A highly conserved tRNA modification contributes to C. albicans filamentation and virulence.

Autor: Böttcher B; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.; Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany., Kienast SD; Max Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.; Research Group for Cellular RNA Biochemistry, Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland., Leufken J; Max Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.; Research Group for Cellular RNA Biochemistry, Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland., Eggers C; Max Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.; Research Group for Cellular RNA Biochemistry, Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland., Sharma P; Max Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.; Research Group for Cellular RNA Biochemistry, Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland., Leufken CM; Max Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Morgner B; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany., Drexler HCA; Bioanalytical Mass Spectrometry Unit, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Schulz D; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany., Allert S; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany., Jacobsen ID; Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.; Institute of Microbiology, Friedrich Schiller University, Jena, Germany., Vylkova S; Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany., Leidel SA; Max Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.; Research Group for Cellular RNA Biochemistry, Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland., Brunke S; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.

Publikováno v: Microbiology spectrum [Microbiol Spectr] 2024 May 02; Vol. 12 (5), pp. e0425522. Date of Electronic Publication: 2024 Apr 08.

Modulation of Escherichia coli Translation by the Specific Inactivation of tRNA ^Gly Under Oxidative Stress.

Autor: Leiva LE; Programa de Biología Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile., Pincheira A; Programa de Biología Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile., Elgamal S; Department of Microbiology and The Center for RNA Biology, The Ohio State University, Columbus, OH, United States., Kienast SD; Max Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.; Cells-in-Motion Cluster of Excellence and Faculty of Medicine, University of Münster, Münster, Germany.; Research Group for RNA Biochemistry, Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland., Bravo V; Unidad de Microbiología, Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago, Chile., Leufken J; Max Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.; Cells-in-Motion Cluster of Excellence and Faculty of Medicine, University of Münster, Münster, Germany.; Research Group for RNA Biochemistry, Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland., Gutiérrez D; Programa de Biología Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile., Leidel SA; Max Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.; Cells-in-Motion Cluster of Excellence and Faculty of Medicine, University of Münster, Münster, Germany.; Research Group for RNA Biochemistry, Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland., Ibba M; Department of Microbiology and The Center for RNA Biology, The Ohio State University, Columbus, OH, United States., Katz A; Programa de Biología Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Publikováno v: Frontiers in genetics [Front Genet] 2020 Aug 18; Vol. 11, pp. 856. Date of Electronic Publication: 2020 Aug 18 (Print Publication: 2020).

Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.

Autor: Braun DA; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Rao J; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Mollet G; Laboratory of Hereditary Kidney Diseases, INSERM UMR1163, Imagine Institute, Paris, France.; Université Paris Descartes-Sorbonne Paris Cité, Imagine Institute, Paris, France., Schapiro D; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Daugeron MC; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France., Tan W; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Gribouval O; Laboratory of Hereditary Kidney Diseases, INSERM UMR1163, Imagine Institute, Paris, France.; Université Paris Descartes-Sorbonne Paris Cité, Imagine Institute, Paris, France., Boyer O; Laboratory of Hereditary Kidney Diseases, INSERM UMR1163, Imagine Institute, Paris, France.; Université Paris Descartes-Sorbonne Paris Cité, Imagine Institute, Paris, France.; Department of Pediatric Nephrology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Revy P; Université Paris Descartes-Sorbonne Paris Cité, Imagine Institute, Paris, France.; INSERM, U1163, Imagine Institute, Laboratory of Genome Dynamics in the Immune system, Paris, France., Jobst-Schwan T; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Schmidt JM; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Lawson JA; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Schanze D; Institute of Human Genetics, University Hospital Magdeburg, Magdeburg, Germany., Ashraf S; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Ullmann JFP; Epilepsy Genetics Program and F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA., Hoogstraten CA; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Boddaert N; Université Paris Descartes-Sorbonne Paris Cité, Imagine Institute, Paris, France.; INSERM, U1163, Imagine Institute, Laboratory of Molecular and Pathophysiological Bases of Cognitive Disorders, and INSERM U1000, Paris, France.; Department of Pediatric Radiology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Collinet B; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France.; Sorbonne Universités UPMC, UFR 927, Sciences de la Vie, Paris, France.; Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie UMR 7590, Sorbonne Universités, UPMC, Université Paris 06, Paris, France., Martin G; Laboratory of Hereditary Kidney Diseases, INSERM UMR1163, Imagine Institute, Paris, France.; Université Paris Descartes-Sorbonne Paris Cité, Imagine Institute, Paris, France., Liger D; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France., Lovric S; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Furlano M; Laboratory of Hereditary Kidney Diseases, INSERM UMR1163, Imagine Institute, Paris, France.; Université Paris Descartes-Sorbonne Paris Cité, Imagine Institute, Paris, France.; Nephrology Department, Fundació Puigvert, IIB Sant Pau, Universitat Autònoma de Barcelona and REDINREN, Barcelona, Spain., Guerrera IC; Proteomics platform 3P5-Necker, Université Paris Descartes-Structure Fédérative de Recherche Necker, INSERM US24/CNRS UMS3633, Paris, France., Sanchez-Ferras O; Goodman Cancer Research Centre and Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Hu JF; Departments of Chemistry and Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Boschat AC; Mass Spectrometry Platform, Imagine Institute, Paris, France., Sanquer S; Department of Metabolomic and Proteomic Biochemistry, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.; INSERM UMR-S1124, Paris Descartes-Sorbonne Paris Cité University, Paris, France., Menten B; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium., Vergult S; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium., De Rocker N; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium., Airik M; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Hermle T; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Shril S; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Widmeier E; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, Renal Division, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Gee HY; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea., Choi WI; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Sadowski CE; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Pabst WL; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Warejko JK; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Daga A; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Basta T; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France., Matejas V; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Scharmann K; Max Planck Institute for Molecular Biomedicine, Muenster, Germany.; Cells-in-Motion Cluster of Excellence, University of Muenster, Muenster, Germany., Kienast SD; Max Planck Institute for Molecular Biomedicine, Muenster, Germany.; Cells-in-Motion Cluster of Excellence, University of Muenster, Muenster, Germany., Behnam B; Department of Medical Genetics and Molecular Biology, Iran University of Medical Sciences (IUMS), Tehran, Iran.; Medical Genetics Branch, National Human Genome Research Institute (NHGRI), Undiagnosed Diseases Program, Common Fund, Office of the Director, National Institutes of Health, Bethesda, Maryland, USA., Beeson B; Department of Diagnostic Imaging, Princess Margaret and King Edward Memorial Hospitals, Perth, Western Australia, Australia., Begtrup A; GeneDx, Gaithersburg, Maryland, USA., Bruce M; Department of Diagnostic Imaging, Princess Margaret and King Edward Memorial Hospitals, Perth, Western Australia, Australia., Ch'ng GS; Department of Genetics, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia., Lin SP; Department of Pediatric Genetics, MacKay Children's Hospital, Taipei, Taiwan.; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan., Chang JH; Department of Pediatrics, MacKay Children's Hospital, Taipei, Taiwan., Chen CH; Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan., Cho MT; GeneDx, Gaithersburg, Maryland, USA., Gaffney PM; Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA., Gipson PE; Internal Medicine and Pediatrics Divisions of Adult and Pediatric Nephrology, University of Michigan, Ann Arbor, Michigan, USA., Hsu CH; Department of Pediatrics, MacKay Children's Hospital, Taipei, Taiwan., Kari JA; Pediatric Nephrology Center of Excellence and Pediatric Department, King Abdulaziz University, Jeddah, Saudi Arabia., Ke YY; Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan., Kiraly-Borri C; Genetic Services of Western Australia, Princess Margaret Hospital for Children and King Edward Memorial Hospital for Women, Subiaco, Western Australia, Australia., Lai WM; Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong, China., Lemyre E; Service de Génétique Médicale, Département de Pédiatrie, CHU Sainte-Justine, Université de Montréal, Montréal, Québec, Canada., Littlejohn RO; Department of Pediatrics, Baylor College of Medicine, San Antonio, Texas, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA., Masri A; Department of Pediatrics, Division of Child Neurology, Faculty of Medicine, University of Jordan, Amman, Jordan., Moghtaderi M; Chronic Kidney Disease Research Center, Tehran University of Medical Science, Tehran, Iran., Nakamura K; Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan., Ozaltin F; Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Hacettepe University, Ankara, Turkey.; Nephrogenetics Laboratory, Hacettepe University Faculty of Medicine, Hacettepe University, Ankara, Turkey.; Hacettepe University Center for Biobanking and Genomics, Hacettepe University, Ankara, Turkey., Praet M; Department of Pathology, Ghent University Hospital, Ghent, Belgium., Prasad C; Department of Genetics, Metabolism and Pediatrics, Western University, London Health Sciences Centre, London, Ontario, Canada., Prytula A; Department of Pediatrics, Ghent University Hospital, Ghent, Belgium., Roeder ER; Department of Pediatrics, Baylor College of Medicine, San Antonio, Texas, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA., Rump P; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Schnur RE; GeneDx, Gaithersburg, Maryland, USA., Shiihara T; Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan., Sinha MD; Department of Paediatric Nephrology, Kings College London, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK., Soliman NA; Department of Pediatrics, Center of Pediatric Nephrology &Transplantation, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt.; Egyptian Group for Orphan Renal Diseases, Cairo, Egypt., Soulami K; Department of Nephrology, Ibn Rochd University Hospital, Casablanca, Morocco., Sweetser DA; Division of Medical Genetics, Massachusetts General Hospital for Children, Boston, Massachusetts, USA., Tsai WH; Division of Genetics and Metabolism, Department of Pediatrics, Chi Mei Medical Center, Tainan, Taiwan., Tsai JD; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.; Department of Pediatrics, MacKay Children's Hospital, Taipei, Taiwan.; Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan.; Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Topaloglu R; Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Hacettepe University, Ankara, Turkey., Vester U; Department of Pediatrics II, University Hospital Essen, Essen, Germany., Viskochil DH; Department of Pediatrics, Division of Medical Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA., Vatanavicharn N; Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Waxler JL; Division of Medical Genetics, Massachusetts General Hospital for Children, Boston, Massachusetts, USA., Wierenga KJ; Department of Pediatrics, Oklahoma University Health Sciences Center (OUHSC), Oklahoma City, Oklahoma, USA., Wolf MTF; Division of Pediatric Nephrology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Wong SN; Department of Pediatrics and Adolescent Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong, China., Leidel SA; Max Planck Institute for Molecular Biomedicine, Muenster, Germany.; Cells-in-Motion Cluster of Excellence, University of Muenster, Muenster, Germany.; Medical Faculty, University of Muenster, Muenster, Germany., Truglio G; Epilepsy Genetics Program and F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Boston, Massachusetts, USA., Dedon PC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Singapore-MIT Alliance for Research and Technology, Infectious Disease IRG, Singapore., Poduri A; Epilepsy Genetics Program and F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA., Mane S; Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA., Lifton RP; Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.; Laboratory of Human Genetics and Genomics, The Rockefeller University, New York, New York, USA., Bouchard M; Goodman Cancer Research Centre and Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Kannu P; Department of Pediatrics, Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Chitayat D; Department of Pediatrics, Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Magen D; Pediatric Nephrology Institute, Rambam Health Care Campus, Haifa, Israel., Callewaert B; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium., van Tilbeurgh H; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France., Zenker M; Institute of Human Genetics, University Hospital Magdeburg, Magdeburg, Germany., Antignac C; Laboratory of Hereditary Kidney Diseases, INSERM UMR1163, Imagine Institute, Paris, France.; Université Paris Descartes-Sorbonne Paris Cité, Imagine Institute, Paris, France.; Department of Genetics, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Hildebrandt F; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: Nature genetics [Nat Genet] 2017 Oct; Vol. 49 (10), pp. 1529-1538. Date of Electronic Publication: 2017 Aug 14.