Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kieran M. Mcgrail"'
Autor:
Daniel J. Perry, Melanie R. Shapiro, Sonya W. Chamberlain, Irina Kusmartseva, Srikar Chamala, Leandro Balzano-Nogueira, Mingder Yang, Jason O. Brant, Maigan Brusko, MacKenzie D. Williams, Kieran M. McGrail, James McNichols, Leeana D. Peters, Amanda L. Posgai, John S. Kaddis, Clayton E. Mathews, Clive H. Wasserfall, Bobbie-Jo M. Webb-Robertson, Martha Campbell-Thompson, Desmond Schatz, Carmella Evans-Molina, Alberto Pugliese, Patrick Concannon, Mark S. Anderson, Michael S. German, Chester E. Chamberlain, Mark A. Atkinson, Todd M. Brusko
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-16 (2023)
Abstract The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type 1 diabetes (T1D), maturity-onset diabetes of the young (MODY), cystic fibrosis-re
Externí odkaz:
https://doaj.org/article/0ad4cb66140840c5abd02c69201bad7b
Autor:
Carmella Evans-Molina, Clive Wasserfall, Megan T Legge, Eleni Beli, Craig A. Beam, Ryan Silk, Kieran M. Mcgrail, Linda A. DiMeglio, Mark A. Atkinson, Stephanie Woerner, Maria B. Grant
Publikováno v:
Diabetologia
Beam, C A, Beli, E, Wasserfall, C H, Woerner, S E, Legge, M T, Evans-Molina, C, McGrail, K M, Silk, R, Grant, M B, Atkinson, M A & DiMeglio, L A 2021, ' Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes ', Diabetologia . https://doi.org/10.1007/s00125-021-05468-6
Beam, C A, Beli, E, Wasserfall, C H, Woerner, S E, Legge, M T, Evans-Molina, C, McGrail, K M, Silk, R, Grant, M B, Atkinson, M A & DiMeglio, L A 2021, ' Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes ', Diabetologia . https://doi.org/10.1007/s00125-021-05468-6
Aims/hypothesis The circadian clock influences both diabetes and immunity. Our goal in this study was to characterise more thoroughly the circadian patterns of immune cell populations and cytokines that are particularly relevant to the immune patholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5304384a2a7eb86434e13bd1acc63ddb
http://europepmc.org/articles/PMC8245361
http://europepmc.org/articles/PMC8245361
Autor:
Desmond A. Schatz, Clive Wasserfall, James J. Ross, Todd M. Brusko, Rhonda Bacher, Mark A. Atkinson, Xiaoru Dong, Kieran M. Mcgrail, Amanda L. Posgai, Martha Campbell-Thompson, Andrew Muir, Michael J. Haller, Xia Li, Daniel J. Perry
Publikováno v:
Diabetes
Exocrine pancreas abnormalities are increasingly recognized as features of type 1 diabetes. We previously reported reduced serum trypsinogen levels and in a separate study, smaller pancreata at and prior to disease onset. We hypothesized that three p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee46928f57e8f4105deeee8dc70e618e
https://doi.org/10.2337/db20-0995
https://doi.org/10.2337/db20-0995
Autor:
C Ramsey Grace, Mark A. Atkinson, Srikar Chamala, Daniel J. Perry, Desmond A. Schatz, MacKenzie D. Williams, Andrew Muir, Kieran M. Mcgrail, Amanda L. Posgai, Rhonda Bacher, Michael J. Haller, Clive Wasserfall, Todd M. Brusko
We and others previously demonstrated that a type 1 diabetes genetic risk score (GRS) improves the ability to predict disease progression and onset in at-risk subjects with islet autoantibodies. Here, we hypothesized that GRS and islet autoantibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a336ae899801e6076f5656be005ea1d
https://doi.org/10.2337/figshare.13516808.v1
https://doi.org/10.2337/figshare.13516808.v1
Autor:
Mark A. Atkinson, Kieran M. Mcgrail, Craig A. Beam, Linda A. DiMeglio, Stephanie Woerner, Carmella Evans-Molina, Clive Wasserfall, Eleni Beli
Publikováno v:
Diabetes. 68
Purpose: Immune populations and cytokines are known to exhibit distinct circadian ("daily") variations. We sought to characterize circadian-related immune variation in persons with type 1 diabetes (T1D) to ascertain whether sampling of peripheral imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3541ec646e4b9bbeaed70efe352dbebd
https://doi.org/10.2337/db19-1729-p
https://doi.org/10.2337/db19-1729-p
Autor:
Maigan A. Hulme, Clive Wasserfall, Desmond A. Schatz, Michael J. Haller, Clayton E. Mathews, Todd M. Brusko, Jonathan J. Shuster, Kieran M. Mcgrail, Amanda L. Posgai, Mark A. Atkinson, Miriam Cintron
Publikováno v:
Clinical and Experimental Immunology. 183:350-357
Summary Granulocyte colony-stimulating factor (G-CSF) has been used to restore immune competence following chemoablative cancer therapy and to promote immunological tolerance in certain settings of autoimmunity. Therefore, we tested the potential of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c492156b119df7090232698097d7c35
https://doi.org/10.1111/cei.12731
https://doi.org/10.1111/cei.12731
Autor:
Kieran M. Mcgrail, Amanda L. Posgai, Desmond A. Schatz, Clive Wasserfall, James J. Ross, Todd M. Brusko, Daniel J. Perry, Michael J. Haller, Mark A. Atkinson
Publikováno v:
Diabetes. 67
Recent studies demonstrated reduced serum trypsinogen levels as well as pancreatic weight/volume in patients with type 1 diabetes (T1D) and nondiabetic/autoantibody (AAb)-positive subjects. Histological defects including increased CD8+ T cell infiltr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43596aad1fe8d5d5795871144e0408ed
https://doi.org/10.2337/db18-1543-p
https://doi.org/10.2337/db18-1543-p
Autor:
Dax Fu, Hao Wan, Mark A. Atkinson, Hongjie Dai, Kieran M. Mcgrail, Chengfeng Merriman, Yongye Liang, Clive Wasserfall
Identified as a major biomarker for type 1 diabetes (T1D) diagnosis, zinc transporter 8 autoantibody (ZnT8A) has shown promise for staging disease risk and disease diagnosis. However, existing assays for ZnT8 autoantibody (ZnT8A) are limited to detec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1cdd24b83db418aa5d0f2bc91e2fc4
https://europepmc.org/articles/PMC5617307/
https://europepmc.org/articles/PMC5617307/
Autor:
Andrew R Schultz, Martha Campbell-Thompson, Desmond A. Schatz, Andrew Muir, Jonathan J. Shuster, Michael J. Haller, Xia Li, Todd M. Brusko, Faming Liang, Clive Wasserfall, Kieran M. Mcgrail, Amanda L. Posgai, Mark A. Atkinson
Publikováno v:
Diabetes Care
OBJECTIVE The pancreas in type 1 diabetes exhibits decreased size (weight/volume) and abnormal exocrine morphology. Serum trypsinogen levels are an established marker of pancreatic exocrine function. As such, we hypothesized that trypsinogen levels m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bb216c86ad3915f960d3e31e5cd65f
https://pubmed.ncbi.nlm.nih.gov/28115475
https://pubmed.ncbi.nlm.nih.gov/28115475
Autor:
Kieran M. Mcgrail, Desmond A. Schatz, Mark A. Atkinson, John R. Wingard, Clive Wasserfall, Susan Kelly, Michael J. Haller, Jonathan J. Shuster, Todd M. Brusko, Miriam Cintron
Publikováno v:
Diabetes Care
OBJECTIVE Interest continues to grow regarding the therapeutic potential for umbilical cord blood therapies to modulate autoimmune disease. We conducted an open-label phase I study using autologous umbilical cord blood infusion to ameliorate type 1 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79727b1e06dce2c7afb626735a37eba7
http://europepmc.org/articles/PMC2768209
http://europepmc.org/articles/PMC2768209