Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Kim A. O’Neill"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Chimeric antigen receptor (CAR) T cell therapy has become an important treatment for hematological cancers, and its success has spurred research into CAR T cell therapies for other diseases, including solid tumor cancers and autoimmune diseases. Nota
Externí odkaz:
https://doaj.org/article/017f6d0038bb4ce7b525fc2fead81864
Autor:
Eliza E. Bitter, Jonathan Skidmore, Carolyn I. Allen, Rachel I. Erickson, Rachel M. Morris, Toni Mortimer, Audrey Meade, Rachel Brog, Tim Phares, Michelle Townsend, Brett E. Pickett, Kim L. O’Neill
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/ac0042594a5e45e1b45dfc75988262ba
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6835 (2023)
Graves’ disease (GD) is a thyroid-specific autoimmune disease with a high prevalence worldwide. The disease is primarily mediated by B cells, which produce autoantibodies against the thyroid-stimulating hormone receptor (TSHR), chronically stimulat
Externí odkaz:
https://doaj.org/article/d58db28de728461c88897273a876b6b2
Publikováno v:
Cell & Bioscience, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and disease progression. TK1 is involve
Externí odkaz:
https://doaj.org/article/6fc14cad9de6445aad0fc2c1c23a6cac
Autor:
Michelle H. Townsend, Zac E. Ence, Taylor P. Cox, John E. Lattin, Weston Burrup, Michael K. Boyer, Stephen R. Piccolo, Richard A. Robison, Kim L. O’Neill
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background The aim of this study is to determine whether Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) could be used as a biomarker for the diagnosis and treatment of B cell malignancies. With 4.3% of all new cancers diagnosed as Non
Externí odkaz:
https://doaj.org/article/67a3eff2e7cf4eb580f334fd9da89878
Autor:
Edwin J. Velazquez, Taylor D. Brindley, Gajendra Shrestha, Eliza E. Bitter, Jordan D. Cress, Michelle H. Townsend, Bradford K. Berges, Richard A. Robison, K. Scott Weber, Kim L. O’Neill
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-20 (2020)
Abstract Background Thymidine kinase 1 (TK1) is a pyrimidine salvage pathway enzyme that is up-regulated in malignant tissues and elevated in the serum of cancer patients. While TK1 has been well established as a tumor biomarker, little has been done
Externí odkaz:
https://doaj.org/article/ce40312a18834b01b2066911b7b8d49a
Autor:
Edwin J. Velazquez, Jordan D. Cress, Tyler B. Humpherys, Toni O. Mortimer, David M. Bellini, Jonathan R. Skidmore, Kathryn R. Smith, Richard A. Robison, Scott K. Weber, Kim L. O’Neill
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Thymidine Kinase 1 (TK1) is primarily known as a cancer biomarker with good prognostic capabilities for both hematological and solid malignancies. However, recent studies targeting TK1 at protein and mRNA levels have shown that TK1 may be useful as a
Externí odkaz:
https://doaj.org/article/e26492d81b7a42d3ae8a247678f6c343
Autor:
Michelle H. Townsend, Abigail M. Felsted, Zac E. Ence, Stephen R. Piccolo, Richard A. Robison, Kim L. O’Neill
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 2, Pp 1-10 (2019)
HPRT is a housekeeping enzyme involved in recycling guanine and inosine in the purine salvage pathway. As a housekeeping gene, HPRT has been widely used as an endogenous control for molecular studies evaluating changes in gene expression. Yet, recent
Externí odkaz:
https://doaj.org/article/fcba7383230242058ab0e332506342b9
Autor:
Michelle H. Townsend, Zac E. Ence, Abigail M. Felsted, Alyssa C. Parker, Stephen R. Piccolo, Richard A. Robison, Kim L. O’Neill
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-18 (2019)
Abstract Background Incidence of endometrial cancer are rising both in the United States and worldwide. As endometrial cancer becomes more prominent, the need to develop and characterize biomarkers for early stage diagnosis and the treatment of endom
Externí odkaz:
https://doaj.org/article/14e17277c61d421ab95c767ed48d207a
Autor:
Evita G. Weagel, Weston Burrup, Roman Kovtun, Edwin J. Velazquez, Abigail M. Felsted, Michelle H. Townsend, Zachary E. Ence, Erica Suh, Stephen R. Piccolo, K. Scott Weber, Richard A. Robison, Kim L. O’Neill
Publikováno v:
Cancer Cell International, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Lung, breast, and colorectal malignancies are the leading cause of cancer-related deaths in the world causing over 2.8 million cancer-related deaths yearly. Despite efforts to improve prevention methods, early detection, and treat
Externí odkaz:
https://doaj.org/article/19a1ea04c5ef44dc9c6502688b1a429a