Transport of Kynurenic Acid by Rat Organic Anion Transporters rOAT1 and rOAT3: Species Difference between Human and Rat in OAT1

Autor: Hiroaki Hara, Yuichi Uwai, Kikuo Iwamoto

Publikováno v: International Journal of Tryptophan Research, Vol 2013, Iss 6, Pp 1-6 (2013)
International Journal of Tryptophan Research : IJTR
International Journal of Tryptophan Research, Vol 6 (2013)

A tryptophan catabolite, kynurenic acid, is involved in schizophrenia and uremia; there is little information on the mechanism of its disposition. Recently, our laboratory showed that kynurenic acid is a good substrate of human organic anion transpor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fd76ac16110b702fc25197a815c9e4
http://la-press.com/transport-of-kynurenic-acid-by-rat-organic-anion-transporters-roat1-an-article-a3542

Inhibitory Effect of Caffeic Acid on Human Organic Anion Transporters hOAT1 and hOAT3: A Novel Candidate for Food–Drug Interaction

Autor: Kikuo Iwamoto, Yuichi Uwai, Tomonori Isaka, Yukihiro Ozeki, Hiroaki Honjo

Publikováno v: Drug Metabolism and Pharmacokinetics. 26:486-493

Several kinds of food have been shown to influence the absorption and metabolism of drugs, although there is little information about their effect on the renal excretion of drugs. In this study, we performed uptake experiments using Xenopus laevis oo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caff928a7e7923b2bf175d6c82b3fff3
https://doi.org/10.2133/dmpk.dmpk-11-rg-020

[Untitled]

Autor: Noriyuki ISHIHARA, Nobuhiro NISHIMURA, Takayuki SUYAMA, Akira YAMAMOTO, Hiroki TAMAKI, Tomochika UEMURA, Takeshi ISOBE, Fumiko INAGAKI, Kikuo IWAMOTO, Kohji NAORA

Publikováno v: Japanese Journal of Environmental Infections. 25:15-21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d40cf90c9780980c1929275f5e83c2d9
https://doi.org/10.4058/jsei.25.15

Pharmaceutical Analysis and Clinical Efficacy of Kampo Medicine, Maoto, Extract Suppository Against Pediatric Febrile Symptoms

Autor: Takeshi Taketani, Nobuhiro Nishimura, Kohji Naora, Takeshi Kasai, Seiji Yamaguchi, Rie Kanai, George Hayashi, Tomochika Uemura, Norio Doi, Kikuo Iwamoto

Publikováno v: YAKUGAKU ZASSHI. 129:759-766

A traditional Chinese herbal medicine, Kampo medicine, maoto, has been widely used in the treatment of febrile symptoms caused by viral infection. This herbal extract granule for oral use, however, is not well accepted by infants or young children du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d4d97df1ffcac627bfe304f61cae6f
https://doi.org/10.1248/yakushi.129.759

Comparative Study on Salivary Distribution of Fluoroquinolones in Rats

Autor: Hideki Okunishi, Hidenari Hirano, Kohji Naora, Qiuhong Li, Kikuo Iwamoto

Publikováno v: Biological and Pharmaceutical Bulletin. 25:1084-1089

As a basic approach to identifying the distribution mechanism of quinolone antibiotics into saliva, salivary excretion of five fluoroquinolones, ciprofloxacin (CPFX), norfloxacin (NFLX), lomefloxacin (LFLX), ofloxacin (OFLX) and sparfloxacin (SPFX),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e84f714df2a417e87dfa703ef50df73
https://doi.org/10.1248/bpb.25.1084