C. Stanton, Kim A. Lagerborg, Liana Tellez, Allison Krunnfusz, Emily M. King, Simon Ye, Isaac H. Solomon, Mohammadsharif Tabebordbar, Pardis C. Sabeti
Publikováno v:
Med. 4:31-50.e8
Adeno-associated virus (AAV) vectors are a promising vehicle for noninvasive gene delivery to the central nervous system via intravenous infusion. However, naturally occurring serotypes have a limited ability to transduce the brain, and translating e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1234f98abcc2c823c01000124f087b8
https://doi.org/10.1016/j.medj.2022.11.002
https://doi.org/10.1016/j.medj.2022.11.002