Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kieran Brune"'
Autor:
Douglas N. Robinson, Nadia N. Hansel, Vasudha Srivastava, Wanda K. O'Neal, Menghan Wang, Nirupama Putcha, Kieran Brune, M. Bradley Drummond, Hong Lam, Pooja Mandke, Danny Shade, Venkataramana K. Sidhaye, Steven S. An, Kristine Nishida
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Cigarette smoke (CS) drives disease development and progression. The epithelial barrier is damaged by CS with increased monolayer permeability. However, the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ad55179e85ddee6b8efd3945d67c82
https://europepmc.org/articles/PMC5625260/
https://europepmc.org/articles/PMC5625260/
Autor:
Kieran Brune, Ralph H. Hruban, Emily Palmisano, Marcia I. Canto, Alison P. Klein, Michael Goggins, Bryan Lau
Publikováno v:
JNCI Journal of the National Cancer Institute
Background Young-onset cancer is a hallmark of many familial cancer syndromes, yet the implications of young-onset disease in predicting risk of pancreatic cancer among familial pancreatic cancer (FPC) kindred members remain unclear. Methods To under
Autor:
Hiroyuki Matsubayashi, Noriyoshi Fukushima, C. D. Boehm, Gloria M. Petersen, Tadayoshi Abe, Kieran Brune, Norihiro Sato, Ralph H. Hruban, Michael Goggins, Marcia I. Canto
Publikováno v:
Clinical Cancer Research. 13:6019-6025
Purpose: Most familial cancer susceptibility genes are tumor suppressor genes that are biallelically inactivated in familial neoplasms through somatic deletion of the wild-type allele. Identifying the genomic losses that occur in pancreatic neoplasms
Autor:
Michael Goggins, Kieran Brune, Elliot K. Fishman, Kyoichi Takaori, Ralph H. Hruban, Marcia I. Canto, Scott E. Kern, Kurtis A. Campbell
Publikováno v:
Journal of Hepato-Biliary-Pancreatic Surgery. 14:255-263
Three distinct noninvasive precursor lesions to invasive ductal adenocarcinoma of the pancreas have been described. These include the mucinous cystic neoplasm, intraductal papillary mucinous neoplasm, and pancreatic intraepithelial neoplasia. The ear
Autor:
Constance A. Griffin, Charles J. Yeo, Michael Goggins, Anthony N. Kalloo, Jeffrey M. Richman, E K Fishman, Jennifer E. Axilbund, Ralph H. Hruban, Syed Z. Ali, Sanjay B. Jagannath, Marcia I. Canto, Gloria M. Petersen, Sergey V. Kantsevoy, Francis M. Giardiello, Kieran Brune
Publikováno v:
Clinical Gastroenterology and Hepatology. 4:766-781
Background & Aims: Individuals with a strong family history of pancreatic cancer and persons with Peutz-Jeghers syndrome (PJS) have an increased risk for pancreatic cancer. This study screened for early pancreatic neoplasia and compared the pancreati
Autor:
Venkataramana K. Sidhaye, Kieran Brune, James A. Frank, Andreas Schwingshackl, James H. Finigan
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 308(8)
The pulmonary epithelium serves as a barrier to prevent access of the inspired luminal contents to the subepithelium. In addition, the epithelium dictates the initial responses of the lung to both infectious and noninfectious stimuli. One mechanism b
Autor:
Kieran Brune, Lori Wroblewski, Jennifer E. Axilbund, Brenda C Brehon, Constance A. Griffin, Marcia I. Canto
Publikováno v:
Hereditary Cancer in Clinical Practice
Hereditary Cancer in Clinical Practice, Vol 3, Iss 3, Pp 115-122 (2005)
Hereditary Cancer in Clinical Practice, Vol 3, Iss 3, Pp 115-122 (2005)
Purpose To assess patient views regarding the value of genetic counselling for familial pancreas cancer in the absence of predictive genetic testing. Patients and methods At-risk adults with three or more relatives with pancreas cancer received genet
Autor:
Charles J. Yeo, S. T. Martin, Juliet Philips, Michael Goggins, Ralph H. Hruban, Scott E. Kern, Carmelle D Rogers, Kieran Brune, Fergus J. Couch, Hiroyuki Matsubayashi
Publikováno v:
Oncogene. 24:3652-3656
Germline BRCA2 mutations predispose to the development of pancreatic cancer. A polymorphic stop codon in the coding region of BRCA2 (K3326X) has been described, and although an initial epidemiological study suggested it was not disease causing, subse
Autor:
Gloria M. Petersen, Kieran Brune, Sanjay B. Jagannath, Ralph H. Hruban, Francis M. Giardiello, Charles J. Yeo, Michael Goggins, Jennifer E. Axilbund, Steven Piantadosi, Syed Z. Ali, Marcia I. Canto, Constance A. Griffin, Elliot K. Fishman
Publikováno v:
Clinical Gastroenterology and Hepatology. 2:606-621
Background & Aims: Relatives of patients with pancreatic cancer and persons with certain inherited syndromes are at increased risk for developing pancreatic cancer. We prospectively evaluated the feasibility of screening for pancreatic neoplasia in h
Autor:
Noriyoshi Fukushima, Norihiro Sato, Scott E. Kern, Kieran Brune, Charles J. Yeo, Michael Goggins, Hiroyuki Matsubayashi, Ralph H. Hruban, Marcia I. Canto
Publikováno v:
Cancer Biology & Therapy. 2:650-653
Long standing chronic pancreatitis is a risk factor for developing pancreatic cancer. Inheritance of polymorphisms in SPINK1 and CFTR are associated with an increased risk of developing pancreatitis. The aim of this study was to determine if patients