Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Kika Konstantinou"'
Autor:
Richard D Riley, Nadine E Foster, Andrea Cherrington, Siobhan Stynes, Kym IE Snell, Kika Konstantinou, Noor Daud, Raymond Ostelo, John O'Dowd
Publikováno v:
BMJ Open, Vol 13, Iss 11 (2023)
Introduction Sciatica can be very painful and, in most cases, is due to pressure on a spinal nerve root from a disc herniation with associated inflammation. For some patients, the pain persists, and one management option is a spinal epidural steroid
Externí odkaz:
https://doaj.org/article/75a763ce6a994b44b4f71075b39cb87f
Publikováno v:
BMC Musculoskeletal Disorders, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background Sciatica is common and associated with significant impacts for the individual and society. The SCOPiC randomised controlled trial (RCT) (trial registration: ISRCTN75449581 ) tested stratified primary care for sciatica by subgroupi
Externí odkaz:
https://doaj.org/article/c37f06b886a24ac4b8d0942649ca241f
Autor:
Kika Konstantinou, Kate M. Dunn, Danielle van der Windt, Reuben Ogollah, Vinay Jasani, Nadine E. Foster, the SCOPiC study team
Publikováno v:
BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Sciatica is a painful condition managed by a stepped care approach for most patients. Currently, there are no decision-making tools to guide matching care pathways for patients with sciatica without evidence of serious pathology,
Externí odkaz:
https://doaj.org/article/ec97faba3a93411bbaeec5733e6af19b
Publikováno v:
BMC Health Services Research, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background There is limited research on the economic burden of low back-related leg pain, including sciatica. The aim of this study was to describe healthcare resource utilisation and factors associated with cost and health outcomes in prima
Externí odkaz:
https://doaj.org/article/f58974b0ae2e4716909fcb7ad9c5d922
Publikováno v:
BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-6 (2019)
Abstract Background There is increasing interest in the role of pro-inflammatory cytokines in the pathogenesis of sciatica and whether these could be potential targets for treatment. We sought to investigate serum biomarker levels in patients with lo
Externí odkaz:
https://doaj.org/article/56f82c68c5c24a1a887deb219ca50fd1
Autor:
Nadine E Foster, Kika Konstantinou, Martyn Lewis, Reuben Ogollah, Benjamin Saunders, Jesse Kigozi, Sue Jowett, Bernadette Bartlam, Majid Artus, Jonathan C Hill, Gemma Hughes, Christian D Mallen, Elaine M Hay, Danielle A van der Windt, Michelle Robinson, Kate M Dunn
Publikováno v:
Health Technology Assessment, Vol 24, Iss 49 (2020)
Background: Sciatica has a substantial impact on patients and society. Current care is ‘stepped’, comprising an initial period of simple measures of advice and analgesia, for most patients, commonly followed by physiotherapy, and then by more int
Externí odkaz:
https://doaj.org/article/1d0a7313bebd4a48a84f9d9d98fc6c3f
Autor:
Nefyn H. Williams, Alison Jenkins, Nia Goulden, Zoe Hoare, Dyfrig A. Hughes, Eifiona Wood, Nadine E. Foster, David Walsh, Dawn Carnes, Valerie Sparkes, Elaine M. Hay, John Isaacs, Kika Konstantinou, Dylan Morrissey, Jaro Karppinen, Stephane Genevay, Clare Wilkinson
Publikováno v:
Trials, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Adalimumab, a biological treatment targeting tumour necrosis factor α, might be useful in sciatica. This paper describes the challenges faced when developing a new treatment pathway for a randomised controlled trial of adalimumab
Externí odkaz:
https://doaj.org/article/6cb9da34ae7d4b6da2eb2181828032d7
Autor:
Nadine E. Foster, Kika Konstantinou, Martyn Lewis, Reuben Ogollah, Kate M. Dunn, Danielle van der Windt, Ruth Beardmore, Majid Artus, Bernadette Bartlam, Jonathan C. Hill, Sue Jowett, Jesse Kigozi, Christian Mallen, Benjamin Saunders, Elaine M. Hay
Publikováno v:
BMC Musculoskeletal Disorders, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background Sciatica has a substantial impact on patients, and is associated with high healthcare and societal costs. Although there is variation in the clinical management of sciatica, the current model of care usually involves an initial pe
Externí odkaz:
https://doaj.org/article/dcff64d535924e5abf41f93f55c66c4a
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0191852 (2018)
BackgroundIdentification of sciatica may assist timely management but can be challenging in clinical practice. Diagnostic models to identify sciatica have mainly been developed in secondary care settings with conflicting reference standard selection.
Externí odkaz:
https://doaj.org/article/01a0cabb4e124ba9b1b739f2c43886e1
Autor:
Nefyn H Williams, Alison Jenkins, Nia Goulden, Zoe Hoare, Dyfrig A Hughes, Eifiona Wood, Nadine E Foster, David A Walsh, Dawn Carnes, Valerie Sparkes, Elaine M Hay, John Isaacs, Kika Konstantinou, Dylan Morrissey, Jaro Karppinen, Stephane Genevay, Clare Wilkinson
Publikováno v:
Health Technology Assessment, Vol 21, Iss 60 (2017)
Background: Biological treatments such as adalimumab (Humira®; AbbVie Ltd, Maidenhead, UK) are antibodies targeting tumour necrosis factor alpha, released from ruptured intervertebral discs, which might be useful in sciatica. Recent systematic revie
Externí odkaz:
https://doaj.org/article/74c1f60f2b574c47be80d1e59d605609