Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Kilian V M, Huber"'
Autor:
Xuemin Chen, McKenna C. Crawford, Ying Xiong, Anver Basha Shaik, Kiall F. Suazo, Ludwig G. Bauer, Manini S. Penikalapati, Joycelyn H. Williams, Kilian V. M. Huber, Thorkell Andressen, Rolf E. Swenson, Jordan L. Meier
Publikováno v:
JACS Au, Vol 4, Iss 8, Pp 3094-3103 (2024)
Externí odkaz:
https://doaj.org/article/78fefbd568c44de996e8b61d29912560
Autor:
Daniela Digles, Alvaro Ingles-Prieto, Vojtech Dvorak, Tamara A. M. Mocking, Ulrich Goldmann, Andrea Garofoli, Evert J. Homan, Alberto Di Silvio, Lucia Azzollini, Francesca Sassone, Mario Fogazza, Felix Bärenz, Antje Pommereau, Yasmin Zuschlag, Jasper F. Ooms, Jeppe Tranberg-Jensen, Jesper S. Hansen, Josefina Stanka, Hubert J. Sijben, Helena Batoulis, Eckhard Bender, Riccardo Martini, Adriaan P. IJzerman, David B. Sauer, Laura H. Heitman, Vania Manolova, Juergen Reinhardt, Alexander Ehrmann, Philipp Leippe, Gerhard F. Ecker, Kilian V. M. Huber, Thomas Licher, Lia Scarabottolo, Tabea Wiedmer, Giulio Superti-Furga
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with a wide variety of human diseases, inc
Externí odkaz:
https://doaj.org/article/d3ca8f18dbc2476ea3722a966b570ca6
Autor:
Carrow I. Wells, James D. Vasta, Cesear R. Corona, Jennifer Wilkinson, Chad A. Zimprich, Morgan R. Ingold, Julie E. Pickett, David H. Drewry, Kathryn M. Pugh, Marie K. Schwinn, Byounghoon (Brian) Hwang, Hicham Zegzouti, Kilian V. M. Huber, Mei Cong, Poncho L. Meisenheimer, Timothy M. Willson, Matthew B. Robers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs. Here, the authors report the development of a panel of fluorescent reporter probe
Externí odkaz:
https://doaj.org/article/5ab2cf72cb7f4b5ea0a65e02f4e02daf
Autor:
Sebastian Scheer, Suzanne Ackloo, Tiago S. Medina, Matthieu Schapira, Fengling Li, Jennifer A. Ward, Andrew M. Lewis, Jeffrey P. Northrop, Paul L. Richardson, H. Ümit Kaniskan, Yudao Shen, Jing Liu, David Smil, David McLeod, Carlos A. Zepeda-Velazquez, Minkui Luo, Jian Jin, Dalia Barsyte-Lovejoy, Kilian V. M. Huber, Daniel D. De Carvalho, Masoud Vedadi, Colby Zaph, Peter J. Brown, Cheryl H. Arrowsmith
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Protein methyltransferases (PMTs) are epigenetic regulatory enzymes with significant therapeutic relevance. Here the authors describe a collection of chemical inhibitors and antagonists to modulate most of the key methylation marks on histones H3 and
Externí odkaz:
https://doaj.org/article/b9017f82fb1d46769b1e67347ec72d39
Publikováno v:
Expert Opinion on Drug Discovery. 18:505-513
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8a0e749c7bcf4bd4c5998248e6008aa
https://doi.org/10.1080/17460441.2023.2199979
https://doi.org/10.1080/17460441.2023.2199979
Autor:
Branka Radic-Sarikas, Melinda Halasz, Kilian V. M. Huber, Georg E. Winter, Kalliopi P. Tsafou, Theodore Papamarkou, Søren Brunak, Walter Kolch, Giulio Superti-Furga
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Adverse side effects of cancer agents are of great concern in the context of childhood tumors where they can reduce the quality of life in young patients and cause life-long adverse effects. Synergistic drug combinations can lessen potential
Externí odkaz:
https://doaj.org/article/69692b39268b4938b59ac45022e3640d
Autor:
Giulio Superti-Furga, Heinrich Kovar, Søren Brunak, Jesper V. Olsen, Keiryn L. Bennett, Jeffrey A. Toretsky, Cornelia Mutz, Kilian V. M. Huber, Theodore Papamarkou, Kristina B. Emdal, Kalliopi P. Tsafou, Branka Radic-Sarikas
Distribution of strong and very strong synergy across the three screens (appendix to Figure 1B and Figure 2A).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355ffe883e967b842d95e47785e1755a
https://doi.org/10.1158/1535-7163.22508544.v1
https://doi.org/10.1158/1535-7163.22508544.v1
Autor:
Paola Martinelli, Otmar Schaaf, Andreas Mantoulidis, Laetitia J. Martin, Julian E. Fuchs, Gerd Bader, Andreas Gollner, Bernhard Wolkerstorfer, Catherine Rogers, Esra Balıkçı, Jesse J. Lipp, Nikolai Mischerikow, Sandra Doebel, Thomas Gerstberger, Wolfgang Sommergruber, Kilian V. M. Huber, Jark Böttcher
Publikováno v:
ChemMedChem. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06d1b74e691f2507bc3544e1dd6c012e
https://doi.org/10.1002/cmdc.202200686
https://doi.org/10.1002/cmdc.202200686
Autor:
Elisabeth M. Rothweiler, Jakub Stefaniak, Jennifer A. Ward, Catherine Rogers, Esra Balikci, Kilian V. M. Huber
Increasing evidence suggests the protein arginine methyltransferase PRMT5 as a contributor to tumorigenesis in various cancer types and several inhibitors have entered clinical trials. Robust assays to determine cellular target engagement and selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e56a36b2c98f90c8ab8b40d0cb8d4a3
https://doi.org/10.1101/2022.01.20.477145
https://doi.org/10.1101/2022.01.20.477145
Autor:
Moses Moustakim, Peter G. K. Clark, Laura Trulli, Angel L. Fuentes de Arriba, Matthias T. Ehebauer, Apirat Chaikuad, Emma J. Murphy, Jacqui Mendez‐Johnson, Danette Daniels, Chun‐Feng D. Hou, Yu‐Hui Lin, John R. Walker, Raymond Hui, Hongbing Yang, Lucy Dorrell, Catherine M. Rogers, Octovia P. Monteiro, Oleg Fedorov, Kilian V. M. Huber, Stefan Knapp, Jag Heer, Darren J. Dixon, Paul E. Brennan
Publikováno v:
Angewandte Chemie (International Ed. in English)
The p300/CBP‐associated factor (PCAF) and related GCN5 bromodomain‐containing lysine acetyl transferases are members of subfamily I of the bromodomain phylogenetic tree. Iterative cycles of rational inhibitor design and biophysical characterizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57074ca926db2ff6a6e9f600c7cae6c
http://publikationen.ub.uni-frankfurt.de/files/47700/Moustakim_et_al-2017-Angewandte_Chemie_International_Edition.pdf
http://publikationen.ub.uni-frankfurt.de/files/47700/Moustakim_et_al-2017-Angewandte_Chemie_International_Edition.pdf