Non-invasive strategy: Developing a topical IL-4Rα-specific nanobody for the treatment of allergic airway diseases

Autor: Ahn, Taeyoung, Lee, Dong Hyuk, Kim, GeunAh, Kim, JiHyun, Park, Joon-Sang, Cho, Hyung-Ju, Kim, Joo Young

Publikováno v: In Materials Today Bio August 2024 27

Nicotiana benthamiana-derived dupilumab-scFv reaches deep into the cultured human nasal epithelial cells and inhibits CCL26 expression.

Autor: Kwon BJ; Department of Pharmacology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03080, Republic of Korea., Cho NH; Department of Pharmacology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03080, Republic of Korea.; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03080, Republic of Korea., Ahn T; Department of Pharmacology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03080, Republic of Korea., Kim G; Department of Pharmacology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03080, Republic of Korea., Diệu NTX; Department of Pharmacology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03080, Republic of Korea.; Department of Pharmacognosy, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Kim WT; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03080, Republic of Korea., Cho HJ; Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea., Seo DH; Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03080, Republic of Korea. es1106@yonsei.ac.kr., Kim JY; Department of Pharmacology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03080, Republic of Korea. jooyoungkim@yuhs.ac.

Publikováno v: Scientific reports [Sci Rep] 2024 Jun 24; Vol. 14 (1), pp. 14558. Date of Electronic Publication: 2024 Jun 24.