Výsledky vyhledávání - "Killer Cells, Natural / immunology"

Expression of NK cell receptor ligands in primary colorectal cancer tissue in relation to the phenotype of circulating NK- and NKT cells, and clinical outcome

Autor: Daniëlle Krijgsman, Wouter Hendrickx, Marianne Hokland, Rob A. E. M. Tollenaar, Davide Bedognetti, Jessica Roelands, Cornelia H.L.A. Wieringa, Morten Andersen, Peter J. K. Kuppen

Publikováno v: Krijgsman, D, Roelands, J, Andersen, M N, Wieringa, C H L A, Tollenaar, R A E M, Hendrickx, W, Bedognetti, D, Hokland, M & Kuppen, P J K 2020, ' Expression of NK cell receptor ligands in primary colorectal cancer tissue in relation to the phenotype of circulating NK-and NKT cells, and clinical outcome ', Molecular Immunology, vol. 128, pp. 205-218 . https://doi.org/10.1016/j.molimm.2020.10.012
Molecular Immunology, 128, 205-218. PERGAMON-ELSEVIER SCIENCE LTD

Introduction Natural killer (NK) cells and natural killer T (NKT) cells are implicated in the development and progression of colorectal cancer (CRC). Tumor cells express NK cell receptor ligands that modulate their function. This study aimed to inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3c413092e22a00923150a44af7ee8b
https://pure.au.dk/portal/da/publications/expression-of-nk-cell-receptor-ligands-in-primary-colorectal-cancer-tissue-in-relation-to-the-phenotype-of-circulating-nk-and-nkt-cells-and-clinical-outcome(c20f24b1-44c6-49c9-a6d0-60172e5cca65).html

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Recovery from COVID-19 in a B-cell-depleted multiple sclerosis patient

Autor: Lars Fugger, Ralf Gold, Kate Attfield, Astrid K. N. Iversen, Hannah Wurm, Aiden Haghikia

Publikováno v: Attfield, K, Iversen, A K, Gold, R, Fugger, L & Haghikia, A 2020, ' Recovery from COVID-19 in a B-cell-depleted multiple sclerosis patient ', Multiple sclerosis (Houndmills, Basingstoke, England), vol. 26, no. 10, pp. 1261-1264 . https://doi.org/10.1177/1352458520943791
Multiple Sclerosis (Houndmills, Basingstoke, England)

Approximately 200,000 multiple sclerosis (MS) patients worldwide receive B-cell-depleting immunotherapy with rituximab (anti-CD20), which eliminates the ability to generate an antibody response to new infections. As severe acute respiratory syndrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d12eb597e93dc5973e5a82e0a59c11
https://ora.ox.ac.uk/objects/uuid:1394a7bc-38fc-4e9a-b856-10f5a22a4f2a

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A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling

Publikováno v: Cell Research

The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An outstanding question is to what extent this heterogeneity is simil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f25bf042b9e65a5256b1f18b046ca0
https://biblio.vub.ac.be/vubir/a-pancancer-blueprint-of-the-heterogeneous-tumor-microenvironment-revealed-by-singlecell-profiling(b9f0fba4-7320-4a10-8710-c4f14ad1b675).html

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Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation

Autor: Alejo, A., Ruiz-Argüello, M. B., Pontejo, S. M., Fernández De Marco, M. D. M., Saraiva, M., Hernáez, B., Alcamí, A.

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositorio de Resultados de Investigación del INIA
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA
INIA: Repositorio de Resultados de Investigación del INIA

The role of cytokines and chemokines in anti-viral defense has been demonstrated, but their relative contribution to protective anti-viral responses in vivo is not fully understood. Cytokine response modifier D (CrmD) is a secreted receptor for TNF a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::41c4c896a7805080dbc72b7e9051afc6
http://link.springer.com/article/10.1038/s41467-018-04098-8

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Mapping and Characterization of HCMV-Specific Unconventional HLA-E-Restricted CD8 T Cell Populations and Associated NK and T Cell Responses Using HLA/Peptide Tetramers and Spectral Flow Cytometry

Autor: Amélie Rousselière, Laurence Delbos, Céline Bressollette, Maïlys Berthaume, Béatrice Charreau

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 263, p 263 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 263
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 23 (1), pp.263. ⟨10.3390/ijms23010263⟩

HCMV drives complex and multiple cellular immune responses, which causes a persistent immune imprint in hosts. This study aimed to achieve both a quantitative determination of the frequency for various anti-HCMV immune cell subsets, including CD8 T,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c251519185848aca94e1699be5c0f0b
https://doi.org/10.3390/ijms23010263

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Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab

Autor: Torben Plesner, René J. P. Musters, Berris van Kessel, Jeroen F. van Velzen, A. Kate Sasser, Pino J. Poddighe, Marloes E.C. Broekmans, Tuna Mutis, Inger S. Nijhof, Henk M. Lokhorst, Jakub Krejcik, Richard W.J. Groen, Kris A. Frerichs, Sonja Zweegman, Niels W.C.J. van de Donk, Andries C. Bloem, Johan van Meerloo, Christopher Chiu

Publikováno v: Krejcik, J, Frerichs, K A, Nijhof, I S, van Kessel, B, van Velzen, J, Bloem, A C, Broekmans, M, Zweegman, S, van Meerloo, J, Musters, R J, Poddighe, P, Groen, R, Chiu, C, Plesner, T, Lokhorst, H M, Sasser, A K, Mutis, T & van de Donk, N W C J 2017, ' Monocytes and granulocytes reduce CD38 expression levels on myeloma cells in patients treated with daratumumab ', Clinical Cancer Research, vol. 23, no. 24, pp. 7498-7511 . https://doi.org/10.1158/1078-0432.CCR-17-2027
Krejcik, J, Frerichs, K A, Nijhof, I S, van Kessel, B, van Velzen, J F, Bloem, A C, Broekmans, M E C, Zweegman, S, van Meerloo, J, Musters, R J P, Poddighe, P J, Groen, R W J, Chiu, C, Plesner, T, Lokhorst, H M, Sasser, A K, Mutis, T & van de Donk, N W C J 2017, ' Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab ', Clinical Cancer Research, vol. 23, no. 24, pp. 7498-7511 . https://doi.org/10.1158/1078-0432.CCR-17-2027
Clinical Cancer Research, 23(24), 7498-7511. American Association for Cancer Research Inc.

Purpose: Daratumumab treatment results in a marked reduction of CD38 expression on multiple myeloma cells. The aim of this study was to investigate the clinical implications and the underlying mechanisms of daratumumab-mediated CD38 reduction. Experi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a411b4972ab21d4db661d3cca064dd68
https://doi.org/10.1158/1078-0432.ccr-17-2027

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NKp46 is a diagnostic biomarker and may be a therapeutic target in gastrointestinal T-cell lymphoproliferative diseases: A CELAC study

Publikováno v: Gut, 68(8), 1396-1405. BMJ Publishing Group
Gut
Gut, BMJ Publishing Group, 2019, 68 (8), pp.1396-1405. ⟨10.1136/gutjnl-2018-317371⟩
Cheminant, M, Bruneau, J, Malamut, G, Sibon, D, Guegan, N, van Gils, T, Cording, S, Trinquand, A, Verkarre, V, Lhermitte, L, Brousse, N, Jannot, A-S, Khater, S, Frenzel, L, Delarue, R, Suarez, F, Marçais, A, Mulder, C J J, Macintyre, E, Asnafi, V, Pouyet, L, Bonnafous, C C, Lhospice, F, Molina, T J, Meresse, B, Cellier, C, Cerf-Bensussan, N & Hermine, O 2019, ' NKp46 is a diagnostic biomarker and may be a therapeutic target in gastrointestinal T-cell lymphoproliferative diseases: A CELAC study ', Gut, vol. 68, no. 8, pp. 1396-1405 . https://doi.org/10.1136/gutjnl-2018-317371
Gut, 2019, 68 (8), pp.1396-1405. ⟨10.1136/gutjnl-2018-317371⟩

ObjectivesPrimary GI T-cell lymphoproliferative diseases (T-LPD) are heterogeneous entities, which raise difficult diagnosis and therapeutic challenges. We have recently provided evidences that lymphomas complicating coeliac disease (CD) arise from i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bf16bc8e37754465b0cd121bf54c22
https://research.vumc.nl/en/publications/c070e3fd-4cc5-486e-8710-e1f8ba369480

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NK cells specifically TCR-dressed to kill cancer cells

Autor: Marit Renée Myhre, Theodossis A. Theodossiou, Pierre Dillard, Gunnar Kvalheim, Nadia Mensali, Else Marit Inderberg, Sébastien Wälchli, June Helen Myklebust, Anne Fåne, Susanne Lorenz, Michael Hebeisen, Gustav Gaudernack

Publikováno v: EBioMedicine
EBioMedicine, vol. 40, pp. 106-117

Background Adoptive T-cell transfer of therapeutic TCR holds great promise to specifically kill cancer cells, but relies on modifying the patient's own T cells ex vivo before injection. The manufacturing of T cells in a tailor-made setting is a long

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd5f8aa4294932b7d12784781053737
http://hdl.handle.net/10852/74614

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Features of Human Decidual NK Cells in Healthy Pregnancy and During Viral Infection

Autor: Jabrane-Ferrat, Nabila

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2019, 10, pp.1397. ⟨10.3389/fimmu.2019.01397⟩
Frontiers in Immunology, 2019, 10, pp.1397. ⟨10.3389/fimmu.2019.01397⟩

International audience; The hallmark of human early pregnancy is the accumulation of a unique population of Natural Killer (dNK) cells at the main maternal-fetal interface, the decidua basalis. dNK cells play a crucial role in successful placentation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5c979fb9d97bbbb520b0d992c71839c1
https://hal.archives-ouvertes.fr/hal-02405520

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