Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Kieran Horgan"'
Autor:
Judith M. Bliss, Holly Tovey, Abigail Evans, Chris Holcombe, Kieran Horgan, Elizabeth Mallon, Raghavan Vidya, Anthony Skene, Andrew Dodson, Margaret Hills, Simone Detre, Lila Zabaglo, Jane Banerji, Lucy Kilburn, James P. Morden, John F. R. Robertson, Ian Smith, Mitch Dowsett, the POETIC Trialists
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-16 (2023)
Abstract Purpose Ki67 assessed at diagnosis (Ki67baseline) is an important prognostic factor in primary oestrogen receptor-positive (ER +) breast cancer. Proportional change in Ki67 after 2 weeks (∆Ki672week) is associated with clinical benefit fro
Externí odkaz:
https://doaj.org/article/46abcee1eee44a268049c2e73c029025
Autor:
Melissa Ruth Gannon, David Dodwell, Kieran Horgan, Karen Clements, Jibby Medina, Katie Miller, Min Hae Park, David Alan Cromwell
Publikováno v:
BMJ Oncology, Vol 2, Iss 1 (2023)
Objective Although adjuvant trastuzumab-based treatment (TBT) improves survival for patients with HER2-positive early invasive breast cancer (EIBC), risk of toxicity grows as patient age increases. We examined use of TBT and associated severe acute t
Externí odkaz:
https://doaj.org/article/da581229b60f405ab3d961f3c4556677
Autor:
Lynda Wyld, Malcolm WR Reed, Karen Collins, Sue Ward, Geoff Holmes, Jenna Morgan, Mike Bradburn, Stephen Walters, Maria Burton, Kate Lifford, Adrian Edwards, Kate Brain, Alistair Ring, Esther Herbert, Thompson G Robinson, Charlene Martin, Tim Chater, Kirsty Pemberton, Anne Shrestha, Anthony Nettleship, Paul Richards, Alan Brennan, Kwok Leung Cheung, Annaliza Todd, Helena Harder, Riccardo Audisio, Nicolo Matteo Luca Battisti, Juliet Wright, Richard Simcock, Christopher Murray, Alastair M Thompson, Margot Gosney, Matthew Hatton, Fiona Armitage, Julietta Patnick, Tracy Green, Deirdre Revill, Jacqui Gath, Kieran Horgan, Chris Holcombe, Matt Winter, Jay Naik, Rishi Parmeshwar
Publikováno v:
Programme Grants for Applied Research, Vol 10, Iss 6 (2022)
Background: In breast cancer management, age-related practice variation is widespread, with older women having lower rates of surgery and chemotherapy than younger women, based on the premise of reduced treatment tolerance and benefit. This may contr
Externí odkaz:
https://doaj.org/article/77f7655fdd404d7cbb72026187c711da
Autor:
David A Cromwell, Thompson Robinson, Yasmin Jauhari, Melissa Ruth Gannon, Kieran Horgan, Karen Clements, Jibby Medina, Carmen Tsang, Sarah Shuk-Kay Tang, Ruth Pettengell
Publikováno v:
BMJ Open, Vol 10, Iss 5 (2020)
Objectives Studies that use national datasets to evaluate the management of older women with breast cancer are often constrained by a lack of information on patient fitness. This study constructed a frailty index for use with secondary care administr
Externí odkaz:
https://doaj.org/article/cf0e9fedb20742a9a2cf0f09da22e0d9
Autor:
Baek Kim, Hiba Fatayer, Andrew M Hanby, Kieran Horgan, Sarah L Perry, Elizabeth M A Valleley, Eldo T Verghese, Bethany J Williams, James L Thorne, Thomas A Hughes
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62766 (2013)
Three main xenobiotic efflux pumps have been implicated in modulating breast cancer chemotherapy responses. These are P-glycoprotein (Pgp), Multidrug Resistance-associated Protein 1 (MRP1), and Breast Cancer Resistance Protein (BCRP). We investigated
Externí odkaz:
https://doaj.org/article/a6c3d6fdfb254f6e9c85135c94cb5410
Publikováno v:
Case Reports in Surgery, Vol 2013 (2013)
Malignant transformation of endometriosis is rare and is usually seen in ovarian endometriosis. The colon and rectum are the most common sites for extragonadal endometriosis, and although serosal involvement is commonly seen, mucosal involvement is r
Externí odkaz:
https://doaj.org/article/88710a44eefa433f88bf26fd1a16efc7
Autor:
Toral Gathani, Ramsey Cutress, David Dodwell, Kieran Horgan, Cliona Kirwan, Hilary Stobart, Sau Wan Kan, Gillian Reeves, Sian Sweetland
Toral Gathani and colleagues argue that risk stratification by age and sex should be used to help manage demand on breast clinics efficiently to minimise delays in diagnosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63bd80560eeba72ef2ceb1dd87f1e46
https://eprints.soton.ac.uk/477535/
https://eprints.soton.ac.uk/477535/
Autor:
Judith M. Bliss, David A. Cameron, Anthony I. Skene, Jane Ooi, Sankaran Narayanan, Jay Naik, James P. Morden, Stuart A. McIntosh, Sarah E. Miller, Kieran Horgan, Sue M. Hartup, Abigail Evans, Marie A. Emson, David Dodwell, Ramsey I. Cutress, Anne Armstrong, Emad A. Rakha, Abeer M. Shaaban, Andrew Hanby, Angela Cramer, Adrian Murray Brunt, Nuria Porta, Nigel Bundred
Supplementary Data from Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2582b40e3e9fb5fd63904f027e23fca8
https://doi.org/10.1158/1078-0432.22487985
https://doi.org/10.1158/1078-0432.22487985
Autor:
Judith M. Bliss, David A. Cameron, Anthony I. Skene, Jane Ooi, Sankaran Narayanan, Jay Naik, James P. Morden, Stuart A. McIntosh, Sarah E. Miller, Kieran Horgan, Sue M. Hartup, Abigail Evans, Marie A. Emson, David Dodwell, Ramsey I. Cutress, Anne Armstrong, Emad A. Rakha, Abeer M. Shaaban, Andrew Hanby, Angela Cramer, Adrian Murray Brunt, Nuria Porta, Nigel Bundred
Supplementary Figure from Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc8932db29ed31281a0cffa784eab54
https://doi.org/10.1158/1078-0432.22487964
https://doi.org/10.1158/1078-0432.22487964
Autor:
Julia M.W. Gee, Andrew Foxley, Pauline Finlay, Rahul Deb, Gaia Schiavon, Paul Rugman, Martin Pass, Justin P.O. Lindemann, Loumpiana Koulai, Elza C. de Bruin, Marie Cullberg, S.Y. Amy Cheung, Roberta Littleford, Petra Rauchhaus, Kieran Horgan, Ali Jahan, Samreen Ahmed, Daniel Rea, Anthony Skene, Chris Holcombe, Abigail Evans, Kwok-Leung Cheung, Robert E. Coleman, John F.R. Robertson
Purpose:The STAKT study examined short-term exposure (4.5 days) to the oral selective pan-AKT inhibitor capivasertib (AZD5363) to determine if this drug can reach its therapeutic target in sufficient concentration to significantly modulate key biomar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ce4aaa6b32841a0165d4e23b5bbbdf
https://doi.org/10.1158/1078-0432.c.6530157.v1
https://doi.org/10.1158/1078-0432.c.6530157.v1