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pro vyhledávání: '"Kieser, A."'
Basket trial designs are a type of master protocol in which the same therapy is tested in several strata of the patient cohort. Many basket trial designs implement borrowing mechanisms. These allow sharing information between similar strata with the
Externí odkaz:
http://arxiv.org/abs/2403.02058
Autor:
Tamimi, Amr, Caldarola, Martin, Hambura, Sebastian, Boffi, Juan C., Noordzij, Niels, Los, Johannes W. N., Guardiani, Antonio, Kooiman, Hugo, Wang, Ling, Kieser, Christian, Braun, Florian, Fognini, Andreas, Prevedel, Robert
Two-photon microscopy (2PM) has become an important tool in biology to study the structure and function of intact tissues in-vivo. However, adult mammalian tissues such as the mouse brain are highly scattering, thereby putting fundamental limits on t
Externí odkaz:
http://arxiv.org/abs/2312.14042
Autor:
Maximilian Pilz, Samuel Zimmermann, Juliane Friedrichs, Enrica Wördehoff, Ulrich Ronellenfitsch, Meinhard Kieser, Johannes A. Vey
Publikováno v:
Systematic Reviews, Vol 13, Iss 1, Pp 1-14 (2024)
Abstract Background Title-abstract screening in the preparation of a systematic review is a time-consuming task. Modern techniques of natural language processing and machine learning might allow partly automatization of title-abstract screening. In p
Externí odkaz:
https://doaj.org/article/48ede6f1bd4f4ec5882c8ce8c0cd6cc0
Autor:
Stephen Schüürhuis, Gernot Wassmer, Meinhard Kieser, Friedrich Pahlke, Cornelia Ursula Kunz, Carolin Herrmann
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background In group-sequential designs, it is typically assumed that there is no time gap between patient enrollment and outcome measurement in clinical trials. However, in practice, there is usually a lag between the two time points. This c
Externí odkaz:
https://doaj.org/article/6aef60e81a4b49ffa7cb6ae06dab44fa
Autor:
Min Chen, Lukas Daniel Sauer, Mika Herwig, Jessica Jesser, Meinhard Kieser, Arne Potreck, Markus Möhlenbruch, Peter Arthur Ringleb, Silvia Schönenberger
Publikováno v:
Neurological Research and Practice, Vol 6, Iss 1, Pp 1-8 (2024)
Abstract Background Optimal blood pressure management during endovascular stroke treatment is not certain. We hypothesized that time or proportion of intraprocedural systolic blood pressure spent in a range around admission blood pressure might be as
Externí odkaz:
https://doaj.org/article/266cf0c3e46747b2820ed9efd728a5c2
In basket trials a treatment is investigated in several subgroups. They are primarily used in oncology in early clinical phases as single-arm trials with a binary endpoint. For their analysis primarily Bayesian methods have been suggested, as they al
Externí odkaz:
http://arxiv.org/abs/2309.06988
Generative AI technologies such as large language models show novel potentials to enhance educational research. For example, generative large language models were shown to be capable to solve quantitative reasoning tasks in physics and concept tests
Externí odkaz:
http://arxiv.org/abs/2307.14475
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background In clinical trials, the determination of an adequate sample size is a challenging task, mainly due to the uncertainty about the value of the effect size and nuisance parameters. One method to deal with this uncertainty is a sample
Externí odkaz:
https://doaj.org/article/665fb45aa28a4e7f8cf22244c7b7e038
Autor:
Arleta A. Luczejko, Naomi Leona Werkmann, K. Hagelweide, R. Stark, S. Weigelt, H. Christiansen, M. Kieser, K. Otto, C. Reck, R. Steinmayr, L. Wirthwein, A.-L. Zietlow, C. Schwenck, the COMPARE-family research group
Publikováno v:
Child and Adolescent Psychiatry and Mental Health, Vol 18, Iss 1, Pp 1-16 (2024)
Abstract Background Children of parents with a mental illness (COPMI) have multiple psychological and developmental risks, including an increased lifetime risk of developing a mental illness themselves. Emotion regulation (ER) has been identified as
Externí odkaz:
https://doaj.org/article/26cbeec1d5314dcdb877a2553cb48e0b
Autor:
Maura M. Zylla, Johannes Leiner, Ann-Kathrin Rahm, Tobias Hoffmann, Patrick Lugenbiel, Patrick Schweizer, Christine Mages, Derliz Mereles, Meinhard Kieser, Eberhard Scholz, Hugo A. Katus, Norbert Frey, Dierk Thomas
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundHeart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) often coincide. Female sex is associated with both increased prevalence of HFpEF and reduced therapeutic efficacy of catheter ablation of AF. This sub-analy
Externí odkaz:
https://doaj.org/article/ae3e1191ad254d2f90c70a980a4b58a5