Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kieu Chu"'
Autor:
John Morser, Imadul Islam, Cornell Mallari, Elena Ho, Marc Adler, Kumar Emayan, Gary Phillips, Shendong Yuan, Marc Whitlow, Christopher W. West, David R. Light, Giovanna Gualtieri, Drew Sukovich, Ulrich Bothe, Zheng Chang, Kieu Chu, Judi Bryant, Deborah Chen, Caralee Schaefer, Brad O. Buckman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3372-3375
We report here the design and synthesis of a novel series of benzylamines that are potent and selective inhibitors of uPA with promising oral availability in rat. Further evaluation of one representative (ZK824859) of the new structural class showed
Autor:
Gary Phillips, Rebecca Pulk, Christopher W. West, Danny Arnaiz, Shendong Yuan, Kieu Chu, Marc Adler, David R. Light, Deborah Chen, Elena Ho, Giovanna Gualtieri, Marc Whitlow, Christoph Huwe, Judi Bryant, Drew Sukovich
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(19)
In this Letter we report the synthesis and evaluation of a series of non-amidine inhibitors of Urokinase Plasminogen Activator (uPA). Starting from compound 1, a significant change provided compounds in which the amidine, binding in the S1 pocket, wa
Autor:
Imadul Islam, Paul Hrvatin, Kieu Chu, Marc Whitlow, Brad O. Buckman, Marc Adler, Drew Sukovich, John Morser, Christopher West, Shendong Yuan, Judi Bryant, Zheng Chang, Kumar Emayan
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 64(Pt 2)
This article reports the crystal structures of inhibitors of the functional form of thrombin-activatable fibrinolysis inhibitor (TAFIa). In vivo experiments indicate that selective inhibitors of TAFIa would be useful in the treatment of heart attacks
Autor:
Jean-Michel Boursiquot, Patrice This, Carole P. Meredith, Henrik Johansson, Kieu Chu, John E. Bowers
Publikováno v:
Science
Science, American Association for the Advancement of Science, 1999, 285, pp.1562-1565
Science, American Association for the Advancement of Science, 1999, 285, pp.1562-1565
The origins of the classic European wine grapes (Vitis vinifera) have been the subject of much speculation. In a search for parental relationships, microsatellite loci were analyzed in more than 300 grape cultivars. Sixteen wine grapes that have long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10717923f8b49c34e658b17dd63b209
https://hal.inrae.fr/hal-02699130
https://hal.inrae.fr/hal-02699130
Autor:
Adler, Marc, Buckman, Brad, Bryant, Judi, Zheng Chang, Kieu Chu, Emayan, Kumar, Hrvatin, Paul, Islam, Imadul, Morser, John, Sukovich, Drew, West, Christopher, Yuan, Shendong, Whitlow, Marc
Publikováno v:
Acta Crystallographica: Section D (Wiley-Blackwell); Feb2008, Vol. 64 Issue 2, p149-157, 9p