Výsledky vyhledávání - "Kidney Neoplasms/genetics"

Molecular analysis and favorable clinical outcomes in real-world patients with metastatic renal cell carcinoma

Autor: Frede Donskov, Cathy Anne Pinto, Raluca Predoiu, Claire Fox, Jeanette Baehr Georgsen, Katrine Skaarup, Mehmet Burcu, Rodolfo Perini, Torben Steiniche

Publikováno v: Donskov, F, Pinto, C A, Predoiu, R, Fox, C, Georgsen, J B, Skaarup, K, Burcu, M, Perini, R & Steiniche, T 2022, ' Molecular analysis and favorable clinical outcomes in real-world patients with metastatic renal cell carcinoma ', Acta Oncologica, vol. 61, no. 10, pp. 1268-1277 . https://doi.org/10.1080/0284186X.2022.2119100

BACKGROUND: Prior biomarker studies have mainly been restricted to advanced RCC patients treated in clinical trials or have had limited integration of immunotherapy features such as programmed death ligand (PD-L)-1 with gene expression signatures int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544e13b279d9c7d4b03f0b17b9050b63
https://pubmed.ncbi.nlm.nih.gov/36112410

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Current recommendations for clinical surveillance and genetic testing in rhabdoid tumor predisposition: a report from the SIOPE Host Genome Working Group

Autor: H. Boztug, Uwe Kordes, Christian P. Kratz, Kornelius Kerl, Franck Bourdeaut, K. Jahnukainen, V. Ridola, M. Jorgensen, Iris Kventsel, K. Katsibardi, Karolina Nemes, R. Farah, E. Stutz, M. C. A. Cornips, K. W. Pajtler, Michael C. Frühwald, S. Glentis, D. G. R. Evans, Steffen Hirsch

Publikováno v: Familial Cancer
Frühwald, M C, Nemes, K, Boztug, H, Cornips, M C A, Evans, D G, Farah, R, Glentis, S, Jorgensen, M, Katsibardi, K, Hirsch, S, Jahnukainen, K, Kventsel, I, Kerl, K, Kratz, C P, Pajtler, K W, Kordes, U, Ridola, V, Stutz, E & Bourdeaut, F 2021, ' Current recommendations for clinical surveillance and genetic testing in rhabdoid tumor predisposition : a report from the SIOPE Host Genome Working Group ', Familial Cancer, vol. 20, pp. 305-316 . https://doi.org/10.1007/s10689-021-00229-1

The rhabdoid tumor (RT) predisposition syndromes 1 and 2 (RTPS1 and 2) are rare genetic conditions rendering young children vulnerable to an increased risk of RT, malignant neoplasms affecting the kidney, miscellaneous soft-part tissues, the liver an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb807eb1cf1f37b6b01b7fc71ed9382
https://doi.org/10.1007/s10689-021-00229-1

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TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

Autor: Yvan Larondelle, Charline Degavre, Laurenne Petit, Joao Pedro Santiago de Jesus, Carine Michiels, Chantal Dessy, Bastien Doix, Olivier Feron, Catherine Vander Linden, Céline Guilbaud, Ruben Martherus, Estelle Bastien, Cyril Corbet, Emeline Dierge

Publikováno v: Nature Communications, Vol. 11, no.1, p. 1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications

Acidosis, a common characteristic of the tumor microenvironment, is associated with alterations in metabolic preferences of cancer cells and progression of the disease. Here we identify the TGF-β2 isoform at the interface between these observations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68950cb71c22ec4eb3d334e9c4db980b
https://hdl.handle.net/2078.1/226540

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Exploring the hereditary background of renal cancer in Denmark

Autor: Anne-Marie Gerdes, Karin Wadt, Maria Bejerholm Christensen, Lotte Nylandsted Krogh, Uffe Birk Jensen, Charlotte Kvist Lautrup, Anders Bojesen, Thomas van Overeem Hansen

Publikováno v: Christensen, M B, Wadt, K, Jensen, U B, Lautrup, C K, Bojesen, A, Krogh, L N, van Overeem Hansen, T & Gerdes, A M 2019, ' Exploring the hereditary background of renal cancer in Denmark ', PLOS ONE, vol. 14, no. 4, e0215725 . https://doi.org/10.1371/journal.pone.0215725
PLoS ONE
Christensen, M B, Wadt, K, Jensen, U B, Lautrup, C K, Bojesen, A, Krogh, L N, Overeem Hansen, T V & Gerdes, A-M 2019, ' Exploring the hereditary background of renal cancer in Denmark ', PLoS ONE, vol. 14, no. 4, e0215725 . https://doi.org/10.1371/journal.pone.0215725
Christensen, M B, Wadt, K, Jensen, U B, Lautrup, C K, Bojesen, A, Krogh, L N, Overeem Hansen, T V & Gerdes, A-M 2019, ' Exploring the hereditary background of renal cancer in Denmark ', PLOS ONE, vol. 14, no. 4, e0215725, pp. 1-16 . https://doi.org/10.1371/journal.pone.0215725
Christensen, M B, Wadt, K, Jensen, U B, Lautrup, C K, Bojesen, A, Krogh, L N, Overeem Hansen, T V & Gerdes, A-M 2019, ' Exploring the hereditary background of renal cancer in Denmark ', PLOS ONE, vol. 14, no. 4, e0215725 . https://doi.org/10.1371/journal.pone.0215725
PLoS ONE, Vol 14, Iss 4, p e0215725 (2019)

BACKGROUND: Every year more than 800 patients in Denmark are diagnosed with renal cell carcinoma (RCC) of which 3-5% are expected to be part of a hereditary renal cancer syndrome. We performed genetic screening of causative and putative RCC-genes (VH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65de305f7a1331ad5ebebe9680f07da2
https://pure.au.dk/portal/da/publications/exploring-the-hereditary-background-of-renal-cancer-in-denmark(1c2b74dd-9779-4823-a2eb-95b1a027ea4b).html

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TRIM28 haploinsufficiency predisposes to Wilms tumor

Publikováno v: International Journal of Cancer, 145, 4, pp. 941-951
International Journal of Cancer, 145, 941-951
International Journal of Cancer, 145(4), 941. Wiley-Liss Inc.

Graf, Norbert/0000-0002-2248-323X; Reis, Andre/0000-0002-6301-6363; Diets, Illja/0000-0001-7603-8898; Popp, Bernt/0000-0002-3679-1081; Thiel, Christian T/0000-0003-3817-7277; Roeleveld, Nel/0000-0002-3390-4466; Reis, AlessanRSS/0000-0001-8486-7469; V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7b87a0f678c336c2af58b01b299313
https://doi.org/10.1002/ijc.32167

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Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene

Autor: Peter J. Ratcliffe, Edison T. Liu, Charles C. Wykoff, Patrick H. Maxwell, M E Cockman, Christos Sotiriou, Adrian L. Harris

Publikováno v: British Journal of Cancer
British Journal of Cancer, 90 (6

Gene expression analysis was performed on a human renal cancer cell line (786-0) with mutated VHL gene and a transfectant with wild-type VHL to analyse genes regulated by VHL and to compare with the gene programme regulated by hypoxia. There was a hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c64909aa660758747fcc6723cc523db
https://doi.org/10.1038/sj.bjc.6601657

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Epidermal Growth Factor Family and Renal Cell Carcinoma: Expression and Prognostic Impact

Autor: Stefan Riess, Ioannis D. Bassukas, Jobst Dammrich, G. Hofmockel

Publikováno v: European Urology. 31:478-484

OBJECTIVE: Expression and prognostic impact of some exponents of the epidermal growth factor (EGF) family in renal cell carcinoma (RCC) were examined. MATERIALS AND METHODS: EGF, transforming growth factor-alpha (TGF-alpha), EGF receptor (EGF-R), and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b390dff248856eb5cc56c736d7d0a1e3
https://doi.org/10.1159/000474510

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