Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Kikuchi, Macoto"'
Autor:
Kikuchi, Macoto
Publikováno v:
PLoS ONE 19 (2024): e0311058
The mutation-selection mechanism of Darwinian evolution gives rise not only to adaptation to environmental conditions but also to the enhancement of robustness against mutations. When two or more phenotypes have the same fitness value, the robustness
Externí odkaz:
http://arxiv.org/abs/2310.15729
Autor:
Kikuchi, Macoto1 (AUTHOR) kikuchi.macoto.cmc@osaka-u.ac.jp
Publikováno v:
PLoS ONE. 11/18/2024, Vol. 19 Issue 11, p1-16. 16p.
Autor:
Kaneko, Tadamune, Kikuchi, Macoto
Publikováno v:
PLoS Comput Biol 18 (2022) e1009796
The aim of this paper is two-fold. First, we propose a new computational method to investigate the particularities of evolution. Second, we apply this method to a model of gene regulatory networks (GRNs) and explore the evolution of mutational robust
Externí odkaz:
http://arxiv.org/abs/2012.03030
Autor:
Nagata, Shintaro, Kikuchi, Macoto
Publikováno v:
PLoS Comput Biol 16(6): e1007969 (2020)
Gene regulatory networks (GRNs) are complex systems in which many genes regulate mutually to adapt the cell state to environmental conditions. In addition to function, the GRNs possess several kinds of robustness. This robustness means that systems d
Externí odkaz:
http://arxiv.org/abs/1907.12030
Autor:
Shirai, Nobu C., Kikuchi, Macoto
Publikováno v:
J. Chem. Phys. 144, 055101 (2016)
{\alpha}-synuclein ({\alpha}-syn) is an intrinsically disordered protein which is considered to be one of the causes of Parkinson's disease. This protein forms amyloid fibrils when in a highly concentrated solution. The fibril formation of {\alpha}-s
Externí odkaz:
http://arxiv.org/abs/1411.3383
Autor:
Shirai, Nobu C., Kikuchi, Macoto
Publikováno v:
J. Chem. Phys. 139, 225103 (2013)
An intrinsically disordered protein (IDP) lacks a stable three-dimensional structure, while it folds into a specific structure when it binds to a target molecule. In some IDP-target complexes, not all target binding surfaces are exposed on the outsid
Externí odkaz:
http://arxiv.org/abs/1310.0889
Autor:
Shirai, Nobu C., Kikuchi, Macoto
Publikováno v:
Interdisciplinary Information Sciences 19, 79 (2013)
Counting the number of N-step self-avoiding walks (SAWs) on a lattice is one of the most difficult problems of enumerative combinatorics. Once we give up calculating the exact number of them, however, we have a chance to apply powerful computational
Externí odkaz:
http://arxiv.org/abs/1304.7352
Autor:
Shirai, Nobu C., Kikuchi, Macoto
Publikováno v:
J. Phys.: Conf. Ser. 454 012039 (2013)
We develop statistical enumeration methods for self-avoiding walks using a powerful sampling technique called the multicanonical Monte Carlo method. Using these methods, we estimate the numbers of the two dimensional N-step self-avoiding walks up to
Externí odkaz:
http://arxiv.org/abs/1212.2181
Autor:
Saito, Nen, Kikuchi, Macoto
Publikováno v:
New Journal of Physics 15 (2013) 053037 (12pp)
Dynamics in biological networks are in general robust against several perturbations. We investigate a coupled map network as a model motivated by gene regulatory networks and design systems which are robust against phenotypic perturbations (perturbat
Externí odkaz:
http://arxiv.org/abs/1205.3944
How molecular motors like Kinesin regulates the affinity to the rail protein in the process of ATP hydrolysis remains to be uncovered. To understand the regulation mechanism, we investigate the structural fluctuation of KIF1A in different nucleotide
Externí odkaz:
http://arxiv.org/abs/0802.0029