HIV-1 and SIV Predominantly Use CCR5 Expressed on a Precursor Population to Establish Infection in T Follicular Helper Cells

Autor: John Zaunders, Yin Xu, Chansavath Phetsouphanh, Kazuo Suzuki, Anu Aggrawal, Stephanie Graff-Dubois, Michael Roche, Michelle Bailey, Sheilajen Alcantara, Kieran Cashin, Rahuram Sivasubramaniam, Kersten K. Koelsch, Brigitte Autran, Richard Harvey, Paul R. Gorry, Arnaud Moris, David A. Cooper, Stuart Turville, Stephen J. Kent, Anthony D. Kelleher

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

BackgroundT follicular helper (Tfh) cells are increasingly recognized as a major reservoir of HIV infection that will likely need to be addressed in approaches to curing HIV. However, Tfh express minimal CCR5, the major coreceptor for HIV-1, and the

Externí odkaz: https://doaj.org/article/0c923328b7194c45b8edb0c1659f54d1

Covariance of charged amino acids at positions 322 and 440 of HIV-1 Env contributes to coreceptor specificity of subtype B viruses, and can be used to improve the performance of V3 sequence-based coreceptor usage prediction algorithms.

Autor: Kieran Cashin, Jasminka Sterjovski, Katherine L Harvey, Paul A Ramsland, Melissa J Churchill, Paul R Gorry

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109771 (2014)

The ability to determine coreceptor usage of patient-derived human immunodeficiency virus type 1 (HIV-1) strains is clinically important, particularly for the administration of the CCR5 antagonist maraviroc. The envelope glycoprotein (Env) determinan

Externí odkaz: https://doaj.org/article/4286cc87351a4327acfdf16c2e6e080d

CXCR4-Using HIV Strains Predominate in Naive and Central Memory CD4+ T Cells in People Living with HIV on Antiretroviral Therapy: Implications for How Latency Is Established and Maintained

Autor: Jori Symons, Melissa J Churchill, Paul U. Cameron, Carolin Tumpach, Steven G. Deeks, Jenny L. Anderson, Paul R Gorry, Sharon R Lewin, Gabriela Khoury, Michael Roche, Matthew J. Gartner, Kieran Cashin

Publikováno v: Journal of virology, vol 94, iss 6
J Virol

HIV can persist in people living with HIV (PLWH) on antiretroviral therapy (ART) in multiple CD4(+) T cell subsets, including naive cells, central memory (CM) cells, transitional (TM) cells, and effector memory (EM) cells. Since these cells express d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ec69fee67fc0ae79bce23cc0f09d32
https://escholarship.org/uc/item/83n3r035

Quantifying Susceptibility of CD4+ Stem Memory T-Cells to Infection by Laboratory Adapted and Clinical HIV-1 Strains

Autor: Michael Roche, Kieran Cashin, Anne Ellett, Martin R. Jakobsen, Melissa J Churchill, Jacqueline K. Flynn, Paul R Gorry, Katharina Borm, Geza Paukovics

Publikováno v: Viruses, Vol 6, Iss 2, Pp 709-726 (2014)
Flynn, J K, Paukovics, G, Cashin, K, Borm, K, Ellett, A, Roche, M, Jakobsen, M R, Churchill, M J & Gorry, P R 2014, ' Quantifying Susceptibility of CD4+ Stem Memory T-Cells to Infection by Laboratory Adapted and Clinical HIV-1 Strains ', Viruses, vol. 6, no. 2, pp. 709-26 . https://doi.org/10.3390/v6020709
Viruses; Volume 6; Issue 2; Pages: 709-726
Viruses

CD4+ T cells are principal targets for human immunodeficiency virus type 1 (HIV-1) infection. CD4+ T cell subsets are heterogeneous cell populations, divided by functional and phenotypic differences into naïve and memory T cells. The memory CD4+ T c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedc6b9948d39c09fdcd59731f4a91e3
https://doi.org/10.3390/v6020709

Reliable Genotypic Tropism Tests for the Major HIV-1 Subtypes

Autor: Michael Roche, Melissa J Churchill, Jasminka Sterjovski, Danielle Perez-Bercoff, Lachlan Robert Gray, Guinevere Q. Lee, Katherine L. Harvey, Paul R Gorry, P. Richard Harrigan, Kieran Cashin, Fraser Drummond, James F. Demarest

Publikováno v: Scientific Reports

Over the past decade antiretroviral drugs have dramatically improved the prognosis for HIV-1 infected individuals, yet achieving better access to vulnerable populations remains a challenge. The principal obstacle to the CCR5-antagonist, maraviroc, fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9e438a881a9e89157a6ef30154b118
http://europepmc.org/articles/PMC4894445