Výsledky vyhledávání - "Killer Cells, Natural/drug effects"

High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment

Autor: Kevin S. Kolahi, Ying-Wen Huang, Ermelinda Porpiglia, Veronica D. Gonzalez, Grace M. Allard, Brooke E. Howitt, Antonio Delgado-Gonzalez, Wendy J. Fantl, Kenyi Donoso, Karen Sachs, Andrew J. Gentles, Shih-Yu Chen

Publikováno v: Gonzalez, V D, Huang, Y-W, Delgado-Gonzalez, A, Chen, S-Y, Donoso, K, Sachs, K, Gentles, A J, Allard, G M, Kolahi, K S, Howitt, B E, Porpiglia, E & Fantl, W J 2021, ' High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment ', Cell Reports, vol. 36, no. 9, pp. 109632 . https://doi.org/10.1016/j.celrep.2021.109632
Cell reports

SUMMARY Tubo-ovarian high-grade serous carcinoma (HGSC) is unresponsive to immune checkpoint blockade despite significant frequencies of exhausted T cells. Here we apply mass cytometry and uncover decidual-like natural killer (dl-NK) cell subpopulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537d63795ab0c91d9205b320248d4a6d
https://pure.au.dk/portal/da/publications/highgrade-serous-ovarian-tumor-cells-modulate-nk-cell-function-to-create-an-immunetolerant-microenvironment(dce086fe-5d07-4afe-8d80-fa0747c8bb6d).html

Zobrazit plný text záznamu

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

Autor: Charlène, Niogret, S M Shahjahan, Miah, Giorgia, Rota, Nicolas P, Fonta, Haiping, Wang, Werner, Held, Walter, Birchmeier, Veronica, Sexl, Wentian, Yang, Eric, Vivier, Ping-Chih, Ho, Laurent, Brossay, Greta, Guarda

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10, ⟨10.1038/s41467-019-09431-3⟩
Nature communications, vol. 10, no. 1, pp. 1444
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 2019, 10, pp.1444. ⟨10.1038/s41467-019-09431-3⟩

The phosphatase Shp-2 was implicated in NK cell development and functions due to its interaction with NK inhibitory receptors, but its exact role in NK cells is still unclear. Here we show, using mice conditionally deficient for Shp-2 in the NK linea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::aab5d0a1358fe400be944c06f1c24b44
https://hal.archives-ouvertes.fr/hal-02359452

Zobrazit plný text záznamu

Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib

Autor: Anton C.M. Martens, Willy A. Noort, Joost M. Bakker, Tuna Mutis, Paul W. H. I. Parren, Berris van Kessel, Inger S. Nijhof, Jeroen J. Lammerts van Bueren, Richard W.J. Groen, Regina de Jong-Korlaar, Niels W.C.J. van de Donk, Henk M. Lokhorst

Publikováno v: Clinical Cancer Research, 21(12), 2802-2810. American Association for Cancer Research Inc.
Nijhof, I S, Groen, R W J, Noort, W A, van Kessel, B, de Jong-Korlaar, R, Bakker, J, van Bueren, J J L, Parren, P W H I, Lokhorst, H M, van de Donk, N W C J, Martens, A C M & Mutis, T 2015, ' Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib ', Clinical Cancer Research, vol. 21, no. 12, pp. 2802-2810 . https://doi.org/10.1158/1078-0432.CCR-14-1813
Nijhof, I S, Groen, R W J, Noort, W A, van Kessel, B, de Jong-Korlaar, R, Bakker, J, van Bueren, J J L, Parren, P W H I, Lokhorst, H M, van de Donk, N, Martens, A C M & Mutis, T 2015, ' Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib ', Clinical Cancer Research, vol. 21, no. 12, pp. 2802-2810 . https://doi.org/10.1158/1078-0432.CCR-14-1813

Purpose: Novel therapeutic agents have significantly improved the survival of patients with multiple myeloma. Nonetheless, the prognosis of patients with multiple myeloma who become refractory to the novel agents lenalidomide and bortezomib is very p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc002482a8f6d680034431f465f4cc8
https://doi.org/10.1158/1078-0432.ccr-14-1813

Zobrazit plný text záznamu

Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy

Autor: Martino Introna, Paul W. H. I. Parren, Fabio Da Roit, Alessandro Rambaldi, Ronald P. Taylor, Giuseppe Gritti, Josée Golay, Frank J. Beurskens, Esther C.W. Breij, Patrick J. Engelberts

Publikováno v: Da Roit, F, Engelberts, P J, Taylor, R P, Breij, E C, Gritti, G, Rambaldi, A, Introna, M, Parren, P W, Beurskens, F J & Golay, J 2015, ' Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy ', Haematologica, vol. 100, no. 1, pp. 77-86 . https://doi.org/10.3324/haematol.2014.107011

The novel Bruton tyrosine kinase inhibitor ibrutinib and phosphatidyl-4-5-biphosphate 3-kinase-δ inhibitor idelalisib are promising drugs for the treatment of chronic lymphocytic leukemia and B-cell non-Hodgkin lymphoma, either alone or in combinati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb00af48e71c6ed89103d123792d3918
https://doi.org/10.3324/haematol.2014.107011

Zobrazit plný text záznamu

A prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: a multicentre, retrospective analysis

Publikováno v: Kim, S J, Yoon, D H, Jaccard, A, Chng, W J, Lim, S T, Hong, H, Park, Y, Chang, K M, Maeda, Y, Ishida, F, Shin, D-Y, Kim, J S, Jeong, S H, Yang, D-H, Jo, J-C, Lee, G-W, Choi, C W, Lee, W-S, Chen, T-Y, Kim, K, Jung, S-H, Murayama, T, Oki, Y, Advani, R, d'Amore, F, Schmitz, N, Suh, C, Suzuki, R, Kwong, Y L, Lin, T-Y & Kim, W S 2016, ' A prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment : a multicentre, retrospective analysis ', Lancet Oncology, vol. 17, no. 3, pp. 389-400 . https://doi.org/10.1016/S1470-2045(15)00533-1

BACKGROUND: The clinical outcome of extranodal natural killer T-cell lymphoma (ENKTL) has improved substantially as a result of new treatment strategies with non-anthracycline-based chemotherapies and upfront use of concurrent chemoradiotherapy or ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f83e0f8e7adde0afe356996b5df7900
https://pubmed.ncbi.nlm.nih.gov/26873566

Zobrazit plný text záznamu

PRDM1 is a tumor suppressor gene in natural killer cell malignancies

Autor: Wing C. Chan, Timothy W. McKeithan, Javeed Iqbal, Phillip Gaulard, Laurence de Leval, Wing Y. Au, Can Küçük, Gopesh Srivastava, Xiaozhou Hu

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (50), pp.20119-24. ⟨10.1073/pnas.1115128108⟩
Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 50, pp. 20119-20124

Natural killer cell lymphoma (NKCL) constitutes a rare and aggressive form of non-Hodgkin lymphoma, and there is little insight into its pathogenesis. Here we show that PRDM1 is a tumor suppressor gene in NKCLs that is inactivated by a combination of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd576552b295a146ea5212abd8eb9ab7
https://doi.org/10.1073/pnas.1115128108

Zobrazit plný text záznamu

Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid

Autor: Toliopoulos, I. K., Yannis Simos, Daskalou, T. A., Verginadis, I. I., Evangelou, A. M., Karkabounas, S. C.

Publikováno v: Scopus-Elsevier

Platelets aggregation around migrating tumor cells offers protection against the cytotoxic activity of the natural killers cells (NKC). The ascorbic acid in 3 x 10(-3) M concentration completely inhibited platelet aggregation, decreased thromboxane B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5d1b5184564ba9e3392b1137d7466937
http://olympias.lib.uoi.gr/jspui/handle/123456789/20750

Zobrazit plný text záznamu

TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA

Autor: Laurent Gauthier, Nathalie Bonnefoy-Berard, Mathieu Blery, Yannis Morel, Isabelle Durand, Ivan Perrot, Christophe Caux, Pierre Garrone, Lena Alexopoulou, Florence Deauvieau, Catherine Massacrier, Giorgio Trinchieri, Nicola Hughes, Nicolas Viaud, Jürg Tschopp, Carine Paturel, Olivier Demaria

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 185 (4), pp.2080-8. ⟨10.4049/jimmunol.1000532⟩
Journal of Immunology, 2010, 185 (4), pp.2080-8. ⟨10.4049/jimmunol.1000532⟩
Journal of Immunology, vol. 185, no. 4, pp. 2080-2088

Cross-talk between NK cells and dendritic cells (DCs) is critical for the potent therapeutic response to dsRNA, but the receptors involved remained controversial. We show in this paper that two dsRNAs, polyadenylic-polyuridylic acid and polyinosinic-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec534d69a148c97a95aff2c4a063369
https://hal.archives-ouvertes.fr/hal-00553598

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání