Zobrazeno 1 - 10
of 399
pro vyhledávání: '"Kieran Clarke"'
Autor:
Oscar Seira, HyoJoon (David) Park, Jie Liu, Michelle Poovathukaran, Kieran Clarke, Robert Boushel, Wolfram Tetzlaff
Publikováno v:
Cells, Vol 13, Iss 21, p 1746 (2024)
Spinal cord injury (SCI) pathology and pathophysiology can be attributed to both primary physical injury and secondary injury cascades. Secondary injury cascades involve dysregulated metabolism and energetic deficits directly linked to compromised mi
Externí odkaz:
https://doaj.org/article/e1049736732244e7af5c91c542b54bf7
Autor:
Oscar Seira, Hyojoon Park, Jie Liu, Michelle Poovathukaran, Kieran Clarke, Robert Boushel, Wolfram Tetzlaff
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S202-S203 (2023)
Externí odkaz:
https://doaj.org/article/33aef257fb4347c882f915d27287149c
Autor:
Matthew C. Frise, David A. Holdsworth, Andrew W. Johnson, Yu Jin Chung, M. Kate Curtis, Pete J. Cox, Kieran Clarke, Damian J. Tyler, David J. Roberts, Peter J. Ratcliffe, Keith L. Dorrington, Peter A. Robbins
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Iron deficiency impairs skeletal muscle metabolism. The underlying mechanisms are incompletely characterised, but animal and human experiments suggest the involvement of signalling pathways co-dependent upon oxygen and iron availability, inc
Externí odkaz:
https://doaj.org/article/02103a8a32c048e69a723768ec05c297
Autor:
David J. Dearlove, Adrian Soto Mota, David Hauton, Katherine Pinnick, Rhys Evans, Jack Miller, Roman Fischer, James S.O. Mccullagh, Leanne Hodson, Kieran Clarke, Pete J. Cox
Publikováno v:
Physiological Reports, Vol 10, Iss 10, Pp n/a-n/a (2022)
Abstract Elevating blood ketones may enhance exercise capacity and modulate adaptations to exercise training; however, these effects may depend on whether hyperketonemia is induced endogenously through dietary carbohydrate restriction, or exogenously
Externí odkaz:
https://doaj.org/article/7a777fd4aa2146328978690cbd5a20da
Publikováno v:
Endocrinology, Diabetes & Metabolism, Vol 5, Iss 1, Pp n/a-n/a (2022)
Abstract Background Interventions that induce ketosis simultaneously lower blood glucose and the explanation for this phenomenon is unknown. Additionally, the glucose‐lowering effect of acute ketosis is greater in people with type 2 diabetes (T2D).
Externí odkaz:
https://doaj.org/article/bfea8b403afa44e2b4cd940764e71df1
Autor:
Donnie Cameron, Adrian Soto-Mota, David R. Willis, Jane Ellis, Nathan E. K. Procter, Richard Greenwood, Neil Saunders, Rolf F. Schulte, Vassilios S. Vassiliou, Damian J. Tyler, Albrecht Ingo Schmid, Christopher T. Rodgers, Paul N. Malcolm, Kieran Clarke, Michael P. Frenneaux, Ladislav Valkovič
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
In this acute intervention study, we investigated the potential benefit of ketone supplementation in humans by studying cardiac phosphocreatine to adenosine-triphosphate ratios (PCr/ATP) and skeletal muscle PCr recovery using phosphorus magnetic reso
Externí odkaz:
https://doaj.org/article/0aa98c2f320e495f9d9b0c3c085e257a
Autor:
David J. Dearlove, David Holdsworth, Tom Kirk, Leanne Hodson, Evelina Charidemou, Eline Kvalheim, Brianna Stubbs, Andrew Beevers, Julian L. Griffin, Rhys Evans, Jeremy Robertson, Kieran Clarke, Pete J. Cox
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Purpose: In this study, we determined ketone oxidation rates in athletes under metabolic conditions of high and low carbohydrate (CHO) and fat availability.Methods: Six healthy male athletes completed 1 h of bicycle ergometer exercise at 75% maximal
Externí odkaz:
https://doaj.org/article/dd2f871937a8411faa7c40ffdb2f3746
Autor:
Matthew C. Frise, David A. Holdsworth, Andrew W. Johnson, Yu Jin Chung, M. Kate Curtis, Pete J. Cox, Kieran Clarke, Damian J. Tyler, David J. Roberts, Peter J. Ratcliffe, Keith L. Dorrington, Peter A. Robbins
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/5fd6d84b073f4868bfa0e011f96222a9
Autor:
Khadijeh Kathy Pakzad, Jun Jie Tan, Stephanie Anderson, Mary Board, Kieran Clarke, Carolyn A. Carr
Publikováno v:
Stem Cell Research, Vol 54, Iss , Pp 102422- (2021)
Cardiosphere-derived cells (CDCs) can be expanded in vitro and induced to differentiate along the cardiac lineage. To recapitulate the phenotype of an adult cardiomyocyte, differentiating progenitors need to upregulate mitochondrial glucose and fatty
Externí odkaz:
https://doaj.org/article/f0ec3124754045e0a60432db138d9e0e
Publikováno v:
Endocrinology, Diabetes & Metabolism, Vol 4, Iss 3, Pp n/a-n/a (2021)
Abstract Introduction Ketogenic diets have shown to improve glycaemic control in patients with type 2 diabetes. This study investigated the safety, tolerability, and effects on glycaemic control in patients with type 2 diabetes of an exogenous ketone
Externí odkaz:
https://doaj.org/article/674625e9d0134c78bda58c3bb671aab4