Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Kikuko, Amagase"'
Autor:
Ayana Fujiwara, Keisuke Takemura, Anna Tanaka, Misaki Matsumoto, Masato Katsuyama, Takeshi Okanoue, Kanji Yamaguchi, Yoshito Itoh, Kazumi Iwata, Kikuko Amagase, Atsushi Umemura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Because hepatic stellate cells (HSCs) play a major role in fibrosis, we focused on HSCs as a potential target for the treatment of liver fibrosis. In this study, we attempted to identify drug candidates to inactivate HSCs and found that seve
Externí odkaz:
https://doaj.org/article/b3a0293e746b4e4aa4f6b1fa1200d07d
Autor:
Mounir A. A. Mohamed, Asmaa M. Kadry, Salma A. Bekhit, Mohammed A. S. Abourehab, Kikuko Amagase, Tamer M. Ibrahim, Ahmed M. M. El-Saghier, Adnan A. Bekhit
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 330-342 (2023)
New spiro-piperidine derivatives were synthesised via the eco-friendly ionic liquids in a one-pot fashion. The in vitro antileishmanial activity against Leishmania major promastigote and amastigote forms highlighted promising antileishmanial activity
Externí odkaz:
https://doaj.org/article/3361f7177b13486f9524e0a4b7c66cd9
Autor:
Shota Okamoto, Makoto Yasuda, Kotoku Kawaguchi, Kasane Yasuoka, Yumi Kikukawa, Shinji Asano, Taisei Tsujii, Sana Inoue, Kikuko Amagase, Taka-aki Inui, Shigeru Hirano, Toshio Inui, Yoshinori Marunaka, Takashi Nakahari
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 9069 (2024)
An application of CO2/HCO3−-free solution (Zero-CO2) did not increase intracellular pH (pHi) in ciliated human nasal epithelial cells (c-hNECs), leading to no increase in frequency (CBF) or amplitude (CBA) of the ciliary beating. This study demonst
Externí odkaz:
https://doaj.org/article/9300c44f711544318710514fbd37be99
Autor:
Adnan A. Bekhit, Eskedar T. Lodebo, Ariaya Hymete, Hanan M. Ragab, Salma A. Bekhit, Kikuko Amagase, Afnan Batubara, Mohammed A. S. Abourehab, Alaa El-Din A. Bekhit, Tamer M. Ibrahim
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2320-2333 (2022)
Promising inhibitory activities of the parasite multiplication were obtained upon evaluation of in vivo antimalarial activities of new pyrazolylpyrazoline derivatives against Plasmodium berghei infected mice. Further evaluation of 5b and 6a against c
Externí odkaz:
https://doaj.org/article/c2480f42d54a4089bc0c1c71eabf297c
Publikováno v:
Интегративная физиология, Vol 3, Iss 4 (2022)
Glutamine, the most abundant free amino acid in the human body, is a major molecule utilized by intestinal cells. It has been reported that glutamine is involved in intestinal physiology and management of multiple intestinal diseases. In gut physiolo
Externí odkaz:
https://doaj.org/article/f36172e81d60409bbee4cd582b650a20
Publikováno v:
Интегративная физиология, Vol 3, Iss 3 (2022)
5-fluorouracil (5-FU), which is widely used as an anticancer drug, causes enteritis due to disruption of mucosal tissue, resulting in diarrhoea and body weight loss. Ginsenoside Rd (GRd) and ginsenoside Re (GRe) are two of the saponins contained in c
Externí odkaz:
https://doaj.org/article/cb5106cbf4574b4bad8cc27bb622bd4b
Publikováno v:
Интегративная физиология, Vol 1, Iss 2 (2020)
We examined the stimulatory effects of lubiprostone, a bicyclic fatty acid derived from prostaglandin E1 and a chloride channel type-2 opener (ClC-2), on HCO3- secretion in the rat stomach and duodenum, with a focus on the EP receptor subtypes involv
Externí odkaz:
https://doaj.org/article/fa848bdb93c24c32a22c198a82ed971e
Autor:
Daichi Utsumi, Kenjiro Matsumoto, Takuya Tsukahara, Kikuko Amagase, Makoto Tominaga, Shinichi Kato
Publikováno v:
Journal of Pharmacological Sciences, Vol 136, Iss 3, Pp 121-132 (2018)
Transient receptor potential (TRP) vanilloid 1 (TRPV1) and TRP ankyrin 1 (TRPA1), which are non-selective cation channels, play important roles in the sensation of pain. This study investigated the roles of TRPV1 and TRPA1 in dextran sulfate sodium (
Externí odkaz:
https://doaj.org/article/719dfcb29c6942e2b90239cbf230958b
Publikováno v:
Physiology. 38
Background & Aim: 5-fluorouracil (5-FU), a type of anticancer drug, induces enteritis with diarrhea in high frequency and significantly reduces the quality of life of patients. Though inhibition of cell growth, induction of apoptosis, and changes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4c6d67e8ce5dd95cd37b161c42a8ffa
https://doi.org/10.1152/physiol.2023.38.s1.5735213
https://doi.org/10.1152/physiol.2023.38.s1.5735213
Publikováno v:
Physiology. 38
Background & Aim: It has been reported that 5-fluorouracil (5-FU), a widely used anticancer drug, causes intestinal inflammation due to shortening of small intestinal villi and destruction of the glandular fossa, resulting in diarrhea and weight loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddfe247dc36864c6a220801fa12c72ce
https://doi.org/10.1152/physiol.2023.38.s1.5734772
https://doi.org/10.1152/physiol.2023.38.s1.5734772