Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kim A Hatch"'
Autor:
Rose E Jeeves, Alice A N Marriott, Steven T Pullan, Kim A Hatch, Jon C Allnutt, Irene Freire-Martin, Charlotte L Hendon-Dunn, Robert Watson, Adam A Witney, Richard H Tyler, Catherine Arnold, Philip D Marsh, Timothy D McHugh, Joanna Bacon
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138253 (2015)
An important aim for improving TB treatment is to shorten the period of antibiotic therapy without increasing relapse rates or encouraging the development of antibiotic-resistant strains. In any M. tuberculosis population there is a proportion of bac
Externí odkaz:
https://doaj.org/article/b77774f4b89f45aa86fd10187fd3db40
Autor:
Joanna Bacon, Luke J Alderwick, Jon A Allnutt, Evelina Gabasova, Robert Watson, Kim A Hatch, Simon O Clark, Rose E Jeeves, Alice Marriott, Emma Rayner, Howard Tolley, Geoff Pearson, Graham Hall, Gurdyal S Besra, Lorenz Wernisch, Ann Williams, Philip D Marsh
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87329 (2014)
A key feature of Mycobacterium tuberculosis is its ability to become dormant in the host. Little is known of the mechanisms by which these bacilli are able to persist in this state. Therefore, the focus of this study was to emulate environmental cond
Externí odkaz:
https://doaj.org/article/c11cea27e6004c5da7415a8a6a12a1b4
Autor:
Jon C. Allnutt, Joanna Bacon, Charlotte L. Hendon-Dunn, Alice A. N. Marriott, Henry Pertinez, Kim A. Hatch, Geraint Davies
Publikováno v:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Modulation of growth rate in Mycobacterium tuberculosis is key to its survival in the host; particularly with regard to its adaptation during chronic infection when the growth rate is very slow. The resulting physiological changes will influence the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036e42506787d01972aaf6a6a76c53ac
https://doi.org/10.1128/aac.00570-19
https://doi.org/10.1128/aac.00570-19
Autor:
Stephen Thomas, Graham Bottley, Kim A. Hatch, Philip Marsh, Joanna Bacon, Robert J. Watson, Stephen Taylor, Jonathan Charles Allnutt, Kathryn Doris, Charlotte L. Hendon-Dunn, Alice A. N. Marriott
Publikováno v:
Antimicrobial Agents and Chemotherapy
Current methods for assessing the drug susceptibility of Mycobacterium tuberculosis are lengthy and do not capture information about viable organisms that are not immediately culturable under standard laboratory conditions as a result of antibiotic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812b54544247faf9a5eccf7c480e52c4
https://doi.org/10.1128/aac.02712-15
https://doi.org/10.1128/aac.02712-15
Autor:
Kim S. Hatch
Publikováno v:
Geological Society of America Abstracts with Programs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01b756e249bb483dc1e3266e5004507f
https://doi.org/10.1130/abs/2017am-300478
https://doi.org/10.1130/abs/2017am-300478
Autor:
Rose E. Jeeves, Philip Marsh, Jon C. Allnutt, Kim A. Hatch, Rebecca Devine, Steven T. Pullan, Joanna Bacon, Charlotte L. Hendon-Dunn
Publikováno v:
BMC Infectious Diseases
Background Pyrazinamide (PZA) plays an essential part in the shortened six-month tuberculosis (TB) treatment course due to its activity against slow-growing and non-replicating organisms. We tested whether PZA preferentially targets slow growing cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f863a6833f0903a4d579bc8b16550e98
https://pubmed.ncbi.nlm.nih.gov/27184366
https://pubmed.ncbi.nlm.nih.gov/27184366
Autor:
Gurdyal S. Besra, Sharon L. Kendall, Yi Zhang, Kim A. Hatch, Philip Marsh, Neil G. Stoker, Lorenz Wernisch, Jessica M. Gomes, Joanna Bacon, Philip D. Butcher, Lynn G. Dover
Publikováno v:
Microbiology. 153:1435-1444
The low level of available iron in vivo is a major obstacle for microbial pathogens and is a stimulus for the expression of virulence genes. In this study, Mycobacterium tuberculosis H37Rv was grown aerobically in the presence of limited iron availab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b93806edbfecb8abebdfc2408ebe42f
https://doi.org/10.1099/mic.0.2006/004317-0
https://doi.org/10.1099/mic.0.2006/004317-0
Autor:
Nilu Goonetilleke, Andrzej Pawlowski, Kim A. Hatch, Graham J. Hatch, Peter Andersen, T. Mark Doherty, Ann Williams, Wilfried Dalemans, Helen McShane, Karen E. Gooch, Kris Huygen, Stefan H. E. Kaufmann, Karen Blake, Douglas B. Lowrie, Stewart T. Cole, Philip Marsh, Tanya Parish, Simon O. Clark, Alexander S. Pym, Joe Cohen, Gunilla Källenius, Priscille Brodin, Carlos Martin, Brigitte Gicquel, Kees L. M. C. Franken, Stefan B. Svenson, Yves Lobet, Debbie A. Smith, Peter Seiler, Graham Hall, Neil G. Stoker, Adrian V. S. Hill, Leander Grode, Tom H. M. Ottenhoff
Publikováno v:
Tuberculosis. 85:29-38
The TB Vaccine Cluster project funded by the EU Fifth Framework programme aims to provide novel vaccines against tuberculosis that are suitable for evaluation in humans. This paper describes the studies of the protective efficacy of vaccines in a gui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b7242e4b1916d57971b66d45c0586d
https://doi.org/10.1016/j.tube.2004.09.009
https://doi.org/10.1016/j.tube.2004.09.009
Autor:
Joanna, Bacon, Kim A, Hatch
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 465
Batch cultures have predominately been used for the study of physiology and gene expression in mycobacteria. This chapter describes the assembly of chemostats and the methodology that is being used for growing Mycobacterium tuberculosis in continuous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::905f75e2e623c1ed0465976ab45a2f1d
https://pubmed.ncbi.nlm.nih.gov/20560079
https://pubmed.ncbi.nlm.nih.gov/20560079
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 642
The ability of all pathogens to survive within the host is key to their success in establishing disease. Environmental conditions that affect the growth of a pathogen in the host include nutrient status, environmental pH, oxygen availability, and hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4627211947514c06e6fe7f6f8e9af9f8
https://pubmed.ncbi.nlm.nih.gov/20401591
https://pubmed.ncbi.nlm.nih.gov/20401591