Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Killian, Oukoloff"'
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Akademický článek
Inhibition of the HEG1–KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells
Autor: Miguel Alejandro Lopez‐Ramirez, Sara McCurdy, Wenqing Li, Mark K. Haynes, Preston Hale, Karol Francisco, Killian Oukoloff, Matthew Bautista, Chelsea H.J. Choi, Hao Sun, Brendan Gongol, John Y. Shyy, Carlo Ballatore, Larry A. Sklar, Alexandre R. Gingras
Publikováno v: FASEB BioAdvances, Vol 3, Iss 5, Pp 334-355 (2021)
ABSTRACT The transmembrane protein heart of glass1 (HEG1) directly binds to and recruits Krev interaction trapped protein 1 (KRIT1) to endothelial junctions to form the HEG1–KRIT1 protein complex that establishes and maintains junctional integrity.
Externí odkaz: https://doaj.org/article/12d216681c9e4a0d9063a1dd1f6e713e
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2
Akademický článek
A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model
Autor: Bin Zhang, Yuemang Yao, Anne-Sophie Cornec, Killian Oukoloff, Michael J. James, Pyry Koivula, John Q. Trojanowski, Amos B. Smith, Virginia M.-Y. Lee, Carlo Ballatore, Kurt R. Brunden
Publikováno v: Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-15 (2018)
Abstract Background Alzheimer’s disease (AD) and related tauopathies are neurodegenerative diseases that are characterized by the presence of insoluble inclusions of the protein tau within brain neurons and often glia. Tau is normally found associa
Externí odkaz: https://doaj.org/article/7b269cf690304cafbdd47c2d8a1a0c7a
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5
Abstract 6282: EP102: Pharmacological inhibition of METTL3 arrests tumor progression and prolongs survival in CDX and PDX models of AML
Autor: Graeme Fraser, Catherine Sorlet, Nicolas Parmentier, Elodie Brunel, Anne-France Hartiel, Killian Oukoloff, Guillaume Dutheuil
Publikováno v: Cancer Research. 83:6282-6282
METTL3 is the RNA methyltransferase predominantly responsible for the addition of N-6-methyladenosine (m6A), the most abundant modification to mRNA. The prevalence of m6A and the activity and expression of METTL3 have been linked to the appearance an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a17898f1550a0fb5e3ec99c8d9206160
https://doi.org/10.1158/1538-7445.am2023-6282
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6
Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro
Autor: Amos B. Smith, Conor R. Caffrey, Ali Syed, Carlo Ballatore, Kurt R. Brunden, Jane Kovalevich, Ludovica Monti, Lawrence J. Liu, Kristen Prijs, Nelly El-Sakkary, Danielle E. Skinner, Anne-Sophie Cornec, Killian Oukoloff, Thibault Alle
Publikováno v: ACS infectious diseases, vol 7, iss 5
ACS Infect Dis
Schistosomiasis is a parasitic disease that affects approximately 200 million people in developing countries. Current treatment relies on just one partially effective drug and new drugs are needed. Tubulin and microtubules (MTs) are essential constit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c797e9fd5410a3ab9057080b430b07c
https://escholarship.org/uc/item/0jc824t0
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7
Evaluation of the structure-activity relationship of microtubule-targeting 1,2,4-Triazolo[1,5-a]pyrimidines identifies new candidates for neurodegenerative tauopathies
Autor: Jane Kovalevich, Ludovica Monti, Goodwell Nzou, Amos B. Smith, Michael J. James, Bobby Lucero, Anne-Sophie Cornec, Yuemang Yao, Andrea Brancale, Carlo Ballatore, Kurt R. Brunden, Killian Oukoloff, Thibault Alle, Virginia M.-Y. Lee, Carmine Varricchio, John Q. Trojanowski
Publikováno v: J Med Chem
Journal of medicinal chemistry, vol 64, iss 2
Studies in tau and Aβ plaque transgenic mouse models demonstrated that brain-penetrant microtubule (MT)-stabilizing compounds, including the 1,2,4-triazolo[1,5-a]pyrimidines, hold promise as candidate treatments for Alzheimer’s disease (AD) and re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da116b45207527447cdbf555c6648bc
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8
A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model
Autor: John Q. Trojanowski, Virginia M.-Y. Lee, Yuemang Yao, Kurt R. Brunden, Carlo Ballatore, Pyry Koivula, Michael J. James, Amos B. Smith, Killian Oukoloff, Anne-Sophie Cornec, Bin Zhang
Publikováno v: Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-15 (2018)
Molecular Neurodegeneration
Molecular neurodegeneration, vol 13, iss 1
Background Alzheimer’s disease (AD) and related tauopathies are neurodegenerative diseases that are characterized by the presence of insoluble inclusions of the protein tau within brain neurons and often glia. Tau is normally found associated with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a4ec642d121eacc65cb286398365ab
http://link.springer.com/article/10.1186/s13024-018-0291-3
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10
1,2,4-Triazolo[1,5-a]pyrimidines in Drug Design
Autor: Kurt R. Brunden, Carlo Ballatore, Killian Oukoloff, Bobby Lucero, Karol R. Francisco
The 1,2,4-triazolo[1,5-a]pyrimidine (TP) heterocycle, in spite of its relatively simple structure, has proved to be remarkably versatile as evidenced by its use in many different applications reported over the years in different areas of drug design.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25891c570a842da5554a31021a5ed1c8
https://europepmc.org/articles/PMC6394845/
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