Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kikuko Amo"'
Autor:
Syota Kagawa, Katsuya Tanabe, Makoto Hiromura, Kakuyou Ogawa, Takayuki Koga, Takahiro Maeda, Kikuko Amo-Shiinoki, Hiroyuki Ochi, Yui Ichiki, Shogo Fukuyama, Saori Suzuki, Natsuki Suizu, Takaaki Ohmine, Sakurako Hamachi, Hiroshi Tsuneki, Shigeru Okuya, Toshiyasu Sasaoka, Yukio Tanizawa, Fumihiro Nagashima
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Hachimijiogan (HJG) has originally been used to ameliorate a variety of symptoms associated with low ambient temperatures. However, its pharmacological action in metabolic organs remains unclear. We hypothesized that HJG may modulate metabolic functi
Externí odkaz:
https://doaj.org/article/6a843b8816024421a6964c11f6afff37
Autor:
Kikuko Amo-Shiinoki, Katsuya Tanabe, Yoshinobu Hoshii, Hiroto Matsui, Risa Harano, Tatsuya Fukuda, Takato Takeuchi, Ryotaro Bouchi, Tokiyo Takagi, Masayuki Hatanaka, Komei Takeda, Shigeru Okuya, Wataru Nishimura, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe, Takumi Akashi, Tetsuya Yamada, Yoshihiro Ogawa, Eiji Ikeda, Hiroaki Nagano, Yukio Tanizawa
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
Dedifferentiation has been implicated in β cell dysfunction and loss in rodent diabetes. However, the pathophysiological significance in humans remains unclear. To elucidate this, we analyzed surgically resected pancreatic tissues of 26 Japanese sub
Externí odkaz:
https://doaj.org/article/92a308a1444447e78710fef4553a9fd9
Publikováno v:
Journal of Diabetes Research, Vol 2017 (2017)
Type 2 diabetes mellitus (T2DM) results from pancreatic β-cell failure in the setting of insulin resistance. In the early stages of this disease, pancreatic β-cells meet increased insulin demand by both enhancing insulin-secretory capacity and incr
Externí odkaz:
https://doaj.org/article/dc5af6378e0e402b9267513e287d177c
Autor:
Takashi Uebanso, Yutaka Taketani, Hironori Yamamoto, Kikuko Amo, Hirokazu Ominami, Hidekazu Arai, Yuichiro Takei, Masashi Masuda, Ayako Tanimura, Nagakatsu Harada, Hisami Yamanaka-Okumura, Eiji Takeda
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22976 (2011)
Fibroblast growth factor 21 (FGF21) has recently emerged as a metabolic hormone involved in regulating glucose and lipid metabolism in mouse, but the regulatory mechanisms and actions of FGF21 in humans remain unclear. Here we have investigated the r
Externí odkaz:
https://doaj.org/article/c74175d39e004a25a8edb88e4752d59e
Autor:
Yuko Nagao, Kikuko Amo-Shiinoki, Hiroko Nakabayashi, Masayuki Hatanaka, Manabu Kondo, Kimie Matsunaga, Masahiro Emoto, Shigeru Okuya, Yukio Tanizawa, Katsuya Tanabe
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13586
Endoplasmic reticulum (ER) stress is a key pathogenic factor in type 1 and 2 diabetes. Glycogen synthase kinase 3 (Gsk-3) contributes to β-cell loss in mice. However, the mechanism by which Gsk-3 leads β-cell death remains unclear. ER stress was ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3404e538dd711ed0b9f7d6731d55571d
https://doi.org/10.3390/ijms232113586
https://doi.org/10.3390/ijms232113586
Autor:
Tetsuya Yamada, Tatsuya Fukuda, Yoshinobu Hoshii, Ryotaro Bouchi, Takato Takeuchi, Yukio Tanizawa, Shigeru Okuya, Shinji Tanaka, Hiroaki Nagano, Tokiyo Takagi, Katsuya Tanabe, Takumi Akashi, Masayuki Hatanaka, Komei Takeda, Yoshihiro Ogawa, Kikuko Amo-Shiinoki, Wataru Nishimura, Minoru Tanabe, Eiji Ikeda, Risa Harano, Hiroto Matsui, Atsushi Kudo
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
JCI Insight
JCI Insight
Dedifferentiation has been implicated in β cell dysfunction and loss in rodent diabetes. However, the pathophysiological significance in humans remains unclear. To elucidate this, we analyzed surgically resected pancreatic tissues of 26 Japanese sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fdf0e3ffc2c8bd43f297fece40f71c
https://doaj.org/article/92a308a1444447e78710fef4553a9fd9
https://doaj.org/article/92a308a1444447e78710fef4553a9fd9
Autor:
Takato Takeuchi, Katsuya Tanabe, Kikuko Amo-Shiinoki, Tetsuya Yamada, Ryotaro Bouchi, Tatsuya Fukuda, Yoshihiro Ogawa, Yukio Tanizawa
Publikováno v:
Diabetes. 69
To elucidate the pathogenesis of post-pancreatectomy diabetes (PPDM), we carried out a prospective observational study in patients without diabetes undergoing partial pancreatectomy, investigating the effects of gut microbiota, incretins, and short-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4f46328af511d56992806dbd050e311
https://doi.org/10.2337/db20-231-lb
https://doi.org/10.2337/db20-231-lb
Autor:
Yoshihiro Ogawa, Yukio Tanizawa, Kikuko Amo-Shiinoki, Wataru Nishimura, Katsuya Tanabe, Ryotaro Bouchi
Publikováno v:
Diabetes. 69
T2D is associated with deficits of β-cell function and number. But it remains unclear how these processes interact during disease progression. It has been described that islet cell plasticity, i.e., β-cell dedifferentiation and conversion into othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::852c77e6af3e6b011721150797058bce
https://doi.org/10.2337/db20-2037-p
https://doi.org/10.2337/db20-2037-p
Autor:
Shinji Tanaka, Katsuya Tanabe, Miki Igarashi, Atsushi Kudo, Yukio Tanizawa, Yoshihiro Ogawa, Takato Takeuchi, Minoru Tanabe, Toshitaka Odamaki, Kazuhiro Hirayama, Ikuo Kimura, Takumi Akashi, Ryotaro Bouchi, Tetsuya Yamada, Tatsuya Fukuda, Kikuko Amo-Shiinoki
Publikováno v:
Diabetes care. 44(4)
OBJECTIVE To elucidate the pathogenesis of postpancreatectomy diabetes mellitus (PPDM). RESEARCH DESIGN AND METHODS Forty-eight patients without diabetes undergoing either pancreatoduodenectomy (PD) (n = 20) or distal pancreatectomy (DP) (n = 28) wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbbc4171d25663eaad81eb3cf9b2de9
https://pubmed.ncbi.nlm.nih.gov/33627367
https://pubmed.ncbi.nlm.nih.gov/33627367
Publikováno v:
Diabetes. 68
Loss of functional β cells results in a gradual progression of insulin insufficiency in Wolfram syndrome caused by recessive WFS1 mutations. Currently, there are no specific treatment recommendations for the disease. We have so far evidenced that, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e27694e6a0730a4a3d519f954b07af1b
https://doi.org/10.2337/db19-323-lb
https://doi.org/10.2337/db19-323-lb