Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A

Autor: Liu L, Lu J, Allan BW, Tang Y, Tetreault J, Chow C, Barmettler B, Nelson J, Bina H, Huang L, Wroblewski VJ, Kikly K

Publikováno v: Journal of Inflammation Research, Vol 2016, Iss Issue 1, Pp 39-50 (2016)

Ling Liu,1 Jirong Lu,1 Barrett W Allan,2 Ying Tang,2 Jonathan Tetreault,1 Chi-kin Chow,1 Barbra Barmettler,2 James Nelson,2 Holly Bina,1 Lihua Huang,3 Victor J Wroblewski,4 Kristine Kikly1 1Biotechnology Discovery Research, Indianapolis, IN, 2Applied

Externí odkaz: https://doaj.org/article/5e331cf6122443a39273d7248c25dc03

Generation and Characterization of Mirikizumab, a Humanized Monoclonal Antibody Targeting the p19 Subunit of IL-23.

Autor: Steere B; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana steere_boyd_a@lilly.com., Beidler C; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana., Martin A; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana., Bright S; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana., Kikly K; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana., Benschop RJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2023 Nov; Vol. 387 (2), pp. 180-187. Date of Electronic Publication: 2023 Sep 15.

Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt).

Autor: Lugar CW; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Clarke CA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Morphy R; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Rudyk H; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Sapmaz S; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Stites RE; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Vaught GM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Furness K; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Broughton HB; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Durst GL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Clawson DK; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Stout SL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Guo SY; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Durbin JD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Stayrook KR; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Edmondson DD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Kikly K; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., New NE; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Bina HA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Chambers MG; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Shetler P; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Chang WY; Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California 92121, United States., Chang VC; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Barr R; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Gough WH; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Steele JP; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Getman B; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Patel N; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Mathes BM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Richardson TI; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 5470-5484. Date of Electronic Publication: 2021 Apr 14.

Insights of Expression Profile of Chemokine Family in Inflammatory Bowel Diseases and Carcinogenesis.

Autor: Zhang, Yinjie^1,2 (AUTHOR) zhyj@sxu.edu.cn, Jin, Yue^1,2 (AUTHOR) jinyueyaoyao@163.com, Wang, Yanjing¹ (AUTHOR) wangyanjing@sjtu.edu.cn, Wang, Siyi¹ (AUTHOR) wangsiyi_sjtu@163.com, Niu, Yuchen¹ (AUTHOR) nyc123@sjtu.edu.cn, Ma, Buyong¹ (AUTHOR) mabuyong@sjtu.edu.cn, Li, Jingjing¹ (AUTHOR) lijj@sjtu.edu.cn

Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10857. 12p.

Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody.

Autor: Boyles JS; Biotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, IN, USA., Beidler CB; Lilly Biotechnology Center, Lilly Research Laboratories, Eli Lilly and Company , San Diego, CA, USA., Strifler BA; Biotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, IN, USA., Girard DS; Lilly Biotechnology Center, Lilly Research Laboratories, Eli Lilly and Company , San Diego, CA, USA., Druzina Z; Discovery Chemistry Research Technologies, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, IN, USA., Durbin JD; Discovery Chemistry Research Technologies, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, IN, USA., Swearingen ML; Oncology Research, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, IN, USA., Lee LN; Oncology Research, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, IN, USA., Kikly K; Immunology Discovery, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, IN, USA., Chintharlapalli S; Oncology Research, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, IN, USA., Witcher DR; Biotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, IN, USA.

Publikováno v: MAbs [MAbs] 2020 Jan-Dec; Vol. 12 (1), pp. 1831880.