Mononuclear cell composition and activation in blood and mucosal tissue of eosinophilic esophagitis.

Autor: Gruden E; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Kienzl M; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Ristic D; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Kindler O; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Kaspret DM; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Schmid ST; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Kargl J; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Sturm E; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Doyle AD; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, AZ, United States., Wright BL; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, AZ, United States., Baumann-Durchschein F; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Konrad J; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Blesl A; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Schlager H; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Schicho R; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Jan 22; Vol. 15, pp. 1347259. Date of Electronic Publication: 2024 Jan 22 (Print Publication: 2024).

Altered Treg Infiltration after Discoidin Domain Receptor 1 (DDR1) Inhibition and Knockout Promotes Tumor Growth in Lung Adenocarcinoma.

Autor: Maitz K; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria., Valadez-Cosmes P; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria., Raftopoulou S; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria., Kindler O; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria., Kienzl M; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria., Bolouri H; Center for Systems Immunology, Benaroya Research Center, Seattle, WA 98101, USA.; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Houghton AM; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 98195, USA., Schicho R; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.; BioTechMed, 8010 Graz, Austria., Heinemann A; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.; BioTechMed, 8010 Graz, Austria., Kargl J; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.; BioTechMed, 8010 Graz, Austria.

Publikováno v: Cancers [Cancers (Basel)] 2023 Dec 08; Vol. 15 (24). Date of Electronic Publication: 2023 Dec 08.

Tumor microenvironment-derived monoacylglycerol lipase provokes tumor-specific immune responses and lipid profiles.

Autor: Gruden E; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria., Kienzl M; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria. Electronic address: melanie.kienzl@medunigraz.at., Hasenoehrl C; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria., Sarsembayeva A; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria., Ristic D; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria., Schmid ST; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria., Maitz K; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria., Taschler U; Institute of Molecular Biosciences, University of Graz, Graz, Austria., Hahnefeld L; Institute of Clinical Pharmacology, Goethe University, 60590 Frankfurt/Main, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany., Gurke R; Institute of Clinical Pharmacology, Goethe University, 60590 Frankfurt/Main, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany., Thomas D; Institute of Clinical Pharmacology, Goethe University, 60590 Frankfurt/Main, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany., Kargl J; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria., Schicho R; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria.

Publikováno v: Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2023 Sep; Vol. 196, pp. 102585. Date of Electronic Publication: 2023 Aug 09.

Eosinophils promote effector functions of lung group 2 innate lymphoid cells in allergic airway inflammation in mice.

Autor: LeSuer WE; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz., Kienzl M; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Ochkur SI; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz., Schicho R; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Doyle AD; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz., Wright BL; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz; Division of Pulmonology, Phoenix Children's Hospital, Phoenix, Ariz., Rank MA; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz; Division of Pulmonology, Phoenix Children's Hospital, Phoenix, Ariz., Krupnick AS; Department of Surgery, University of Maryland, Baltimore, Md., Kita H; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz; Department of Immunology, Mayo Clinic Arizona, Scottsdale, Ariz., Jacobsen EA; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, Ariz; Department of Immunology, Mayo Clinic Arizona, Scottsdale, Ariz. Electronic address: jacobsen.elizabeth@mayo.edu.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2023 Aug; Vol. 152 (2), pp. 469-485.e10. Date of Electronic Publication: 2023 Apr 06.

Cannabinoid receptor 2 plays a pro-tumorigenic role in non-small cell lung cancer by limiting anti-tumor activity of CD8 ⁺ T and NK cells.

Autor: Sarsembayeva A; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Kienzl M; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Gruden E; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Ristic D; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Maitz K; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Valadez-Cosmes P; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Santiso A; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Hasenoehrl C; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Brcic L; Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria., Lindenmann J; Division of Thoracic and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, Graz, Austria., Kargl J; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Schicho R; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.; BioTechMed, Graz, Austria.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Jan 09; Vol. 13, pp. 997115. Date of Electronic Publication: 2023 Jan 09 (Print Publication: 2022).