Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Kicheon Park"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cocaine is a highly addictive drug, and its use is associated with adverse medical consequences such as cerebrovascular accidents that result in debilitating neurological complications. Indeed, brain imaging studies have reported severe reductions in
Externí odkaz:
https://doaj.org/article/deb1520255bc43a38a5de885f93fd135
Autor:
Yingtian Pan, Kicheon Park, Jiaxiang Ren, Nora D. Volkow, Haibin Ling, Alan P. Koretsky, Congwu Du
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
An imaging platform with self-supervised deep learning allows for the imaging of cerebral blood flows under the effect of cocaine in awake mice using 3D ultrahigh-resolution optical coherence Doppler tomography.
Externí odkaz:
https://doaj.org/article/d08766feac9e4c8f9fa36f6b6ac4bbcf
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Multimodal imaging of the mouse brain following acute cocaine application revealed that cocaine caused a biphasic calcium response in neurons, but not astrocytes, suggesting that these cells play different roles in mediating neurovascular coupling to
Externí odkaz:
https://doaj.org/article/c79b9a8b5b0c4b1382bd269e86309e70
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Cocaine profoundly affects both cerebral blood vessels and neuronal activity in the brain. The vasoconstrictive effects of cocaine, concurrently with its effects on neuronal [Ca2+]i accumulation are likely to jeopardize neuronal tissue that
Externí odkaz:
https://doaj.org/article/ea88d26e68974513839d29049126a933
Autor:
Congwu Du, Yueming Hua, Kevin Clare, Kicheon Park, Craig P. Allen, Nora D. Volkow, Xiu-Ti Hu, Yingtian Pan
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Individuals with substance use disorder are at a higher risk of contracting HIV and progress more rapidly to AIDS as drugs of abuse, such as cocaine, potentiate the neurotoxic effects of HIV-associated proteins including, but not limited to, HIV-1 tr
Externí odkaz:
https://doaj.org/article/5bee7691982b469bbc0d1ec27e5e6c57
Autor:
Kevin Clare, Chelsea Pan, Gloria Kim, Kicheon Park, Juan Zhao, Nora D. Volkow, Zhicheng Lin, Congwu Du
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Addiction to cocaine is associated with dysfunction of the dopamine mesocortical system including impaired dopamine-2 receptor (D2r) signaling. However, the effects of chronic cocaine on neuronal adaptations in this system have not been systematicall
Externí odkaz:
https://doaj.org/article/a56f364854dd49fa93502361da7ed25d
Publikováno v:
NeuroImage, Vol 210, Iss , Pp 116554- (2020)
Spontaneous brain activity has been widely used to map brain connectivity. The interactions between task-evoked brain responses and the spontaneous cortical oscillations, especially within the low frequency range of ~0.1 Hz, are not fully understo
Externí odkaz:
https://doaj.org/article/84915a0f786440eeb5a531576149395c
Publikováno v:
Frontiers in Pharmacology; 2024, p01-17, 17p
Cocaine affects both cerebral blood vessels and neuronal activity in brain. Cocaine can also disrupt astrocytes, which are involved in neurovascular coupling process that modulates cerebral hemodynamics in response to neuronal activity. However, sepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c831a672ef056e465d109c8073b92735
https://doi.org/10.21203/rs.3.rs-2626090/v1
https://doi.org/10.21203/rs.3.rs-2626090/v1
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry
Translational Psychiatry
Cocaine profoundly affects both cerebral blood vessels and neuronal activity in the brain. The vasoconstrictive effects of cocaine, concurrently with its effects on neuronal [Ca2+]i accumulation are likely to jeopardize neuronal tissue that in the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f38bf394a085711e323c2e1225f88a
https://doaj.org/article/ea88d26e68974513839d29049126a933
https://doaj.org/article/ea88d26e68974513839d29049126a933