Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kiet Le Van"'
Autor:
Laszlo Hevesi, Allan Guiguen, Pierre Vandurm, Carine Van Lint, Christelle Cardona, Kiet Le Van, Catherine Michaux, Benoît Georges, Gladys Mbemba, Christine Cauvin, Jean-François Mouscadet, Johan Wouters
Publikováno v:
European Journal of Medicinal Chemistry. 46:1749-1756
New quinolonyl diketo acid compounds bearing various substituents at position 6 of the quinolone scaffold were designed and synthesized as potential HIV-1 integrase inhibitors. These new compounds were evaluated for their antiviral and anti-integrase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f259a89cb440f917d9e2a3267dd85375
https://doi.org/10.1016/j.ejmech.2011.02.028
https://doi.org/10.1016/j.ejmech.2011.02.028
Autor:
Stéphane de Walque, Carine Van Lint, Sandro Boland, Kiet Le Van, Valérie Martinelli, Benoît Georges, François Durant, Christine Cauvin, Laszlo Hevesi, D. Demonte
Publikováno v:
Journal of medicinal chemistry. 52(12)
Several 5-ethyl-6-methyl-4-cycloalkyloxy-pyridin-2(1H)-ones were synthesized and evaluated for their anti HIV-1 activities against wild-type virus and clinically relevant mutant strains. A racemic mixture (10) with methyl substituents at positions 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c154ac7778ec5a382d2e859fd4c9410c
https://pubmed.ncbi.nlm.nih.gov/19469474
https://pubmed.ncbi.nlm.nih.gov/19469474
Autor:
Allan Guiguen, Pierre Vandurm, Christine Cauvin, Valérie Martinelli, Christelle Cardona, Carine Van Lint, Jean-François Mouscadet, Johan Wouters, Laszlo Hevesi, Gladys Mbemba, Benoît Georges, Kiet Le Van
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(16)
Ethyl [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl]-4-hydroxy-2-oxo-3-butenoate 1 and [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoic acid 2 were synthesized as potential HIV-1 integrase inhibitors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e96b8a0e1aac27b5776b4588d3118c
https://pubmed.ncbi.nlm.nih.gov/19556126
https://pubmed.ncbi.nlm.nih.gov/19556126
Autor:
Kiet Le Van, Bernadette Norberg, Christine Cauvin, Benoît Georges, Laszlo Hevesi, Sandro Boland, François Durant
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 58:o964-o965
Structural analysis of the title compound, C16H23NO4, reveals that the pyridine ring and the ester moiety are coplanar. This conformation is stabilized by an intramolecular hydrogen bond between the hydroxyl and ester groups.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c03ee9b54e4641263e598804425d0fef
https://doi.org/10.1107/s1600536802013612
https://doi.org/10.1107/s1600536802013612
Autor:
Kiet Le Van, Christine Cauvin, Stéphane de Walque, Benoît Georges, Sandro Boland, Valérie Martinelli, Dominique Demonté, François Durant, László Hevesi, Carine Van Lint
Publikováno v:
Journal of Medicinal Chemistry; Jun2009, Vol. 52 Issue 12, p3636-3643, 8p