Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kiera L Clayton"'
Autor:
Velia Siciliano, Breanna DiAndreth, Blandine Monel, Jacob Beal, Jin Huh, Kiera L Clayton, Liliana Wroblewska, AnneMarie McKeon, Bruce D. Walker, Ron Weiss
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Synthetic biology principles are often used to design circuits that tune gene expression in response to changes in intracellular environments. Here the authors design a modular platform for intracellular protein sensing devices with transcriptional o
Externí odkaz:
https://doaj.org/article/29e185b3e05642a993be2f596425ebc8
Autor:
Glen M Chew, Tsuyoshi Fujita, Gabriela M Webb, Benjamin J Burwitz, Helen L Wu, Jason S Reed, Katherine B Hammond, Kiera L Clayton, Naoto Ishii, Mohamed Abdel-Mohsen, Teri Liegler, Brooks I Mitchell, Frederick M Hecht, Mario Ostrowski, Cecilia M Shikuma, Scott G Hansen, Mark Maurer, Alan J Korman, Steven G Deeks, Jonah B Sacha, Lishomwa C Ndhlovu
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005349 (2016)
HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication. We repo
Externí odkaz:
https://doaj.org/article/98d1b0911eb74042a13b8e84449dee0c
Autor:
Grant C. Weaver, Christine L. Schneider, Aniuska Becerra-Artiles, Kiera L. Clayton, Amy W. Hudson, Lawrence J. Stern
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionHuman Herpesvirus 6B (HHV-6B) impedes host immune responses by downregulating class I MHC molecules (MHC-I), hindering antigen presentation to CD8+ T cells. Downregulation of MHC-I disengages inhibitory receptors on natural killer (NK) ce
Externí odkaz:
https://doaj.org/article/b3e8081e247a4c37bd1498def231db06
Autor:
Feng Yun Yue, Kiera L. Clayton, Chris Zealey, Wenbo Gao, Yuan Bie, Jordan A. Schwartz, Jun Liu, Mario A. Ostrowski, Yu Li, James M. Rini, Patrick Budylowski
Publikováno v:
Vaccine. 38:2149-2159
HIV-1 envelope (Env)-specific antibody present at mucosal surfaces can block entry of HIV-1 into these portals and thus should be elicited by an HIV-1 preventive vaccine. Since three molecules of tumor necrosis factor superfamily (TNFSF), APRIL, BAFF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da75ca9fdbfbbd7c0e5a8cf78f1253f0
https://doi.org/10.1016/j.vaccine.2020.01.050
https://doi.org/10.1016/j.vaccine.2020.01.050
Autor:
Julie Brouchon, Fangfu Ye, Jing Xia, David A. Weitz, John A. Heyman, Kiera L. Clayton, Li Sun, Yuan Yuan, J. Mauricio Calvo-Calle, Xu Zhang
Publikováno v:
Lab Chip
Quantification of cell-secreted molecules, e.g., cytokines, is fundamental to the characterization of immune responses. Cytokine capture assays that use engineered antibodies to anchor the secreted molecules to the secreting cells are widely used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da3dde3c5a0f78cbdbc2371818b8080
https://doi.org/10.1039/c9lc01261c
https://doi.org/10.1039/c9lc01261c
Autor:
Blandine Monel, Jacob Beal, Breanna DiAndreth, Jin Huh, AnneMarie McKeon, Liliana Wroblewska, Velia Siciliano, Bruce D. Walker, Ron Weiss, Kiera L. Clayton
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Nature Communications
Nature
Nature Communications
Nature
Understanding and reshaping cellular behaviors with synthetic gene networks requires the ability to sense and respond to changes in the intracellular environment. Intracellular proteins are involved in almost all cellular processes, and thus can prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390445131a578a1c46571067db1de31e
http://link.springer.com/article/10.1038/s41467-018-03984-5
http://link.springer.com/article/10.1038/s41467-018-03984-5
Autor:
David R. Collins, Josh Lengieza, Farokh Dotiwala, Judy Lieberman, Musie Ghebremichael, Kiera L. Clayton, Bruce D. Walker
Publikováno v:
Nature Immunology. 19:475-486
CD4+ T lymphocytes are the principal target of human immunodeficiency virus (HIV), but infected macrophages also contribute to viral pathogenesis. The killing of infected cells by CD8+ cytotoxic T lymphocytes (CTLs) leads to control of viral replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4c1cbafcaf0d6007aedb26a020b059e
https://doi.org/10.1038/s41590-018-0085-3
https://doi.org/10.1038/s41590-018-0085-3
Autor:
Bruce D. Walker, Hidde L. Ploegh, Geetha H. Mylvaganam, Alonso Villasmil-Ocando, Heather Stuart, Kiera L. Clayton, Marcela V. Maus, Mohammad Rashidian
Publikováno v:
Cell Host Microbe
Summary Natural killer (NK) cells are innate cytolytic effectors that target HIV-infected CD4+ T cells. In conjunction with antibodies recognizing the HIV envelope, NK cells also eliminate HIV-infected targets through antibody-dependent cellular cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c130e4da009c13692542f4d7281d36dc
https://doi.org/10.1016/j.chom.2021.01.006
https://doi.org/10.1016/j.chom.2021.01.006
Autor:
Kiera L. Clayton, Mario M. Ostrowski
Publikováno v:
Journal of Leukocyte Biology. 102:1286-1288
Discussion on the role of sTim-3 in innate and adaptive immune responses during system lupus erythematous and pathogenic diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f6063686b07706a814a387a6c703b4
https://doi.org/10.1189/jlb.3ce0717-279rr
https://doi.org/10.1189/jlb.3ce0717-279rr
Autor:
A. K. M. Nur-ur Rahman, Lishomwa C. Ndhlovu, Mario A. Ostrowski, Marion C. Lanteri, Steven G. Deeks, Matthew Douglas-Vail, Glen M. Chew, Philip J. Norris, Kiera L. Clayton, Irene Y. Xie, Ravi Tandon, Karyn E. Medcalf
Publikováno v:
Journal of virology, vol 89, iss 7
Chronic HIV infection results in a loss of HIV-specific CD8 + T cell effector function, termed “exhaustion,” which is mediated, in part, by the membrane coinhibitory receptor T cell immunoglobulin mucin domain-3 (Tim-3). Like many other receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b55a65bc648ad7c0bc3cebea30d43d
https://doi.org/10.1128/jvi.00006-15
https://doi.org/10.1128/jvi.00006-15