Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kibrom M, Alula"'
Autor:
Kibrom M. Alula, Alexander S. Dowdell, Brittany LeBere, J. Scott Lee, Cassandra L. Levens, Kristine A. Kuhn, Benny A. Kaipparettu, Winston E. Thompson, Richard S. Blumberg, Sean P. Colgan, Arianne L. Theiss
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-18 (2023)
Abstract Background Intestinal epithelial cell (IEC) mitochondrial dysfunction involvement in inflammatory bowel diseases (IBD), including Crohn’s disease affecting the small intestine, is emerging in recent studies. As the interface between the se
Externí odkaz:
https://doaj.org/article/36c5ad394b184355bc205693bbd88452
Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy
Autor:
Kibrom M. Alula, Yaritza Delgado-Deida, Rosemary Callahan, Andreas Till, Lucia Underwood, Winston E. Thompson, Rhonda F. Souza, Themistocles Dassopoulos, Joseph Onyiah, K. Venuprasad, Arianne L. Theiss
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Autophagy of damaged mitochondria, called mitophagy, is an important organelle quality control process involved in the pathogenesis of inflammation, cancer, aging, and age-associated diseases. Many of these disorders are associated with alte
Externí odkaz:
https://doaj.org/article/409c2db6f86d4000bd758ce74a53ab92
Autor:
Kibrom M. Alula, Arianne L. Theiss
Publikováno v:
Cells, Vol 12, Iss 13, p 1779 (2023)
Crohn’s disease (CD) is a chronic inflammatory bowel disease marked by relapsing, transmural intestinal inflammation driven by innate and adaptive immune responses. Autophagy is a multi-step process that plays a critical role in maintaining cellula
Externí odkaz:
https://doaj.org/article/771b8b8727dc4c58af64b6d7599ef5f1
Autor:
Kibrom M. Alula, Dakota N. Jackson, Andrew D. Smith, Daniel S. Kim, Kevin Turner, Elizabeth Odstrcil, Benny A. Kaipparettu, Themistocles Dassopoulos, K. Venuprasad, Linda A. Feagins, Arianne L. Theiss
Publikováno v:
Cells, Vol 10, Iss 6, p 1349 (2021)
Paneth cell defects in Crohn’s disease (CD) patients (called the Type I phenotype) are associated with worse clinical outcomes. Recent studies have implicated mitochondrial dysfunction in Paneth cells as a mediator of ileitis in mice. We hypothesiz
Externí odkaz:
https://doaj.org/article/9a244ebc2520425894a647d83e021d73
Autor:
Arianne L. Theiss, Laurent Désaubry, Rhonda F. Souza, K. Venuprasad, Xuan Wang, Kevin Turner, Redouane Tabti, Yaritza Delgado-Deida, Kibrom M. Alula, Dakota N. Jackson
Colorectal cancer exhibits aberrant activation of Wnt/β-catenin signaling. Many inhibitors of the Wnt/β-catenin pathway have been tested for Wnt-dependent cancers including colorectal cancer, but are unsuccessful due to severe adverse reactions. FL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55906f2feca0c3031efb7c66596c8cb8
https://doi.org/10.1158/0008-5472.c.6512415
https://doi.org/10.1158/0008-5472.c.6512415
Autor:
Arianne L. Theiss, Laurent Désaubry, Rhonda F. Souza, K. Venuprasad, Xuan Wang, Kevin Turner, Redouane Tabti, Yaritza Delgado-Deida, Kibrom M. Alula, Dakota N. Jackson
FL3 does not decrease viability in IEC6 cells compared to standard CRC chemotherapeutic drugs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045a5323bfa94977f4fe0a459c1a85ca
https://doi.org/10.1158/0008-5472.22426635.v1
https://doi.org/10.1158/0008-5472.22426635.v1
Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy
Autor:
Kibrom M, Alula, Yaritza, Delgado-Deida, Rosemary, Callahan, Andreas, Till, Lucia, Underwood, Winston E, Thompson, Rhonda F, Souza, Themistocles, Dassopoulos, Joseph, Onyiah, K, Venuprasad, Arianne L, Theiss
Publikováno v:
Scientific reports. 13(1)
Autophagy of damaged mitochondria, called mitophagy, is an important organelle quality control process involved in the pathogenesis of inflammation, cancer, aging, and age-associated diseases. Many of these disorders are associated with altered expre
Publikováno v:
Oncogene
The Wnt/β-catenin signaling pathway is aberrantly activated in the majority of colorectal cancer cases due to somatic mutations in the adenomatous polyposis coli (APC) gene. Prohibitin 1 (PHB1) serves pleiotropic cellular functions with dynamic subc
Publikováno v:
Gastroenterology Report
Mitochondria are dynamic organelles that play a key role in integrating cellular signaling. Mitochondrial alterations are evident in all stages of tumorigenesis and targeting mitochondrial pathways has emerged as an anticancer therapeutic strategy. T
Publikováno v:
Gravitational and Space Research. 7:13-21
Alteration in gravitational load impacts homeorhetic response in rat dams which affects neonatal pup survival. However, the effects of hypergravity (HG) exposure on the abundance of apoptosis-associated proteins in mammary epithelial cells (MECs) hav