Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kiersten A Henderson"'
Publikováno v:
eLife, Vol 5 (2016)
Mitochondrial dysfunction is a hallmark of aging, and underlies the development of many diseases. Cells maintain mitochondrial homeostasis through a number of pathways that remodel the mitochondrial proteome or alter mitochondrial content during time
Externí odkaz:
https://doaj.org/article/58fd680ae64c4870a87c5060d7aa9b6e
Publikováno v:
eLife, Vol 3 (2014)
Replicative aging in yeast is asymmetric–mother cells age but their daughter cells are rejuvenated. Here we identify an asymmetry in pH between mother and daughter cells that underlies aging and rejuvenation. Cytosolic pH increases in aging mother
Externí odkaz:
https://doaj.org/article/97925d28da9a49f9a1821bca0d06b3fc
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1002015 (2011)
Somatic mutations contribute to the development of age-associated disease. In earlier work, we found that, at high frequency, aging Saccharomyces cerevisiae diploid cells produce daughters without mitochondrial DNA, leading to loss of respiration com
Externí odkaz:
https://doaj.org/article/b59cb071bda6446b82dd9eaa1cabfc9e
Autor:
Gregory M. Goldgof, Jacob D. Durrant, Sabine Ottilie, Edgar Vigil, Kenneth E. Allen, Felicia Gunawan, Maxim Kostylev, Kiersten A. Henderson, Jennifer Yang, Jake Schenken, Gregory M. LaMonte, Micah J. Manary, Ayako Murao, Marie Nachon, Rebecca Murray, Maximo Prescott, Case W. McNamara, Carolyn W. Slayman, Rommie E. Amaro, Yo Suzuki, Elizabeth A. Winzeler
Publikováno v:
Scientific Reports, Vol 6, Iss 1, Pp 1-13 (2016)
Abstract The spiroindolones, a new class of antimalarial medicines discovered in a cellular screen, are rendered less active by mutations in a parasite P-type ATPase, PfATP4. We show here that S. cerevisiae also acquires mutations in a gene encoding
Externí odkaz:
https://doaj.org/article/18801bf6d83b4da390a0a3ecb536d0c8
Autor:
Zara W. Nelson, Christina K. Leverich, Jessica J. Hsu, Matthew Fitzgibbon, Daniel E. Gottschling, Philip R. Gafken, Kiersten A. Henderson, Nathaniel H. Thayer
Publikováno v:
Proceedings of the National Academy of Sciences. 111:14019-14026
Long-lived proteins have been implicated in age-associated decline in metazoa, but they have only been identified in extracellular matrices or postmitotic cells. However, the aging process also occurs in dividing cells undergoing repeated asymmetric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444e767611952e4458f6cc22d24f9085
https://doi.org/10.1073/pnas.1416079111
https://doi.org/10.1073/pnas.1416079111
Autor:
Rebecca Stanhope, Maximo Prescott, Marie Nachon, Jacob D. Durrant, Carolyn W. Slayman, Sabine Ottilie, Case W. McNamara, Kenneth E. Allen, Rommie E. Amaro, Edgar Vigil, Ayako Murao, Jennifer H. Yang, Felicia Gunawan, Kiersten A. Henderson, Maxim Kostylev, Micah J. Manary, Elizabeth A. Winzeler, Gregory LaMonte, Gregory M. Goldgof, Yo Suzuki, Jake Schenken
Publikováno v:
Scientific Reports
The spiroindolones, a new class of antimalarial medicines discovered in a cellular screen, are rendered less active by mutations in a parasite P-type ATPase, PfATP4. We show here that S. cerevisiae also acquires mutations in a gene encoding a P-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d718c0006ca754954b2105748dbb574d
https://doi.org/10.1038/srep27806
https://doi.org/10.1038/srep27806
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
Mitochondrial dysfunction is a hallmark of aging, and underlies the development of many diseases. Cells maintain mitochondrial homeostasis through a number of pathways that remodel the mitochondrial proteome or alter mitochondrial content during time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485ceefba098384d644954684ee0219b
https://doi.org/10.7554/elife.13943
https://doi.org/10.7554/elife.13943
Publikováno v:
Current Opinion in Cell Biology. 20:723-728
Individual cells of the budding yeast, Saccharomyces cerevisiae, have a limited life span and undergo a form of senescence termed replicative aging. Replicative life span is defined as the number of daughter cells produced by a yeast mother cell befo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f9d36cc1319d1d38124f8b15176212
https://doi.org/10.1016/j.ceb.2008.09.004
https://doi.org/10.1016/j.ceb.2008.09.004
Autor:
Kiersten A. Henderson, Scott Keeney
Publikováno v:
BioEssays. 27:995-998
The synaptonemal complex is a prominent, evolutionarily conserved feature of meiotic prophase. The assembly of this structure is closely linked to meiotic recombination. A recent study in budding yeast reveals an unexpected role in centromere pairing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662349cbab763123aa1645b1d5ad43c1
https://doi.org/10.1002/bies.20310
https://doi.org/10.1002/bies.20310