A stable α-lactam as electrophilic warhead for bioconjugation and proteomic profiling

Autor: Mahía Moros, Alejandro José, Kiib, Anders Engsted, Nisavic, Marija, Palmfeldt, Johan, Poulsen, Thomas

Publikováno v: Mahía Moros, A J, Kiib, A E, Nisavic, M, Palmfeldt, J & Poulsen, T 2022, ' A stable α-lactam as electrophilic warhead for bioconjugation and proteomic profiling ', EMBO Chemical Biology, Heidelberg, Germany, 05/09/2022-08/09/2022 .
Mahía Moros, A J, Kiib, A E, Nisavic, M, Palmfeldt, J & Poulsen, T 2022, ' A stable α-lactam as electrophilic warhead for bioconjugation and proteomic profiling ', 22nd Tetrahedron Symposium, Lisbon, Portugal, 28/06/2022-01/07/2022 .

Electrophilic warheads are one of the key pillars upon which chemical biology is founded, constituting the anchor point for the design of targeted covalent inhibitors, the identification of novel therapeutic targets, and the development of a wide div

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