Inhaled corticosteroids, blood eosinophils, and FEV1 decline in patients with COPD in a large UK primary health care setting

Autor: Whittaker HR, Müllerova H, Jarvis D, Barnes NC, Jones PW, Compton CH, Kiddle SJ, Quint JK

Publikováno v: International Journal of COPD, Vol Volume 14, Pp 1063-1073 (2019)

Hannah R Whittaker,1 Hana Müllerova,2 Deborah Jarvis,1 Neil C Barnes,2 Paul W Jones,2 Chris H Compton,2 Steven J Kiddle,3 Jennifer K Quint11National Heart and Lung Institute, Imperial College London, London, UK; 2Respiratory Epidemiology, GlaxoSmith

Externí odkaz: https://doaj.org/article/3c1c14ed38fe44d1b4bbe69ba780cb1a

Aptamarker prediction of brain amyloid-β status in cognitively normal individuals at risk for Alzheimer’s disease

Autor: Penner, G, Lecocq, S, Chopin, A, Vedoya, X, Lista, S, Vergallo, A, Cavedo, E, Lejeune, F, Dubois, B, Hampel, H, Bakardjian, H, Benali, H, Bertin, H, Bonheur, J, Boukadida, L, Boukerrou, N, Chiesa, Pa, Colliot, O, Dubois, M, Epelbaum, S, Gagliardi, G, Genthon, R, Habert, M, Houot, M, Kas, A, Lamari, F, Levy, M, Metzinger, C, Mochel, F, Nyasse, F, Poisson, C, Potier, M, Revillon, M, Santos, A, Andrade, Ks, Sole, M, Surtee, M, de Schotten, Mt, Younsi, N, Afshar, M, Aguilar, Lf, Akman-Anderson, L, Aremas, J, Avila, J, Babiloni, C, Baldacci, F, Batrla, R, Benda, N, Black, Kl, Bokde, Alw, Bonuccelli, U, Broich, K, Cacciola, F, Caraci, F, Caruso, G, Castrillo, J, Ceravolo, R, Corbo, M, Corvol, J, Cuello, Ac, Cummings, Jl, Depypere, H, Duggento, A, Emanuele, E, Escott-Price, V, Federoff, H, Ferretti, Mt, Fiandaca, M, Frank, Ra, Garaci, F, Geerts, H, Giacobini, E, Giorgi, Fs, Goetzl, Ej, Graziani, M, Haberkamp, M, Hanisch, B, Herholz, K, Hernandez, F, Imbimbo, Bp, Kapogiannis, D, Karran, E, Kiddle, Sj, Kim, Sh, Koronyo, Y, Koronyo-Hamaoui, M, Langevin, T, Lehericy, S, Lemercier, P, Llavero, F, Lorenceau, J, Lucia, A, Mango, D, Mapstone, M, Neri, C, Nistico, R, O'Bryant, Se, Palermo, G, Perry, G, Ritchie, C, Rossi, S, Saidi, A, Santarnecchi, E, Schneider, Ls, Sporns, O, Toschi, N, Valenzuela, Pl, Vellas, B, Verdooner, Sr, Villain, N, Giudici, Kv, Watling, M, Welikovitch, La, Woodcock, J, Younesi, E, Zugaza, Jl

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2021, 16 (1), pp.e0243902. ⟨10.1371/journal.pone.0243902⟩
PloS one, vol 16, iss 1
PLoS ONE, Vol 16, Iss 1, p e0243902 (2021)

International audience; The traditional approach to biomarker discovery for any pathology has been through hypothesis-based research one candidate at a time. The objective of this study was to develop an agnostic approach for the simultaneous screeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d881581b637d55a202d435939a4af8c
https://hal.sorbonne-universite.fr/hal-03212567/document

Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer’s disease

Autor: Hampel, H, Vergallo, A, Afshar, M, Akman-Anderson, L, Arenas, J, Benda, N, Batrla, R, Broich, K, Caraci, F, Cuello, Ac, Emanuele, E, Haberkamp, M, Kiddle, Sj, Lucia, A, Mapstone, M, Verdooner, Sr, Woodcock, J, Lista, S, Aguilar, Lf, Babiloni, C, Baldacci, F, Black, Kl, Bokde, Alw, Bonuccelli, U, Cacciola, F, Castrillo, J, Cavedo, E, Ceravolo, R, Chiesa, Pa, Corvol, J, Cummings, Jl, Depypere, H, Dubois, B, Duggento, A, Escott-Price, V, Federoff, H, Ferretti, Mt, Fiandaca, M, Frank, Ra, Garaci, F, Geerts, H, Giorgi, Fs, Goetzl, Ej, Graziani, M, Habert, M, Herholz, K, Kapogiannis, D, Karran, E, Kim, Sh, Koronyo, Y, Koronyo-Hamaoui, M, Langevin, T, Lehericy, S, Lorenceau, J, Mango, D, Neri, C, Nistico, R, O'Bryant, Se, Palermo, G, Perry, G, Ritchie, C, Rossi, S, Saidi, A, Santarnecchi, E, Schneider, Ls, Sporns, O, Toschi, N, Villain, N, Welikovitch, La, Younesi, E

Publikováno v: Dialogues in Clinical Neuroscience

Alzheimer's disease (AD)-a complex disease showing multiple pathomechanistic alterations-is triggered by nonlinear dynamic interactions of genetic/epigenetic and environmental risk factors, which, ultimately, converge into a biologically heterogeneou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083d3cd7ad090969a9b06c2c08b1b8b6
http://hdl.handle.net/2108/233412

Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes

Autor: Kiddle, SJ, Steves, CJ, Mehta, M, Simmons, A, Xu, X, Newhouse, S, Sattlecker, M, Ashton, NJ, Bazenet, C, Killick, R, Adnan, J, Westman, E, Nelson, S, Soininen, H, Kloszewska, I, Mecocci, P, Tsolaki, M, Vellas, B, Curtis, C, Breen, G, Williams, SCR, Lovestone, S, Spector, TD, Dobson, RJB

Publikováno v: Kiddle, S J, Steves, C J, Mehta, M, Simmons, A, Xu, X, Newhouse, S, Sattlecker, M, Ashton, N, Bazenet, C, Killick, R, Adnan, J, Westman, E, Nelson, S, Soininen, H, Kloszewska, I, Mecocci, P, Tsolaki, M, Vellas, B, Curtis, C, Breen, G, Williams, S C R, Lovestone, S, Spector, T D & Dobson, R J B 2015, ' Plasma protein biomarkers of Alzheimer’s disease endophenotypes in asymptomatic older twins : early cognitive decline and regional brain volumes ', Translational psychiatry, vol. 5, no. 6, e584 . https://doi.org/10.1038/tp.2015.78
Translational Psychiatry

There is great interest in blood-based markers of Alzheimer's disease (AD), especially in its pre-symptomatic stages. Therefore, we aimed to identify plasma proteins whose levels associate with potential markers of pre-symptomatic AD. We also aimed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1eb1a14f3145fe64434b8b90dfb9790
http://hdl.handle.net/11391/1356681

Urate-lowering therapy in patients with hyperuricemia and heart failure: A retrospective cohort study using the UK Clinical Practice Research Datalink.

Autor: Kiddle SJ; Data Science & Advanced Analytics, Data Science & Artificial Intelligence, R&D, AstraZeneca, Cambridge, UK., Sundell KA; Cardiovascular, Renal and Metabolic (CVRM) Evidence, BioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden., Perl S; Late-stage Development, Clinical, Cardiovascular, Renal and Metabolic (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA., Nolan S; Late-stage Development, Clinical, Cardiovascular, Renal and Metabolic (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Bjursell M; Global Medical Affairs, Clinical, Cardiovascular, Renal and Metabolic (CVRM), BioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden.

Publikováno v: Clinical cardiology [Clin Cardiol] 2024 Jun; Vol. 47 (6), pp. e24297.