Tocilizumab in hospitalized patients with COVID-19: Clinical outcomes, inflammatory marker kinetics, safety, and a review of the literature

Autor: Mark M. Wurfel, Cameron J. Turtle, Jing Huang, Margaret L. Green, Danika Bethune, Christine Johnston, Kim Hn, Manoj Menon, Guang-Shing Cheng, Wendy M. Leisenring, Joshua A. Hill, Shireesha Dhanireddy, Hu Xie, Jeannie D. Chan, Rupali Jain

BackgroundCoronavirus disease 2019 (COVID-19) due to infection with SARS-CoV-2 causes substantial morbidity. Tocilizumab, an interleukin-6 receptor antagonist, might improve outcomes by mitigating inflammation.MethodsWe conducted a retrospective stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df668f1f6f44f102d6b66484bab2076

Centrality Dependence of the Charged-Particle Multiplicity Density at Midrapidity in Pb-Pb Collisions at root s(NN)=2.76 TeV

Autor: Aamodt, K, Soramel, Francesca, Adamova, D, Adare, Am, Aggarwal, Mm, Rinella, Ga, Agocs, Ag, Salazar, Sa, Ahammed, Z, Ahmad, N, Masoodi, Aa, Ahn, Su, Akindinov, A, Aleksandrov, D, Alessandro, B, Molina, Ra, Alici, A, Alkin, A, Avina, Ea, Alt, T, Altini, V, Altinpinar, S, Altsybeev, I, Andrei, C, Andronic, A, Anguelov, V, Anson, C, Anticic, T, Antinori, F, Antonioli, P, Aphecetche, L, Appelshauser, H, Arbor, N, Arcelli, S, Arend, A, Armesto, N, Arnaldi, R, Aronsson, T, Arsene, Ic, Asryan, A, Augustinus, A, Averbeck, R, Awes, Tc, Aysto, J, Azmi, Md, Bach, M, Badala, A, Baek, Yw, Bagnasco, S, Bailhache, R, Bala, R, Ferroli, Rb, Baldisseri, A, Baldit, A, Ban, J, Barbera, R, Barile, F, Barnafoldi, Gg, Barnby, Ls, Barret, V, Bartke, J, Basile, M, Bastid, N, Bathen, B, Batigne, G, Batyunya, B, Baumann, C, Bearden, Ig, Beck, H, Belikov, I, Bellini, F, Bellwied, R, BELMONT MORENO, E, Beole, S, Berceanu, I, Bercuci, A, Berdermann, E, Berdnikov, Y, Betev, L, Bhasin, A, Bhati, Ak, Bianchi, L, Bianchi, N, Bianchin, C, Bielcik, J, Bielcikova, J, Bilandzic, A, Biolcati, E, Blanc, A, Blanco, F, Blau, D, Blume, C, Boccioli, M, Bock, N, Bogdanov, A, Boggild, H, Bogolyubsky, M, Boldizsar, L, Bombara, M, Bombonati, C, Book, J, Borel, H, Bortolin, C, Bose, S, Bossu, F, Botje, M, Bottger, S, Boyer, B, BRAUN MUNZINGER, P, Bravina, L, Bregant, M, Breitner, T, Broz, M, Brun, R, Bruna, E, Bruno, Ge, Budnikov, D, Buesching, H, Busch, O, Buthelezi, Z, Caffarri, Davide, Cai, X, Caines, H, Villar, Ec, Camerini, P, Roman, Vc, Romeo, Gc, Carena, F, Carena, W, Carminati, F, Diaz, Ac, Caselle, M, Castellanos, Jc, Catanescu, V, Cavicchioli, C, Cerello, P, Chang, B, Chapeland, S, Charvet, Jl, Chattopadhyay, S, Cherney, M, Cheshkov, C, Cheynis, B, Chiavassa, E, Barroso, Vc, Chinellato, Dd, Chochula, P, Chojnacki, M, Christakoglou, P, Christensen, Ch, Christiansen, P, Chujo, T, Cicalo, C, Cifarelli, L, Cindolo, F, Cleymans, J, Coccetti, F, Coffin, Jp, Coli, S, Balbastre, Gc, DEL VALLE ZC, Constantin, P, Contin, G, Contreras, Jg, Cormier, Tm, Morales, Yc, Maldonado, Ic, Cortese, P, Cosentino, Mr, Costa, F, Cotallo, Me, Crescio, E, Crochet, P, Cuautle, E, Cunqueiro, L, Erasmo, Gd, Dainese, A, Dalsgaard, Hh, Danu, A, Das, D, Das, I, Dash, A, Dash, S, De, S, Moregula, Ad, DE BARROS GOV, DE CARO, A, DE CATALDO, G, DE CUVELAND, J, DE FALCO, A, DE GRUTTOLA, D, DE MARCO, N, DE PASQUALE, S, DE REMIGIS, R, DE ROOIJ, R, Delagrange, H, Mercado, Yd, Dellacasa, G, Deloff, A, Demanov, V, Denes, E, Deppman, A, DI BARI, D, DI GIGLIO, C, DI LIBERTO, S, DI MAURO, A, DI NEZZA, P, Dietel, T, Divia, R, Djuvsland, O, Dobrin, A, Dobrowolski, T, Dominguez, I, Donigus, B, Dordic, O, Driga, O, Dubey, Ak, Ducroux, L, Dupieux, P, Majumdar, Akd, Majumdar, Mrd, Elia, D, Emschermann, D, Engel, H, Erdal, Ha, Espagnon, B, Estienne, M, Esumi, S, Evans, D, Evrard, S, Eyyubova, G, Fabjan, Cw, Fabris, D, Faivre, J, Falchieri, D, Fantoni, A, Fasel, M, Fearick, R, Fedunov, A, Fehlker, D, Fekete, V, Felea, D, Feofilov, G, Tellez, Af, Ferretti, A, Ferretti, R, Figueredo, Mas, Filchagin, S, Fini, R, Finogeev, D, Fionda, Fm, Fiore, Em, Floris, M, Foertsch, S, Foka, P, Fokin, S, Fragiacomo, E, Fragkiadakis, M, Frankenfeld, U, Fuchs, U, Furano, F, Furget, C, Girard, Mf, Gaardhoje, Jj, Gadrat, S, Gagliardi, M, Gago, A, Gallio, M, Ganoti, P, Garabatos, C, Gemme, R, Gerhard, J, Germain, M, Geuna, C, Gheata, A, Gheata, M, Ghidini, B, Ghosh, P, Girard, Mr, Giraudo, G, Giubellino, P, GLADYSZ DZIADUS, E, Glassel, P, Gomez, R, GONZALEZ TRUEBA LH, GONZALEZ ZAMORA, P, Santos, Hg, Gorbunov, S, Gotovac, S, Grabski, V, Grajcarek, R, Grelli, A, Grigoras, A, Grigoras, C, Grigoriev, V, Grigoryan, A, Grigoryan, S, Grinyov, B, Grion, N, Gros, P, GROSSE OETRINGHAUS JF, Grossiord, Jy, Grosso, R, Guber, F, Guernane, R, Gutierrez, Cg, Guerzoni, B, Gulbrandsen, K, Gulkanyan, H, Gunji, T, Gupta, A, Gupta, R, Gutbrod, H, Haaland, O, Hadjidakis, C, Haiduc, M, Hamagaki, H, Hamar, G, Harris, Jw, Hartig, M, Hasch, D, Hasegan, D, Hatzifotiadou, D, Hayrapetyan, A, Heide, M, Heinz, M, Helstrup, H, Herghelegiu, A, Hernandez, C, Corral, Gh, Herrmann, N, Hetland, Kf, Hicks, B, Hille, Pt, Hippolyte, B, Horaguchi, T, Hori, Y, Hristov, P, Hrivnacova, I, Huang, M, Huber, S, Humanic, Tj, Hwang, Ds, Ichou, R, Ilkaev, R, Ilkiv, I, Inaba, M, Incani, E, Innocenti, Gm, Innocenti, Pg, Ippolitov, M, Irfan, M, Ivan, C, Ivanov, A, Ivanov, M, Ivanov, V, Jacholkowski, A, Jacobs, Pm, Jancurova, L, Jangal, S, Janik, R, Jayarathna, Sp, Jena, S, Jirden, L, Jones, Gt, Jones, Pg, Jovanovic, P, Jung, H, Jung, W, Jusko, A, Kalcher, S, Kalinak, P, Kalisky, M, Kalliokoski, T, Kalweit, A, Kamermans, R, Kanaki, K, Kang, E, Kang, Jh, Kaplin, V, Karavichev, O, Karavicheva, T, Karpechev, E, Kazantsev, A, Kebschull, U, Keidel, R, Khan, Mm, Khanzadeev, A, Kharlov, Y, Kileng, B, Kim, Dj, Kim, Ds, Kim, Dw, Kim, Hn, Kim, Jh, Kim, Js, Kim, M, Kim, S, Kim, Sh, Kirsch, S, Kisel, I, Kiselev, S, Kisiel, A, Klay, Jl, Klein, J, KLEIN BOSING, C, 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A, Mager, M, Mahapatra, Dp, Maire, A, Malaev, M, Cervantes, Im, Mal'Kevich, D, Malzacher, P, Mamonov, A, Manceau, L, Mangotra, L, Manko, V, Manso, F, Manzari, V, Mao, Y, Mares, J, Margagliotti, Gv, Margotti, A, Marin, A, Martashvili, I, Martinengo, P, Martinez, Mi, Davalos, Am, Garcia, Gm, Martynov, Y, Mas, A, Masciocchi, S, Masera, M, Masoni, A, Massacrier, L, Mastromarco, M, Mastroserio, A, Matthews, Zl, Matyja, A, Mayani, D, Mazza, G, Mazzoni, Ma, Meddi, F, MENCHACA ROCHA, A, Lorenzo, Pm, Perez, Jm, Mereu, P, Miake, Y, Midori, J, Milano, L, Milosevic, J, Mischke, A, Miskowice, D, Mitu, C, Mlynarz, J, Mohanty, B, Molnar, L, Zetina, Lm, Monteno, M, Montes, E, Morando, Maurizio, DE GODOY DAM, Moretto, Sandra, Morsch, A, Muccifora, V, Mudnic, E, Muller, H, Muhuri, S, Munhoz, Mg, Munoz, J, Musa, L, Musso, A, Nandi, Bk, Nania, R, Nappi, E, Nattrass, C, Navach, F, Navin, S, Nayak, Tk, Nazarenko, S, Nazarov, G, Nedosekin, A, Nendaz, F, Newby, J, Nicassio, M, Nielsen, Bs, Nikolaev, S, 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Ca, Pshenichnov, I, Puddu, G, Pulvirenti, A, Punin, V, Putis, M, Putschke, J, Quercigh, E, Qvigstad, H, Rachevski, A, Rademakers, A, Rademakers, O, Radomski, S, Raiha, Ts, Rak, J, Rakotozafindrabe, A, Ramello, L, Reyes, Ar, Rammler, M, Raniwala, R, Raniwala, S, Rasanen, Ss, Read, Kf, Real, Js, Redlich, K, Renfordt, R, Reolon, Ar, Reshetin, A, Rettig, F, Revol, Jp, Reygers, K, Ricaud, H, Riccati, L, Ricci, Ra, Richter, M, Riedler, P, Riegler, W, Riggi, F, Rivetti, A, Cahuantzi, Mr, Rohr, D, Rohrich, D, Romita, R, Ronchetti, F, Rosinsky, P, Rosnet, P, Rossegger, S, Rossi, A, Roukoutakis, F, Rousseau, S, Roy, C, Roy, P, Montero, Ajr, Rui, R, Rusanov, I, Ryabinkin, E, Rybicki, A, Sadovsky, S, Safarik, K, Sahoo, R, Sahu, Pk, Saiz, P, Sakai, S, Sakata, D, Salgado, Ca, Samanta, T, Sambyal, S, Samsonov, V, Sandor, L, Sandoval, A, Sano, M, Sano, S, Santo, R, Santoro, R, Sarkamo, J, Saturnini, P, Scapparone, E, Scarlassara, Fernando, Scharenberg, Rp, Schiaua, C, Schicker, R, Schmidt, C, Schmidt, 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Physical Review Letters. Amer Physical Soc, v. 106, n. 3, 2011.
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The centrality dependence of the charged-particle multiplicity density at mid-rapidity in Pb-Pb collisions at $\sqrt{s_{NN}}$ = 2.76 TeV is presented. The charged-particle density normalized per participating nucleon pair increases by about a factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::177904e6af040fcb7d777720969534d2
http://hdl.handle.net/10852/58726

Branched oligomerization of cell-permeable peptides markedly enhances the transduction efficiency of adenovirus into mesenchymal stem cells

Autor: Song My, Lee Zh, Chung Yj, Yang D, Seo Sh, Kim Hn, Kwan Yong Choi, Lim Cl, Lee Hy, Su-Hyung Park, Je-Min Choi, Kim Sm, Lee Sk, Youn Ji, Park Si, Jin Ht, Junsang Doh, Sung Yc, Jeun Ss, Sung Sy, Kim M, Hwang Sj, Lim Jy

Publikováno v: Gene therapy. 17(8)

Cell-permeable peptides (CPPs) promote the transduction of nonpermissive cells by recombinant adenovirus (rAd) to improve the therapeutic efficacy of rAd. In this study, branched oligomerization of CPPs significantly enhanced the transduction of huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5141a7022e3ce83fee5e451548896250
https://pubmed.ncbi.nlm.nih.gov/20485381

Midrapidity antiproton-to-proton ratio in pp collisons root s=0.9 and 7 TeV measured by the ALICE experiment

Autor: Aamodt, Kenneth, Abel, N, Abeysekara, U, Quintana, A. 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Externí odkaz: http://hdl.handle.net/11250/2482051

Transverse momentum spectra of charged particles in proton-proton collisions at root s=900 GeV with ALICE at the LHC

Autor: Aamodt, Kenneth, Abel, N, Abeysekara, U, Quintana, AA, Abramyan, A, Adamova, D, Aggarwal, MM, Rinella, GA, Agocs, AG, Salazar, SA, Ahammed, Z, Ahmad, A, Ahmad, N, Ahn, SU, Akimoto, R, Akindinov, A, Aleksandrov, D, Alessandro, B, Molina, RA, Alici, A, Avina, EA, Alme, Johan, Alt, T, Altini, V, Altinpinar, S, Andrei, C, Andronic, A, Anelli, G, Angelov, V, Anson, C, Anticic, T, Antinori, F, Antinori, S, Antipin, K, Antonczyk, D, Antonioli, P, Anzo, A, Aphecetche, L, Appelshauser, H, Arcelli, S, Arceo, R, Arend, A, Armesto, N, Arnaldi, R, Aronsson, T, Arsene, Ionut Christian, Asryan, A, Augustinus, A, Averbeck, R, Awes, TC, Aysto, J, Azmi, MD, Bablok, Sebastian Robert, Bach, M, Badala, A, Baek, YW, Bagnasco, S, Baihache, R, Bala, R, Baldisseri, A, Baldit, A, Ban, J, Barbera, R, Barnafoldi, GG, Barnby, L, Barret, V, Bartke, J, Barile, F, Basile, M, Basmanov, V, Bastid, N, Bathen, B, Batigne, G, Batyunya, B, Baumann, C, Bearden, IG, Becker, B, Belikov, I, Bellwied, R, Belmont-Moreno, E, Belogianni, A, Benhabib, L, Beole, S, Berceanu, I, Bercuci, A, Berdermann, E, Berdnikov, Y, Betev, L, Bhasin, A, Bhati, AK, Bianchi, L, Bianchi, N, Bianchin, C, Bielcik, J, Bielcikova, J, Bilandzic, A, Bimbot, L, Biolcati, E, Blanc, A, Blanco, F, Blau, D, Blume, C, Boccioli, M, Bock, N, Bogdanov, A, Boggild, H, Bogolyubsky, M, Bohm, J, Boldizsar, L, Bombara, M, Bombonati, C, Bondila, M, Borel, H, Borisov, A, Bortolin, C, Bose, S, Bosisio, L, Bossu, F, Botje, M, Bottger, S, Bourdaud, G, Boyer, B, Braun, M, Braun-Munzinger, R, Bravina, Larissa, Bregant, M, Breitner, T, Bruckner, G, Brun, R, Bruna, E, Bruno, GE, Budnikov, D, Buesching, H, Buncic, P, Busch, O, Buthelezi, Z, Caffarri, D, Cai, X, Caines, H, Calvo, E, Camacho, E, Camerini, P, Campbell, M, Roman, VC, Capitani, GP, Romeo, GC, Carena, F, Carena, W, Carminati, F, Diaz, AC, Caselle, M, Castellanos, JC, Hernandez, JFC, Catanescu, V, Cattaruzza, E, Cavicchioli, C, Cerello, P, Chambert, V, Chang, B, Chapeland, S, Charpy, A, Charvet, JL, Chattopadhyay, S, Cherney, M, Cheshkov, C, Cheynis, B, Chiavassa, E, Barroso, VC, Chinellato, DD, Chochula, P, Choi, K, Chojnacki, M, Christakoglou, P, Christensen, CH, Christiansen, P, Chujo, T, Chuman, F, Cicalo, C, Cifarelli, L, Cindolo, F, Cleymans, J, Cobanoglu, O, Coffin, JP, Coli, S, Colla, A, Balbastre, GC, del Valle, ZC, Conner, ES, Constantin, P, Contin, G, Contreras, JG, Morales, YC, Cormier, TM, Cortese, P, Maldonado, IC, Cosentino, MR, Costa, F, Cotallo, ME, Crescio, E, Crochet, P, Cuautle, E, Cunqueiro, L, Cussonneau, J, Dainese, A, Dalsgaard, HH, Danu, A, Das, I, Dash, A, Dash, S, de Barros, GOV, De Caro, A, de Cataldo, G, de Cuveland, J, De Falco, A, De Gaspari, M, de Groot, J, De Gruttola, D, De Marco, N, De Pasquale, S, De Remigis, R, de Rooij, R, de Vaux, G, Delagrange, H, Delgado, Y, Dellacasa, G, Deloff, A, Demanov, V, Denes, E, Deppman, A, D'Erasmo, G, Derkach, D, Devaux, A, Di Bari, D, Di Giglio, C, Di Liberto, S, Di Mauro, A, Di Nezza, P, Dialinas, M, Diaz, L, Diaz, R, Dietel, T, Divia, R, Djuvsland, Øystein, Dobretsov, V, Dobrin, A, Dobrowolski, T, Donigus, B, Dominguez, I, Don, DMM, Dordic, Olja, Dubey, AK, Dubuisson, J, Ducroux, L, Dupieux, P, Majumdar, AKD, Majumdar, MRD, Elia, D, Emschermann, D, Enokizono, A, Espagnon, B, Estienne, M, Esumi, S, Evans, D, Evrard, S, Eyyubova, Gyulnara, Fabjan, CW, Fabris, D, Faivre, J, Falchieri, D, Fantoni, A, Fasel, M, Fateev, O, Fearick, R, Fedunov, A, Fehlker, Dominik, Fekete, V, Felea, D, Fenton-Olsen, B, Feofilov, G, Tellez, AF, Ferreiro, EG, Ferretti, A, Ferretti, R, Figueredo, MAS, Filchagin, S, Fini, R, Fionda, FM, Fiore, EM, Floris, M, Fodor, Z, Foertsch, S, Foka, P, Fokin, S, Formenti, F, Fragiacomo, E, Fragkiadakis, M, Frankenfeld, U, Frolov, A, Fuchs, U, Furano, F, Furget, C, Girard, MF, Gaardhoje, JJ, Gadrat, S, Gagliardi, M, Gago, A, Gallio, M, Ganoti, P, Ganti, MS, Garabatos, C, Trapaga, CG, Gebelein, J, Gemme, R, Germain, M, Gheata, A, Gheata, M, Ghidini, B, Ghosh, P, Giraudo, G, Giubellino, P, Gladysz-Dziadus, E, Glasow, R, Glassel, R, Glenn, A, Jimenez, RG, Santos, HG, Gonzalez-Trueba, LH, Gonzalez-Zamora, P, Gorbunov, S, Gorbunov, Y, Gotovac, S, Gottschlag, H, Grabski, V, Grajcarek, R, Grelli, A, Grigoras, A, Grigoras, C, Grigoriev, V, Grigoryan, A, Grigoryan, S, Grinyov, B, Grion, N, Gros, P, Grosse-Oetringhaus, JF, Grossiord, JY, Grosso, R, Guber, F, Guernane, R, Guerra, C, Guerzoni, B, Gulbrandsen, K, Gulkanyan, H, Gunji, T, Gupta, A, Gupta, R, Gustafsson, HA, Gutbrod, H, Haaland, Øystein Senneset, Hadjidakis, C, Haiduc, M, Hamagaki, H, Hamar, G, Hamblen, J, Han, BH, Harris, JW, Hartig, M, Harutyunyan, A, Hasch, D, Hasegan, D, Hatzifotiadou, D, Hayrapetyan, A, Heide, M, Heinz, M, Helstrup, Håvard, Herghelegiu, A, Hernandez, C, Corral, GH, Herrmann, N, Hetland, Kristin Fanebust, Hicks, B, Hiei, A, Hille, Per Thomas, Hippolyte, B, Horaguchi, T, Hori, Y, Hristov, P, Hrivnacova, I, Hu, S, Huang, Meidana, Huber, S, Humanic, TJ, Hutter, D, Hwang, 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Externí odkaz: http://hdl.handle.net/11250/2482065