Additional file 1 of Extru-seq: a method for predicting genome-wide Cas9 off-target sites with advantages of both cell-based and in vitro approaches

Autor: Kwon, Jeonghun, Kim, Minyoung, Hwang, Woochang, Jo, Anna, Hwang, Gue-Ho, Jung, Minhee, Kim, Un Gi, Cui, Gang, Kim, Heonseok, Eom, Joon-Ho, Hur, Junho K., Lee, Junwon, Kim, Youngho, Kim, Jin-soo, Bae, Sangsu, Lee, Jungjoon K.

Additional file 1: Fig. S1. Genome editing drugs and off-target prediction methods used in IND studies. Fig. S2. Optimization of Extru-seq conditions. Fig. S3. Extru-seq WGS data analyzed using IGV to reveal cleavage patterns. Fig. S4. Genome-wide of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bcce80c3723f2a2c819037f2b2b117

Additional file 3 of Extru-seq: a method for predicting genome-wide Cas9 off-target sites with advantages of both cell-based and in vitro approaches

Autor: Kwon, Jeonghun, Kim, Minyoung, Hwang, Woochang, Jo, Anna, Hwang, Gue-Ho, Jung, Minhee, Kim, Un Gi, Cui, Gang, Kim, Heonseok, Eom, Joon-Ho, Hur, Junho K., Lee, Junwon, Kim, Youngho, Kim, Jin-soo, Bae, Sangsu, Lee, Jungjoon K.

Additional file 3: Table S2. Manually validated off-target sites from Extru-seq WGS data visualized using IGV.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90f044cb120fc865bde6fa3b6569ab8

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Single cell and spatial alternative splicing analysis with long read sequencing.

Autor: Fu Y; Graduate Program in Genomics and Computational Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Kim H; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Adams JI; Graduate Program in Genomics and Computational Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Grimes SM; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Huang S; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA., Lau BT; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Sathe A; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Hess P; Department of Statistics, University of Pennsylvania, Philadelphia, PA, USA., Ji HP; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Zhang NR; Graduate Program in Genomics and Computational Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Statistics, University of Pennsylvania, Philadelphia, PA, USA.

Publikováno v: Research square [Res Sq] 2023 Mar 21. Date of Electronic Publication: 2023 Mar 21.