Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kidney Glomerulus/metabolism"'
Autor:
Viji Nair, Jonathan Allington, Jeffrey M P Holly, Ruth Rollason, Bryony Hayes, Holly Stowell-Connolly, Claire M Perks, Jenny A Hurcombe, Lawrence Gillam, Gavin I. Welsh, Lorna J Hale, Craig A. McArdle, Robert J P Pope, Abigail C Lay, Eva Marquez, Richard J M Coward, Robert G. Nelson, Wenjun Ju, Matthias Kretzler, Timothy Roberts
Publikováno v:
Diabetologia
Lay, A C, Hale, L J, Stowell-Connolly, H, Pope, R J P, Nair, V, Ju, W, Marquez, E, Rollason, R, Hurcombe, J A, Hayes, B, Roberts, T, Gillam, L, Allington, J, Nelson, R G, Kretzler, M, Holly, J M P, Perks, C M, McArdle, C A, Welsh, G I & Coward, R J M 2021, ' IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes ', Diabetologia, vol. 64, no. 7, pp. 1690-1702 . https://doi.org/10.1007/s00125-021-05427-1
Lay, A C, Hale, L J, Stowell-Connolly, H, Pope, R J P, Nair, V, Ju, W, Marquez, E, Rollason, R, Hurcombe, J A, Hayes, B, Roberts, T, Gillam, L, Allington, J, Nelson, R G, Kretzler, M, Holly, J M P, Perks, C M, McArdle, C A, Welsh, G I & Coward, R J M 2021, ' IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes ', Diabetologia, vol. 64, no. 7, pp. 1690-1702 . https://doi.org/10.1007/s00125-021-05427-1
Aims/hypothesis Podocyte loss or injury is one of the earliest features observed in the pathogenesis of diabetic kidney disease (DKD), which is the leading cause of end-stage renal failure worldwide. Dysfunction in the IGF axis, including in IGF bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4761651956872b5d61bf58fab5c3ce4a
Autor:
Pedro Vieira, Flávio Reis, Sofia D. Viana, Sara Nunes, Inês Preguiça, Fernando Mendes, Adelaide Barbosa, André Alves, Diana Raquel Fernandes Martins
Publikováno v:
Nutrients, Vol 12, Iss 4, p 881 (2020)
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Nutrients
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Nutrients
Diabetic nephropathy (DN) is a major microvascular complication of diabetes. Obesity and hyperlipidemia, fueled by unhealthy food habits, are risk factors to glomerular filtration rate (GFR) decline and DN progression. Several studies recommend that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589f17502d2721c822726c59205ab205
https://www.mdpi.com/2072-6643/12/4/881
https://www.mdpi.com/2072-6643/12/4/881
Publikováno v:
Current Heart Failure Reports. 14:331-337
PURPOSE OF REVIEW: This review aims to summarize the renal effects of sodium-glucose transporter-2 (SGLT-2) inhibitors and their potential implications in heart failure pathophysiology. RECENT FINDINGS: In patients with diabetes and established ather
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6fb81eab9a3a804a021f589bce9ac5
https://doi.org/10.1007/s11897-017-0345-9
https://doi.org/10.1007/s11897-017-0345-9
Autor:
Jones, Frances E., Bailey, Matthew A., Murray, Lydia S., Lu, Yinhui, McNeilly, Sarah, Schlötzer-Schrehardt, Ursula, Lennon, Rachel, Sado, Yoshikazu, Brownstein, David G, Mullins, John J, Kadler, Karl E, Van Agtmael, Tom
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 2, Pp 165-176 (2016)
Jones, F E, Bailey, M A, Murray, L S, Lu, Y, McNeilly, S, Schlötzer-Schrehardt, U, Lennon, R, Sado, Y, Brownstein, D G, Mullins, J J, Kadler, K E & Van Agtmael, T 2016, ' ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice. ', DMM Disease Models and Mechanisms, vol. 9, no. 2, pp. 165-76 . https://doi.org/10.1242/dmm.021741, https://doi.org/10.1242/dmm.021741
Jones, F E, Bailey, M A, Murray, L S, Lu, Y, McNeilly, S, Schlötzer-Schrehardt, U, Lennon, R, Sado, Y, Brownstein, D G, Mullins, J J, Kadler, K E & Van Agtmael, T 2016, ' ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice. ', DMM Disease Models and Mechanisms, vol. 9, no. 2, pp. 165-76 . https://doi.org/10.1242/dmm.021741, https://doi.org/10.1242/dmm.021741
Collagen IV is a major component of basement membranes, and mutations in COL4A1, which encodes collagen IV alpha chain 1, cause a multisystemic disease encompassing cerebrovascular, eye and kidney defects. However, COL4A1 renal disease remains poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bd17448c9bc4016f9a4fd196ba851376
http://dmm.biologists.org/content/9/2/165
http://dmm.biologists.org/content/9/2/165
Autor:
Jia Fu, Nicolas Guillot, John Cijiang He, Maja T. Lindenmeyer, Xuezhu Li, Niansong Wang, Kyung Lee, Clemens D. Cohen, Peter Y. Chuang, Wenzhen Xiao, Ying Fan, Raymond C. Harris, Margaret H. Baron, Detlef Schlöndorff
Publikováno v:
Diabetes
Diabetes, American Diabetes Association, 2015, 64 (6), pp.2220-33. ⟨10.2337/db14-1397⟩
Diabetes, American Diabetes Association, 2015, 64 (6), pp.2220-33. ⟨10.2337/db14-1397⟩
International audience; BMP, activin, membrane-bound inhibitor (BAMBI) acts as a pseudo-receptor for the transforming growth factor (TGF)-beta type I receptor family and a negative modulator of TGF-beta kinase signaling, and BAMBI(-/-) mice show mild
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcedf278915b3839c29db19680ebe33
https://hal.archives-ouvertes.fr/hal-01850503
https://hal.archives-ouvertes.fr/hal-01850503
Autor:
Per Svenningsen, René Frydensbjerg Andersen, Kristian B Buhl, Gitte Rye Hinrichs, Claus Bistrup, Flemming Nielsen, Boye L. Jensen, Mette Staehr
Publikováno v:
Staehr, M, Buhl, K B, Andersen, R F, Svenningsen, P, Nielsen, F, Hinrichs, G R, Bistrup, C & Jensen, B L 2015, ' Aberrant glomerular filtration of urokinase-type plasminogen activator in nephrotic syndrome leads to amiloride-sensitive plasminogen activation in urine ', American Journal of Physiology: Renal Physiology, vol. 309, no. 3, pp. F235-41 . https://doi.org/10.1152/ajprenal.00138.2015
Stæhr, M, Buhl, K B, Andersen, R F, Svenningsen, P, Nielsen, F, Hinrichs, G R, Bistrup, C & Jensen, B L 2015, ' Aberrant glomerular filtration of urokinase-type plasminogen activator in nephrotic syndrome leads to amiloride-sensitive plasminogen activation in urine ', American Journal of Physiology: Renal Physiology, vol. 309, no. 3, pp. F235-F241 . https://doi.org/10.1152/ajprenal.00138.2015
Stæhr, M, Buhl, K B, Andersen, R F, Svenningsen, P, Nielsen, F, Hinrichs, G R, Bistrup, C & Jensen, B L 2015, ' Aberrant glomerular filtration of urokinase-type plasminogen activator in nephrotic syndrome leads to amiloride-sensitive plasminogen activation in urine ', American Journal of Physiology: Renal Physiology, vol. 309, no. 3, pp. F235-F241 . https://doi.org/10.1152/ajprenal.00138.2015
In nephrotic syndrome, aberrant glomerular filtration of plasminogen and conversion to active plasmin in preurine are thought to activate proteolytically epithelial sodium channel (ENaC) and contribute to sodium retention and edema. The ENaC blocker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1735cbd9aefee181fc1504624048d15c
https://pubmed.ncbi.nlm.nih.gov/26084931
https://pubmed.ncbi.nlm.nih.gov/26084931
Autor:
Verbrugge, Frederik H, Dupont, Matthias, Steels, Paul, Grieten, Lars, Swennen, Quirine, Tang, W H Wilson, Mullens, Wilfried
This review discusses renal sodium handling in heart failure. Increased sodium avidity and tendency to extracellular volume overload, i.e. congestion, are hallmark features of the heart failure syndrome. Particularly in the case of concomitant renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::eaa2cfde355d356e6bc5a30de069490e
https://doi.org/10.1002/ejhf.35
https://doi.org/10.1002/ejhf.35
Autor:
Amanda J.W. Branten, Jacob Van Den Born, Jan L.J. Jansen, Karel J.M. Assmann, Jack F.M. Wetzels, null with the technical assistance of Henry B.P.M. Dijkman
Publikováno v:
Kidney International, 59(2), 693-701. ELSEVIER SCIENCE INC
Kidney International. Supplement, 59, 2, pp. 693--701
Kidney International. Supplement, 59, 693--701
Kidney International. Supplement, 59, 2, pp. 693--701
Kidney International. Supplement, 59, 693--701
Contains fulltext : 185644.pdf (Publisher’s version ) (Closed access) BACKGROUND: Nephrotic syndrome in childhood is mainly due to minimal change nephropathy. In general, it is characterized by selective proteinuria, by steroid responsiveness, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4edaa63941a5e2dafccd8b4ef0bc85d5
https://hdl.handle.net/2066/185644
https://hdl.handle.net/2066/185644
Publikováno v:
Kidney International. 57(2):385-400
Heparan sulfate (HS) is the anionic polysaccharide side chain of HS proteoglycans (HSPGs) present in basement membranes, in extracellular matrix, and on cell surfaces. Recently, agrin was identified as a major HSPG present in the glomerular basement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___01423::22cea41b0aeed646629cadac05a9b654
https://doi.org/10.1046/j.1523-1755.2000.00858.x
https://doi.org/10.1046/j.1523-1755.2000.00858.x
Publikováno v:
Kidney International. 57(2):385-400
Glomerular heparan sulfate alterations: Mechanisms and relevance for proteinuria. Heparan sulfate (HS) is the anionic polysaccharide side chain of HS proteoglycans (HSPGs) present in basement membranes, in extracellular matrix, and on cell surfaces.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1978f52a7b8abaf401cd16136d72aa
https://doi.org/10.1046/j.1523-1755.2000.00858.x
https://doi.org/10.1046/j.1523-1755.2000.00858.x