Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kieren D Marini"'
Autor:
Tracy L Leong, Kieren D Marini, Fernando J Rossello, Samantha N Jayasekara, Prudence A Russell, Zdenka Prodanovic, Beena Kumar, Vinod Ganju, Muhammad Alamgeer, Louis B Irving, Daniel P Steinfort, Craig D Peacock, Jason E Cain, Anette Szczepny, D Neil Watkins
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106862 (2014)
Patient-derived xenograft (PDX) models generated from surgical specimens are gaining popularity as preclinical models of cancer. However, establishment of PDX lines from small cell lung cancer (SCLC) patients is difficult due to very limited amount o
Externí odkaz:
https://doaj.org/article/e0305b2848d84d00ba2426240e5e00e5
Autor:
Fernando J Rossello, Richard W Tothill, Kara Britt, Kieren D Marini, Jeanette Falzon, David M Thomas, Craig D Peacock, Luigi Marchionni, Jason Li, Samara Bennett, Erwin Tantoso, Tracey Brown, Philip Chan, Luciano G Martelotto, D Neil Watkins
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74432 (2013)
Next-generation sequencing (NGS) studies in cancer are limited by the amount, quality and purity of tissue samples. In this situation, primary xenografts have proven useful preclinical models. However, the presence of mouse-derived stromal cells repr
Externí odkaz:
https://doaj.org/article/728a70be11b74d5e9bfec58d72aeeeed
Autor:
Kaja Kostyrko, Marta Román, Alex G. Lee, David R. Simpson, Phuong T. Dinh, Stanley G. Leung, Kieren D. Marini, Marcus R. Kelly, Joshua Broyde, Andrea Califano, Peter K. Jackson, E. Alejandro Sweet-Cordero
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract KRAS is a frequent driver in lung cancer. To identify KRAS-specific vulnerabilities in lung cancer, we performed RNAi screens in primary spheroids derived from a Kras mutant mouse lung cancer model and discovered an epigenetic regulator Ubiq
Externí odkaz:
https://doaj.org/article/bfd9eceda508466c9e02d6a2c91e89f7
Autor:
Samir M. Hanash, Ayumu Taguchi, Edwin J. Ostrin, Herbert Levine, D. Neil Watkins, Jennifer B. Dennison, Eunice N. Murage, Hong Wang, Hiroyuki Katayama, Mohit K. Jolly, Kieren D. Marini, Mitzi Aguilar, Muge Celiktas, Johannes F. Fahrmann, Satyendra C. Tripathi
Supplementary Figure 1: Increased MCAM expression in SCLC; Supplementary Figure 2: Chemoresistant cells showed mesenchymal like features; Supplementary Figure 3: MCAM knockdown in SCLC chemoresistant cells; Supplementary Figure 4; Effect of MCAM knoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b968fee516ad3b640fa73f39ad50447
https://doi.org/10.1158/0008-5472.22414923
https://doi.org/10.1158/0008-5472.22414923
Autor:
Roger J. Daly, Yvonne M.H. Versleijen-Jonkers, Jianmin Wu, Jason E. Cain, Tim R. Mercer, Vijesh Vaghjiani, Kieren D. Marini, Christopher J. Lord, David M. Thomas, Erin E. Heyer, Uta E. Flucke, Amy van de Ven, Sabri A.S. Cebeci, Laurens van Houdt, Anke van Erp, Mandy C. Magias, Howard Chan, Xiuquan Ma, James Blackburn, Melissa H.S. Hillebrandt-Roeffen, Winette T.A. van der Graaf, Myrella Vlenterie, Emmy D.G. Fleuren
This file contains the following supplemental data: Supplemental Table 1. Specific information for MTT cell viability assays with single agents. Supplemental Table 2. Patient characteristics of synovial sarcoma cohort. Supplemental Table 3. Specifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17301feb23bc053623268de070b4f307
https://doi.org/10.1158/0008-5472.22414427.v1
https://doi.org/10.1158/0008-5472.22414427.v1
Autor:
Samir M. Hanash, Ayumu Taguchi, Edwin J. Ostrin, Herbert Levine, D. Neil Watkins, Jennifer B. Dennison, Eunice N. Murage, Hong Wang, Hiroyuki Katayama, Mohit K. Jolly, Kieren D. Marini, Mitzi Aguilar, Muge Celiktas, Johannes F. Fahrmann, Satyendra C. Tripathi
Contains supplementary methods (Gene knockdown and overexpression, Sample preparation and mass spectrometric analysis, BrdU assay, Immunoblotting, Mathematical modeling for regulation of MCAM), supplementary references and supplementary figure legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2260fa94a8b7aef69b3762a4e636ee68
https://doi.org/10.1158/0008-5472.22414926.v1
https://doi.org/10.1158/0008-5472.22414926.v1
Autor:
Roger J. Daly, Yvonne M.H. Versleijen-Jonkers, Jianmin Wu, Jason E. Cain, Tim R. Mercer, Vijesh Vaghjiani, Kieren D. Marini, Christopher J. Lord, David M. Thomas, Erin E. Heyer, Uta E. Flucke, Amy van de Ven, Sabri A.S. Cebeci, Laurens van Houdt, Anke van Erp, Mandy C. Magias, Howard Chan, Xiuquan Ma, James Blackburn, Melissa H.S. Hillebrandt-Roeffen, Winette T.A. van der Graaf, Myrella Vlenterie, Emmy D.G. Fleuren
Despite intensive multimodal treatment of sarcomas, a heterogeneous group of malignant tumors arising from connective tissue, survival remains poor. Candidate-based targeted treatments have demonstrated limited clinical success, urging an unbiased an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43c89fc97229226c3aa707ce5d1129e4
https://doi.org/10.1158/0008-5472.c.6508976.v1
https://doi.org/10.1158/0008-5472.c.6508976.v1
Autor:
Samir M. Hanash, Ayumu Taguchi, Edwin J. Ostrin, Herbert Levine, D. Neil Watkins, Jennifer B. Dennison, Eunice N. Murage, Hong Wang, Hiroyuki Katayama, Mohit K. Jolly, Kieren D. Marini, Mitzi Aguilar, Muge Celiktas, Johannes F. Fahrmann, Satyendra C. Tripathi
Despite favorable responses to initial therapy, small-cell lung cancer (SCLC) relapse occurs within a year and exhibits resistance to multiple drugs. Because of limited accessibility of patient tissues for research purposes, SCLC patient-derived xeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ffb2addd9eb9156449aa46b8d67c95b
https://doi.org/10.1158/0008-5472.c.6509118.v1
https://doi.org/10.1158/0008-5472.c.6509118.v1
Autor:
Roger J. Daly, Yvonne M.H. Versleijen-Jonkers, Jianmin Wu, Jason E. Cain, Tim R. Mercer, Vijesh Vaghjiani, Kieren D. Marini, Christopher J. Lord, David M. Thomas, Erin E. Heyer, Uta E. Flucke, Amy van de Ven, Sabri A.S. Cebeci, Laurens van Houdt, Anke van Erp, Mandy C. Magias, Howard Chan, Xiuquan Ma, James Blackburn, Melissa H.S. Hillebrandt-Roeffen, Winette T.A. van der Graaf, Myrella Vlenterie, Emmy D.G. Fleuren
Protein-protein network analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c367eace688b397451f5f24cf6b808
https://doi.org/10.1158/0008-5472.22414430.v1
https://doi.org/10.1158/0008-5472.22414430.v1
Autor:
Samir M. Hanash, Ayumu Taguchi, Edwin J. Ostrin, Herbert Levine, D. Neil Watkins, Jennifer B. Dennison, Eunice N. Murage, Hong Wang, Hiroyuki Katayama, Mohit K. Jolly, Kieren D. Marini, Mitzi Aguilar, Muge Celiktas, Johannes F. Fahrmann, Satyendra C. Tripathi
MassSpec counts for proteins identified with atleast two fold difference between H69AR and H69.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450903139c844f235ad16bf724947433
https://doi.org/10.1158/0008-5472.22414917.v1
https://doi.org/10.1158/0008-5472.22414917.v1