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Akademický článek

Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D

Autor: Ece Canan Sayitoglu, Anna-Maria Georgoudaki, Michael Chrobok, Didem Ozkazanc, Benjamin J. Josey, Muhammad Arif, Kim Kusser, Michelle Hartman, Tamara M. Chinn, Renee Potens, Cevriye Pamukcu, Robin Krueger, Cheng Zhang, Adil Mardinoglu, Evren Alici, Harry Thomas Temple, Tolga Sutlu, Adil Doganay Duru

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Sarcomas are malignancies of mesenchymal origin that occur in bone and soft tissues. Many are chemo- and radiotherapy resistant, thus conventional treatments fail to increase overall survival. Natural Killer (NK) cells exert anti-tumor activity upon

Externí odkaz: https://doaj.org/article/7661b8daeda441778d5cd52335100e15

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The development of inducible bronchus-associated lymphoid tissue depends on IL-17

Autor: Maria de la Luz Garcia-Hernandez, Troy D. Randall, Kim Kusser, Javier Rangel-Moreno, Jay K. Kolls, Louise Hartson, Shabaana A. Khader, Damian M. Carragher, Ji Young Hwang

Publikováno v: Nature Immunology. 12:639-646

Ectopic or tertiary lymphoid tissues, such as inducible bronchus-associated lymphoid tissue (iBALT), form in nonlymphoid organs after local infection or inflammation. However, the initial events that promote this process remain unknown. Here we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6519d4df1eb5dd009bfcc1da69948d4d
https://doi.org/10.1038/ni.2053

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Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity

Autor: Marilyn R. Kehry, Troy D. Randall, Miguel E. Moreno-García, Kim Kusser, David J. Rawlings, Guixiu Shi, Shirly Becker-Herman, Kelly L. Hudkins, Melvin I. Simon, Denny Liggitt, Michael Tighe, Robert Dunn, Ann Marshak-Rothstein, Betty Mousseau, Ravi S. Misra, Charles E. Alpers, Frances E. Lund, Thi Sau Migone, Anil Thankappan

Publikováno v: The Journal of Experimental Medicine

Survival of mature B cells is regulated by B cell receptor and BAFFR-dependent signals. We show that B cells from mice lacking the Gαq subunit of trimeric G proteins (Gnaq−/− mice) have an intrinsic survival advantage over normal B cells, even i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b10f183ff6fa9900d4bf5fd00b4214e
https://doi.org/10.1084/jem.20092735

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B Cells Promote Resistance to Heterosubtypic Strains of Influenza via Multiple Mechanisms

Autor: Amy Moquin, Louise Hartson, Frances E. Lund, Damian M. Carragher, Ravi S. Misra, Troy D. Randall, Kim Kusser, Javier Rangel-Moreno

Publikováno v: The Journal of Immunology. 180:454-463

Immunity to heterosubtypic strains of influenza is thought to be mediated primarily by memory T cells, which recognize epitopes in conserved proteins. However, the involvement of B cells in this process is controversial. We show in this study that in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86306b9e00906b37cd209f2dda6f6e0c
https://doi.org/10.4049/jimmunol.180.1.454

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Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza

Autor: Louise Hartson, Troy D. Randall, Kim Kusser, Javier Rangel-Moreno, Juan Moyron-Quiroz

Publikováno v: Proceedings of the National Academy of Sciences. 104:10577-10582

CXC chemokine ligand 13 (CXCL13), CC chemokine ligand 21 (CCL21), and CCL19 are constitutively expressed in secondary lymphoid organs, where they control the placement of lymphocytes and dendritic cells. However, these chemokines are also inducibly e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d5705876c5af3d5cbd16206c6c9a00
https://doi.org/10.1073/pnas.0700591104

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Suppressed Insulin Signaling and Increased Apoptosis inCd38-Null Islets

Autor: Eric L. Ford, Frances E. Lund, Hung Tran, Dan S. Luciani, Kenneth S. Polonsky, Troy D. Randall, Kim Kusser, Ernesto Bernal-Mizrachi, Zhiqiang Han, James D. Johnson

Publikováno v: Diabetes. 55:2737-2746

CD38 is a multifunctional enzyme capable of generating metabolites that release Ca 2+ from intracellular stores, including nicotinic acid adenine dinucleotide phosphate (NAADP). A number of studies have led to the controversial proposal that CD38 med

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d2f47db7f82fe915706f66f8d63927
https://doi.org/10.2337/db05-1455

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Simultaneous Detection of EGFP and Cell Surface Markers by Fluorescence Microscopy in Lymphoid Tissues

Autor: Troy D. Randall, Kim Kusser

Publikováno v: Journal of Histochemistry & Cytochemistry. 51:5-14

Enhanced GFP (EGFP) is a powerful tool for the visualization of tagged proteins and transfected cells and is easily detected by fluorescence microscopy or flow cytometry in living cells. However, soluble EGFP molecules can be lost if cell integrity i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3523d0d0b7147f13595ee5e189cecd3c
https://doi.org/10.1177/002215540305100102

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Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo

Autor: Allen G. Harmsen, Maureen Howard, Simon Monard, Santiago Partida-Sanchez, Debra A. Cockayne, Stephen Goodrich, Elaine L. Jacobson, Troy D. Randall, Kim Kusser, Frances E. Lund, Norman J. Oppenheimer, Beth A. Garvy

Publikováno v: Nature Medicine. 7:1209-1216

Cyclic ADP-ribose is believed to be an important calcium-mobilizing second messenger in invertebrate, mammalian and plant cells. CD38, the best-characterized mammalian ADP-ribosyl cyclase, is postulated to be an important source of cyclic ADP-ribose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c38be7b8d31265294e01654ac277b05
https://doi.org/10.1038/nm1101-1209

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Colonic patch and colonic SILT development are independent and differentially regulated events

Autor: António P. Baptista, Marlene Knippenberg, Reina E. Mebius, A Lugering, Gera Goverse, Rita G. Domingues, Henrique Veiga-Fernandes, Andrew D. Luster, Mascha Greuter, Troy D. Randall, Kim Kusser, Tom Cupedo, Brenda J. Olivier

Publikováno v: Mucosal Immunology
Mucosal Immunology, 6(3), 511-521. Nature Publishing Group
Baptista, A P, Olivier, B J, Goverse, G, Greuter, M, Knippenberg, M, Kusser, K, Domingues, R G, Veiga-Fernandes, H, Luster, A D, Lugering, A, Randall, TD, Cupedo, T & Mebius, R E 2013, ' Colonic patch and colonic SILT development are independent and differentially regulated events ', Mucosal Immunology, vol. 6, no. 3, pp. 511-521 . https://doi.org/10.1038/mi.2012.90
Mucosal immunology

Intestinal lymphoid tissues have to simultaneously ensure protection against pathogens and tolerance toward commensals. Despite such vital functions, their development in the colon is poorly understood. Here, we show that the two distinct lymphoid ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d47ee7056c26dc3c1134ae7213ad7a6

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Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation

Autor: Troy D. Randall, Kim Kusser, William W. Agace, Serge A. van de Pavert, Gera Goverse, Karen Niederreither, Reina E. Mebius, Mark F. R. Vondenhoff, Mascha Greuter, Brenda J. Olivier, Patrick Beke, Rune Blomhoff, Martin Lipp, Uta E. Höpken, Kasia Sitnik, Wouter J. de Jonge

Publikováno v: Nature immunology, 10(11), 1193-1199. Nature Publishing Group
van de Pavert, S A, Olivier, B J, Goverse, G, Vondenhoff, M F R, Greuter, M J, Beke, P, Kusser, K, Hopken, U E, Lipp, M, Niederreither, K, Blomhoff, R, Sitnik, K, Agace, W W, Randall, TD, Jonge, W & Mebius, R E 2009, ' Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation ', Nature Immunology, vol. 10, no. 11, pp. 1193-1U78 . https://doi.org/10.1038/ni.1789
Nature Immunology, 10(11), 1193-1U78. Nature Publishing Group
Nature immunology

The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9af33b53f608c48046e499d872ed3e5
https://pure.amc.nl/en/publications/chemokine-cxcl13-is-essential-for-lymph-node-initiation-and-is-induced-by-retinoic-acid-and-neuronal-stimulation(f96217e1-3767-4eef-a28f-476990955c86).html

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