Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Kiira Ratia"'
Autor:
Amrita Salvi, Alexandria N. Young, Andrew C. Huntsman, Melissa R. Pergande, Melissa A. Korkmaz, Rathnayake A. Rathnayake, Brittney K. Mize, A. Douglas Kinghorn, Xiaoli Zhang, Kiira Ratia, Markus Schirle, Jason R. Thomas, Scott M. Brittain, Claude Shelton, Leslie N. Aldrich, Stephanie M. Cologna, James R. Fuchs, Joanna E. Burdette
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract PHY34 is a synthetic small molecule, inspired by a compound naturally occurring in tropical plants of the Phyllanthus genus. PHY34 was developed to have potent in vitro and in vivo anticancer activity against high grade serous ovarian cancer
Externí odkaz:
https://doaj.org/article/e4c4de122bed46cdace434fd84397a5c
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0210305 (2019)
Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5) has been shown to be important in maintaining cellular function in cancer, and its expression is upregulated through multiple, unique pathways in certain cancers, including laryngeal, glioblas
Externí odkaz:
https://doaj.org/article/f5339585051d46aa9651346f428ce2fa
Publikováno v:
Microbial Cell, Vol 3, Iss 2, Pp 53-64 (2016)
The formation of small Aβ42 oligomers has been implicated as a toxic species in Alzheimer disease (AD). In strong support of this hypothesis we found that overexpression of Yap1802, the yeast ortholog of the human AD risk factor, phosphatidylinosito
Externí odkaz:
https://doaj.org/article/e75f1d33dc05436a90b47e0a32b0f50f
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d8f5d47b6baea4fefc21943454287a0
https://doi.org/10.1002/0471266949.bmc054.pub2
https://doi.org/10.1002/0471266949.bmc054.pub2
Autor:
Yangfeng Li, Katherine Dye, Fei Huang, Rui Xiong, Zhengnan Shen, Gregory R. J. Thatcher, Lauren M. Gutgesell, Oleksii Dubrovskyi, Jiong Zhao, Debra A. Tonetti, Huiping Zhao, Kiira Ratia
Publikováno v:
J Med Chem
Acquired resistance to fulvestrant and palbociclib is a new challenge to treatment of estrogen receptor positive (ER+) breast cancer. ER is expressed in most resistance settings; thus, bromodomain and extra-terminal protein inhibitors (BETi) that tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f619038ea8d363dd7d7d2254c977a94e
https://doi.org/10.1021/acs.jmedchem.0c00456
https://doi.org/10.1021/acs.jmedchem.0c00456
Autor:
Saad Alqarni, Lijun Rong, Yangfeng Li, Hyun Lee, Fei Huang, Youngjin Kwon, Rui Xiong, Zhengnan Shen, Deyu Kong, Oleksii Dubrovskyi, Laura Cooper, Kiira Ratia, Gregory R. J. Thatcher
Publikováno v:
Journal of Medicinal Chemistry
bioRxiv
bioRxiv
Antiviral agents blocking SARS-CoV-2 viral replication are desperately needed to complement vaccination to end the COVID-19 pandemic. Viral replication and assembly are entirely dependent on two viral cysteine proteases: 3C-like protease (3CLpro) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce88db71cdeea671844b11248a4fce3
http://europepmc.org/articles/PMC8547495
http://europepmc.org/articles/PMC8547495
Autor:
Chaitanya Aggarwal, Juan Cristobal Jimenez, Hyun Lee, George E. Chlipala, Kiira Ratia, Michael J. Federle
Publikováno v:
mBio, Vol 6, Iss 3 (2015)
ABSTRACT Bacteria coordinate a variety of social behaviors, important for both environmental and pathogenic bacteria, through a process of intercellular chemical signaling known as quorum sensing (QS). As microbial resistance to antibiotics grows mor
Externí odkaz:
https://doaj.org/article/8af6f002ca6444c0b44f1c3d2b9d3664
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004113 (2014)
Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes a papain-like protease (PLpro) with both deubiquitinating (DUB) and deISGylating activities that are proposed to counteract the post-translational modification of signaling molecules th
Externí odkaz:
https://doaj.org/article/4ba3475c68814eeabbd9182648e77f5b
Autor:
Kiira Ratia, Samuel H Light, Aleksandar Antanasijevic, Wayne F Anderson, Michael Caffrey, Arnon Lavie
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89356 (2014)
A vibrant and healthy gut flora is essential for preventing the proliferation of Clostridium difficile, a pathogenic bacterium that causes severe gastrointestinal symptoms. In fact, most C. difficile infections (CDIs) occur after broad-spectrum antib
Externí odkaz:
https://doaj.org/article/9c5dcf45f6e44ba8b49617f278a29cd1
Autor:
Lijun Rong, Alqarni S, Kiira Ratia, Yangfeng Li, Oleksii Dubrovskyi, Fei Huang, Kong D, Youjeong Kwon, Rui Xiong, Zhengnan Shen, Lisa Noelle Cooper, Gregory R. J. Thatcher, Hyun Lee
Antiviral agents blocking SARS-CoV-2 viral replication are desperately needed to complement vaccination to end the COVID-19 pandemic. Viral replication and assembly are entirely dependent on two viral cysteine proteases: 3C-like protease (3CLpro) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2be4ec42dce95f323eff2a7cc9862ce4
https://doi.org/10.1101/2021.02.13.431008
https://doi.org/10.1101/2021.02.13.431008
