Výsledky vyhledávání - "Kiley R. Prilliman"

Population of the HLA Ligand Database

Autor: Heather D. Hickman, William H. Hildebrand, S. Metcalf, Joshua W. Cavett, M. A. Fernandez Vina, Muthuraman Sathiamurthy, Kiley R. Prilliman, A. Zahoor

Publikováno v: Tissue Antigens. 61:12-19

We have established an HLA ligand database to provide scientists and clinicians with access to Major Histocompatibility Complex (MHC) class I and II motif and ligand data. The HLA Ligand Database is available on the world wide web at http://hlaligand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e1bf5349a53e07c4392805a576ccd57
https://doi.org/10.1034/j.1399-0039.2003.610102.x

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CD40L Blockade Prevents Autoimmune Diabetes by Induction of Bitypic NK/DC Regulatory Cells

Autor: Tom Wolfe, Kiley R. Prilliman, Angelika Jahreis, Matthias von Herrath, Marianne J. B. van Stipdonk, Bryan Coon, Anna Hughes, Stephen P. Schoenberger, Dirk Homann

Publikováno v: Immunity. 16(3):403-415

Systemic treatment with antibody to CD40 ligand (aCD40L) can prevent autoimmunity and transplant rejection in several animal models and is currently under evaluation in clinical trials. While it is known that aCD40L administration inhibits expansion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16822eaaec67c28ea2eb5ebb5b91fb31

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Gorillas with Spondyloarthropathies Express an MHC Class I Molecule with Only Limited Sequence Similarity to HLA-B27 that Binds Peptides with Arginine at P2

Autor: Bonnie L. Raphael, Clare Shufflebotham, Kevin J. Schwartz, David I. Watkins, William H. Hildebrand, Donald L. Neiffer, Heather D. Hickman, Edward J. Collins, David Lorentzen, Kiley R. Prilliman, John L. Dzuris, Julie A. Urvater, Alessandro Sette, Todd M. Allen

Publikováno v: The Journal of Immunology. 166:3334-3344

The human MHC class I gene, HLA-B27, is a strong risk factor for susceptibility to a group of disorders termed spondyloarthropathies (SpAs). HLA-B27-transgenic rodents develop SpAs, implicating HLA-B27 in the etiology of these disorders. Several nonh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e251725efa0613881cfc6c07a02e6b30
https://doi.org/10.4049/jimmunol.166.5.3334

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C-terminal epitope tagging facilitates comparative ligand mapping from MHC class I positive cells

Autor: Kiley R. Prilliman, David Crawford, Heather D. Hickman, William H. Hildebrand, Kenneth L Jackson, Casey L Batson

Publikováno v: Human Immunology. 61:1339-1346

Purification of specific class I molecules prior to peptide ligand characterization is complicated by the presence of multiple class I proteins in most cell lines. Immortalized B, T, and tumor cell lines typically express endogenous HLA-A, -B, and -C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611e2bf970c64d2a40b296eb937a7f53
https://doi.org/10.1016/s0198-8859(00)00216-0

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HLA-B polymorphism affects interactions with multiple endoplasmic reticulum proteins

Autor: Joyce C. Solheim, William H. Hildebrand, Kiley R. Prilliman, Heth R. Turnquist, Heather J. Thomas, Charles T. Lutz

Publikováno v: European Journal of Immunology. 30:3021-3028

To explore the nature of amino acid substitutions that influence association with TAP, we compared a site-directed mutant of HLA-B*0702 (Y116D) to unmutated HLA-B7 in regard to TAP interaction. We found that the mutant had stronger association with T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e30bc853d66bbdd3be6909b98a4edf70
https://doi.org/10.1002/1521-4141(200010)30:10<3021::aid-immu3021>3.0.co

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Alpha-2 domain polymorphism and HLA class I peptide loading

Autor: William H. Hildebrand, Kiley R. Prilliman, Kenneth W. Jackson, David Crawford, Heather D. Hickman, Jihua Wang

Publikováno v: Tissue Antigens. 54:450-460

Diversity within the class I HLA antigen binding groove is positioned to moderate the presentation of peptide ligands. Polymorphism is widely dispersed about the peptide binding groove, and unravelling the functional significance of a given polymorph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17125abd5aa1106c3854f4ff47800073
https://doi.org/10.1034/j.1399-0039.1999.540502.x

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HLA-B15 Peptide Ligands Are Preferentially Anchored at Their C Termini

Autor: Kiley R. Prilliman, Kenneth W. Jackson, Mark Lindsey, Jihua Wang, David Crawford, William H. Hildebrand

Publikováno v: The Journal of Immunology. 162:7277-7284

Therapies to elicit protective CTL require the selection of pathogen- and tumor-derived peptide ligands for presentation by MHC class I molecules. Edman sequencing of class I peptide pools generates “motifs” that indicate that nonameric ligands b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a94ceece9aeaf30205751ad9740979ac
https://doi.org/10.4049/jimmunol.162.12.7277

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Complexity among constituents of the HLA-B*1501 peptide motif

Autor: Kenneth W. Jackson, Kiley R. Prilliman, Jeffrey Cole, William H. Hildebrand, Ron Bonner, Mark Lindsey

Publikováno v: Immunogenetics. 48:89-97

Analysis of peptides derived from HLA class I molecules indicates that thousands of unique peptides are bound by a single molecular type, and sequence examination of the pooled constituents yields a motif which collectively defines the peptides bound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcca7fc9bff261d410fb700f0324964
https://doi.org/10.1007/s002510050408

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