Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Kieran P, O'Dea"'
Autor:
Xiaomeng Li, Enqiang Chang, Jiang Cui, Hailin Zhao, Cong Hu, Kieran P. O’Dea, Nikhil Tirlapur, Gianfranco Balboni, Jiaqiang Zhang, Liming Ying, Daqing Ma
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Colorectal cancer (CRC) is the third most predominant malignancy in the world. Although the importance of immune system in cancer development has been well established, the underlying mechanisms remain to be investigated further. Here we studied a no
Externí odkaz:
https://doaj.org/article/763bedc5daa94c8f92d4bbc6091b9516
Autor:
Sanooj Soni, Kieran P. O’Dea, Eiko Abe, Maryam Khamdan, Sneh V. Shah, Padmini Sarathchandra, Michael R. Wilson, Masao Takata
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Intra-alveolar microvesicles (MVs) are important mediators of inter-cellular communication within the alveolar space, and are key components in the pathophysiology of lung inflammation such as acute respiratory distress syndrome (ARDS). Despite the a
Externí odkaz:
https://doaj.org/article/265851e6466b47a68ddcac4cfd27882e
Autor:
Ying Ying Tan, Kieran P. O’Dea, Diianeira Maria Tsiridou, Aurelie Pac Soo, Marissa W. Koh, Florence Beckett, Masao Takata
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 68:140-149
Blood-borne myeloid cells, neutrophils and monocytes, play a central role in the development of indirect acute lung injury (ALI) during sepsis and non-infectious systemic inflammatory response syndrome (SIRS). By contrast, the contribution of circula
Autor:
Kieran P. O’Dea, Ying Ying Tan, Sneh Shah, Brijesh V Patel, Kate C Tatham, Mike R. Wilson, Sanooj Soni, Masao Takata
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Microvesicles (MVs), a plasma membrane-derived subclass of extracellular vesicles, are produced and released into the circulation during systemic inflammation, yet little is known of cell/tissue-specific uptake of MVs under these conditions. We hypot
Externí odkaz:
https://doaj.org/article/8af85ed349d2405f8670d4761a8c6660
Autor:
Anthony C Gordon, Shalini Santhakumaran, Farah Al-Beidh, Robert ML Orme, Gavin D Perkins, Mervyn Singer, Daniel F McAuley, Alexina J Mason, Josie K Ward, Kieran P O’Dea, Timothy Felton, Mary Cross, Janis Best-Lane, Jonas Lexow, Ashley Campbell, Deborah Ashby
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 5, Iss 6 (2018)
Background: In septic shock, cardiovascular resuscitation using catecholamine vasopressors and inotropes is standard therapy, but catecholamines have important side effects. Levosimendan (Simdax®; Orion Pharma, Newbury, UK) is a calcium-sensitising
Externí odkaz:
https://doaj.org/article/0fdb3781dce7473aa22a1e9ace439a37
Publikováno v:
The FASEB Journal. 36
Publikováno v:
The FASEB Journal. 36
Autor:
Kieran P O'Dea, John R Porter, Nikhil Tirlapur, Umar Katbeh, Suveer Singh, Jonathan M Handy, Masao Takata
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167801 (2016)
Microvesicles are cell-derived signaling particles emerging as important mediators and biomarkers of systemic inflammation, but their production in severe burn injury patients has not been described. In this pilot investigation, we measured circulati
Externí odkaz:
https://doaj.org/article/29a7445cbe034d0eb4f83ee20f03abe6
Autor:
Mark R. Johnson, Kieran P. O'Dea, Julia Zöllner, Lydia F Edey, Masao Takata, Laura G. Howe, James Leiper
Publikováno v:
Shock. 53:199-207
Our previous work has shown that pregnancy exacerbates the hypotensive response to both infection and lipopolysaccharide (LPS). The high levels of progesterone (P4) associated with pregnancy have been suggested to be responsible for the pregnancy-ind
Autor:
Laura G. Howe, David A. MacIntyre, Xia Zheng, Lydia F Edey, Mark R. Johnson, Kieran P. O'Dea, Weiwei Cheng, Renyi Hua, Bronwen R. Herbert, Masao Takata, Philip R. Bennett
Publikováno v:
Biology of Reproduction. 102:445-455
In our earlier work, we found that intrauterine (i.u.) and intraperitoneal (i.p.) injection of LPS (10-µg serotype 0111:B4) induced preterm labor (PTL) with high pup mortality, marked systemic inflammatory response and hypotension. Here, we used bot