Zobrazeno 1 - 10
of 340
pro vyhledávání: '"Kielkowski P"'
Autor:
Andreas Wiest, Pavel Kielkowski
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2323-2341 (2024)
Identification of interactions between proteins and natural products or similar active small molecules is crucial for understanding of their mechanism of action on a molecular level. To search elusive, often labile, and low-abundant conjugates betwee
Externí odkaz:
https://doaj.org/article/a23f01df37664466ab7e0d767cecb727
Autor:
Andrea Forero, Fabrizia Pipicelli, Sylvain Moser, Natalia Baumann, Christian Grätz, Mariano Gonzalez Pisfil, Michael W. Pfaffl, Benno Pütz, Pavel Kielkowski, Filippo M. Cernilogar, Giuseppina Maccarrone, Rossella Di Giaimo, Silvia Cappello
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114755- (2024)
Summary: Cellular crosstalk is an essential process influenced by numerous factors, including secreted vesicles that transfer nucleic acids, lipids, and proteins between cells. Extracellular vesicles (EVs) have been the center of many studies focusin
Externí odkaz:
https://doaj.org/article/7d4ae26e23084530b50fdc23ad49390f
Akademický článek
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Akademický článek
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Autor:
K. E. Blethen, S. A. Sprowls, T. A. Arsiwala, C. P. Wolford, D. M. Panchal, R. A. Fladeland, M. J. Glass, L. P. Dykstra, B. N. Kielkowski, J. R. Blackburn, C. J. Andrick, P. R. Lockman
Publikováno v:
Radiation Oncology, Vol 18, Iss 1, Pp 1-10 (2023)
Abstract Background Approximately 20% of all cancer patients will develop brain metastases in their lifespan. The standard of care for patients with multiple brain metastases is whole-brain radiation therapy, which disrupts the blood–brain barrier.
Externí odkaz:
https://doaj.org/article/7f08f2d0d5344a3e825d1f58f3ee88b2
Autor:
Tasneem A. Arsiwala, Samuel A. Sprowls, Kathryn E. Blethen, Ross A. Fladeland, Cullen P. Wolford, Brooke N. Kielkowski, Morgan J. Glass, Peng Wang, Olivia Wilson, Jeffrey S. Carpenter, Manish Ranjan, Victor Finomore, Ali Rezai, Paul R. Lockman
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Background Systemic drug delivery to the central nervous system is limited by presence of the blood–brain barrier (BBB). Low intensity focused ultrasound (LiFUS) is a non-invasive technique to disrupt the BBB, though there is a lack of und
Externí odkaz:
https://doaj.org/article/ba4277831ec64d7eb08e3d7f77c1ff57
Autor:
Tasneem A. Arsiwala, Kathryn E. Blethen, Cullen P. Wolford, Dhruvi M. Panchal, Samuel A. Sprowls, Ross A. Fladeland, Brooke N. Kielkowski, Trenton A. Pritt, Peng Wang, Olivia Wilson, Jeffrey S. Carpenter, Victor Finomore, Ali Rezai, Paul R. Lockman
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Patients with metastatic breast cancer have high and continually increasing rates of brain metastases. During the course of the disease, brain metastases can occur in up to 30% of these patients. In most cases, brain metastases are diagnosed after si
Externí odkaz:
https://doaj.org/article/773747cdbf62440fa2b2e84f5e8746f5
Akademický článek
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Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
Autor:
Christina Kyrousi, Adam C. O’Neill, Agnieska Brazovskaja, Zhisong He, Pavel Kielkowski, Laure Coquand, Rossella Di Giaimo, Pierpaolo D’ Andrea, Alexander Belka, Andrea Forero Echeverry, Davide Mei, Matteo Lenge, Cristiana Cruceanu, Isabel Y. Buchsbaum, Shahryar Khattak, Guimiot Fabien, Elisabeth Binder, Frances Elmslie, Renzo Guerrini, Alexandre D. Baffet, Stephan A. Sieber, Barbara Treutlein, Stephen P. Robertson, Silvia Cappello
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Basal progenitors are enriched in gyrencephalic species like humans contributing to neuronal expansion. Here the authors show that LGALS3BP de novo variants are related to reduced cortical complexity and area in humans and that LGALS3BP regulates neu
Externí odkaz:
https://doaj.org/article/8ef84fb2a10e47ca9c3467c7a2d8e981
Autor:
T.A. Arsiwala, S.A. Sprowls, K.E. Blethen, C.E. Adkins, P.A. Saralkar, R.A. Fladeland, W. Pentz, A. Gabriele, B. Kielkowski, R.I. Mehta, P. Wang, J.S. Carpenter, M. Ranjan, U. Najib, A.R. Rezai, P.R. Lockman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 676-691 (2021)
The blood-brain barrier (BBB) is a major anatomical and physiological barrier limiting the passage of drugs into brain. Central nervous system tumors can impair the BBB by changing the tumor microenvironment leading to the formation of a leaky barrie
Externí odkaz:
https://doaj.org/article/db684b022dd044c39988965adcb22a3a