Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Kim, Brøsen"'
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 6, Pp 1012-1020 (2023)
Abstract Polymorphism of the CYP2D6 gene leads to substantial interindividual variability in CYP2D6 enzyme activity. Despite improvements in prediction of CYP2D6 activity based on genotype information, large interindividual variability within CYP2D6
Externí odkaz:
https://doaj.org/article/d6f63e0330054e3e8fc2ff41f45e2af8
Autor:
Ida Kuhlmann, Amanda Nøddebo Nyrup, Tore Bjerregaard Stage, Mette Marie Hougaard Christensen, Troels Korshøj Bergmann, Per Damkier, Flemming Nielsen, Kurt Højlund, Kim Brøsen
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 6, Pp 2408-2419 (2021)
Abstract The aim of the study was to investigate if there is a clinically relevant drug interaction between metformin and codeine. Volunteers were randomized to receive on four separate occasions: (A) orally administered metformin (1 g), (B) intraven
Externí odkaz:
https://doaj.org/article/b40ce672adc646a18fbe9434186c5a6f
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 983-993 (2021)
Abstract The cytochrome P450 (CYP) 2D6 enzyme exhibits large interindividual differences in metabolic activity. Patients are commonly assigned a CYP2D6 phenotype based on their CYP2D6 genotype, but there is a lack of consensus on how to translate gen
Externí odkaz:
https://doaj.org/article/83eb35e998554e1abe637b04607a27ce
Autor:
Ditte B. Iversen, Ann‐Cathrine Dalgård Dunvald, Daniel M. Jespersen, Flemming Nielsen, Kim Brøsen, Per Damkier, Helen S. Hammer, Oliver Pötz, Erkka Järvinen, Tore B. Stage
Publikováno v:
Clinical Pharmacology & Therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fcd963f9ccc2995268052102734bd8e
https://doi.org/10.1002/cpt.2959
https://doi.org/10.1002/cpt.2959
Autor:
Ida Kuhlmann, Kim Brøsen, Kenn Dornonville de la Cour, Troels K Bergmann, Mette Marie Hougaard Christensen, Tore Bjerregaard Stage, Stine Thorhauge Zwisler, Per Damkier, Anders Gadegaard Jensen, Rasmus Hjelmar Petersen, Flemming Nielsen, Morten Overgaard
Publikováno v:
Kuhlmann, I, Petersen, R H, Overgaard, M, Dornonville de la Cour, K, Zwisler, S, Stage, T B, Christensen, M M H, Bergmann, T K, Damkier, P, Jensen, A G, Nielsen, F & Brøsen, K 2022, ' No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients ', Basic & Clinical Pharmacology & Toxicology, vol. 130, no. 1, pp. 93-102 . https://doi.org/10.1111/bcpt.13667
We investigated the impact of genetic variants in OCT1 (SLC22A1) on morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) pharmacokinetics in adult patients scheduled for major surgery. Blood samples were taken before and 5, 10, 15,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d00b400355041daf5d65f43d1ea4765
https://doi.org/10.1111/bcpt.13667
https://doi.org/10.1111/bcpt.13667
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 983-993 (2021)
Frederiksen, T, Areberg, J, Schmidt, E, Stage, T B & Brøsen, K 2021, ' Cytochrome P450 2D6 genotype–phenotype characterization through population pharmacokinetic modeling of tedatioxetine ', CPT: Pharmacometrics & Systems Pharmacology, vol. 10, no. 9, pp. 983-993 . https://doi.org/10.1002/psp4.12635
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 983-993 (2021)
Frederiksen, T, Areberg, J, Schmidt, E, Stage, T B & Brøsen, K 2021, ' Cytochrome P450 2D6 genotype–phenotype characterization through population pharmacokinetic modeling of tedatioxetine ', CPT: Pharmacometrics & Systems Pharmacology, vol. 10, no. 9, pp. 983-993 . https://doi.org/10.1002/psp4.12635
The cytochrome P450 (CYP) 2D6 enzyme exhibits large interindividual differences in metabolic activity. Patients are commonly assigned a CYP2D6 phenotype based on their CYP2D6 genotype, but there is a lack of consensus on how to translate genotypes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f7610442072fba5a4565c17fd7394a
http://europepmc.org/articles/PMC8452298
http://europepmc.org/articles/PMC8452298
Autor:
Kim Brøsen
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 132:457-458
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a913890a59b2464ea9c9cad830f36586
https://doi.org/10.1111/bcpt.13855
https://doi.org/10.1111/bcpt.13855
Autor:
Kim Brøsen
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 132:3-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54d82e1dbd2bcca31084952cd0ad8a79
https://doi.org/10.1111/bcpt.13819
https://doi.org/10.1111/bcpt.13819
Autor:
Trine Frederiksen, Johan Areberg, Arash Raoufinia, Ellen Schmidt, Tore Bjerregaard Stage, Kim Brøsen
Publikováno v:
Clinical pharmacology and therapeutics.
Accurate prediction of CYP2D6 phenotype from genotype information is important to support safe and efficacious pharmacotherapy with CYP2D6 substrates. To facilitate accurate CYP2D6 genotype-phenotype translation, there remains a need to investigate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6d76c500eddc90979b5dab1fc5ca4d
https://pubmed.ncbi.nlm.nih.gov/36350097
https://pubmed.ncbi.nlm.nih.gov/36350097
Autor:
Rasmus Kjøbsted, Jonas M. Kristensen, Jesper B. Birk, Nicolas O. Eskesen, Kohei Kido, Nicoline R. Andersen, Jeppe K. Larsen, Marc Foretz, Benoit Viollet, Flemming Nielsen, Kim Brøsen, Niels Jessen, Ylva Hellsten, Kurt Højlund, Jørgen F.P. Wojtaszewski
SummaryMetformin is an inexpensive oral anti-hyperglycemic agent used worldwide as a first-choice drug for the prevention of type 2 diabetes mellitus (T2DM). Although current view suggests that metformin exerts its anti-hyperglycemic effect by loweri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e95a9495b2bdc5f282894c8631445658
https://doi.org/10.1101/2022.05.22.492936
https://doi.org/10.1101/2022.05.22.492936
