Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kie Yoshida"'
Autor:
Juri Hasegawa, Tetsuya Nagata, Kensuke Ihara, Jun Tanihata, Satoe Ebihara, Kie Yoshida-Tanaka, Mitsugu Yanagidaira, Masahiro Ohara, Asuka Sasaki, Miyu Nakayama, Syunsuke Yamamoto, Takashi Ishii, Rintaro Iwata-Hara, Mitsuru Naito, Kanjiro Miyata, Fumika Sakaue, Takanori Yokota
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The approval of splice-switching oligonucleotides with phosphorodiamidate morpholino oligomers (PMOs) for treating Duchenne muscular dystrophy (DMD) has advanced the field of oligonucleotide therapy. Despite this progress, PMOs encounter cha
Externí odkaz:
https://doaj.org/article/acc57f07774342059f02713bd8b500a9
Autor:
Tatsuhiko Sano, Tetsuya Nagata, Satoe Ebihara, Kie Yoshida-Tanaka, Ayako Nakamura, Asuka Sasaki, Aki Shimozawa, Hideki Mochizuki, Toshiki Uchihara, Masato Hasegawa, Takanori Yokota
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract In Parkinson's disease and other synucleinopathies, fibrillar forms of α-synuclein (aSyn) are hypothesized to structurally convert and pathologize endogenous aSyn, which then propagates through the neural connections, forming Lewy pathologi
Externí odkaz:
https://doaj.org/article/ab3ae3bd3fb0435899aa972613e4bc0b
Autor:
Masahiro Ohara, Tetsuya Nagata, Rintaro Iwata Hara, Kie Yoshida-Tanaka, Nozomi Toide, Kazunori Takagi, Kazuki Sato, Tomoya Takenaka, Masanori Nakakariya, Kenichi Miyata, Yusuke Maeda, Kazuko Toh, Takeshi Wada, Takanori Yokota
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102289- (2024)
Antisense oligonucleotides (ASOs) are a therapeutic modality for incurable diseases. However, systemic injection of gapmer-type ASOs causes class-related toxicities, including prolongation of activated partial thromboplastin time (aPTT) and thrombocy
Externí odkaz:
https://doaj.org/article/5176d0a643e54340ac19b6a63de2cbd4
Autor:
Chunyan Jia, Su Su Lei Mon, Ying Yang, Maho Katsuyama, Kie Yoshida-Tanaka, Tetsuya Nagata, Kotaro Yoshioka, Takanori Yokota
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 182-196 (2023)
Antisense oligonucleotides (ASOs) are promising therapeutics for intractable central nervous system (CNS) diseases. For this clinical application, neurotoxicity is one of the critical limitations. Therefore, an evaluation of this neurotoxicity from a
Externí odkaz:
https://doaj.org/article/5fd83a8809054f899afbaeebed69e590
Autor:
Hidetoshi Kaburagi, Tetsuya Nagata, Mitsuhiro Enomoto, Takashi Hirai, Masaki Ohyagi, Kensuke Ihara, Kie Yoshida-Tanaka, Satoe Ebihara, Ken Asada, Hiroyuki Yokoyama, Atsushi Okawa, Takanori Yokota
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 910-919 (2022)
Neuropathic pain, a heterogeneous condition, affects 7%–10% of the general population. To date, efficacious and safe therapeutic approaches remain limited. Antisense oligonucleotide (ASO) therapy has opened the door to treat spinal muscular atrophy
Externí odkaz:
https://doaj.org/article/22296da924d746c2af59bc6a87710a40
Autor:
Masaki Ohyagi, Tetsuya Nagata, Kensuke Ihara, Kie Yoshida-Tanaka, Rieko Nishi, Haruka Miyata, Aya Abe, Yo Mabuchi, Chihiro Akazawa, Takanori Yokota
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Using gene silencing to regulate lymphocyte function is a promising therapeutic approach for autommunity, inflammation and cancer. Here the authors use a heteroduplex oligonucleotide for improved potency, efficacy and longer retention times.
Externí odkaz:
https://doaj.org/article/4b4fe927fe694d8682d8833aabacf921
Autor:
Tomoko Nishina, Junna Numata, Kazutaka Nishina, Kie Yoshida-Tanaka, Keiko Nitta, Wenying Piao, Rintaro Iwata, Shingo Ito, Hiroya Kuwahara, Takeshi Wada, Hidehiro Mizusawa, Takanori Yokota
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
We developed an efficient system for delivering short interfering RNA (siRNA) to the liver by using α-tocopherol conjugation. The α-tocopherol–conjugated siRNA was effective and safe for RNA interference–mediated gene silencing in vivo. In cont
Externí odkaz:
https://doaj.org/article/720afe85465748c58e97aac4309e7d69
Autor:
Fuying Li, Keiko Ichinose, Satoru Ishibashi, Syunsuke Yamamoto, Eri Iwasawa, Motohiro Suzuki, Kie Yoshida-Tanaka, Kotaro Yoshioka, Tetsuya Nagata, Hideki Hirabayashi, Kaoru Mogushi, Takanori Yokota
Publikováno v:
Molecular Therapy. 31:1106-1122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf7153ffba6f6b47e7139c61ab30d662
https://doi.org/10.1016/j.ymthe.2023.01.016
https://doi.org/10.1016/j.ymthe.2023.01.016
Autor:
Kie Yoshida-Tanaka, Hidetoshi Kaburagi, Kotaro Yoshioka, Naoto Arimura, Takanori Yokota, Frank Rigo, Toshiki Uchihara, Takashi Ishii, Kensuke Ihara, Kenichi Miyata, Haruka Miyata, Takeshi Wada, Kanjiro Miyata, Chrissa A. Dwyer, Punit P. Seth, Tetsuya Nagata, Rintaro Iwata Hara, Syunsuke Yamamoto, Hideki Hirabayashi, Satoe Ebihara, Tomoko Igari, C. Frank Bennett, Masaki Ohyagi, Berit Powers
Publikováno v:
Nature Biotechnology. 39:1529-1536
Achieving regulation of endogenous gene expression in the central nervous system (CNS) with antisense oligonucleotides (ASOs) administered systemically would facilitate the development of ASO-based therapies for neurological diseases. We demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea20dbc680bd2292680a38bb270a82d4
https://doi.org/10.1038/s41587-021-00972-x
https://doi.org/10.1038/s41587-021-00972-x
Autor:
Khongorzul Tsogtsaikhan, Yuka Hatano, Moe Kosaka, Kie Yoshida, Tserenbat Minjuur, Ariuntuul Garidkhuu, Keiichi Sasaki, Toshihiko Suzuki
Publikováno v:
Legal Medicine. 62:102234
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfccbb754e5fd4ae62281cdf1251ff93
https://doi.org/10.1016/j.legalmed.2023.102234
https://doi.org/10.1016/j.legalmed.2023.102234